Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert J. Resvick"'
Autor:
Robert J. Resvick, Dirk Friedrich, Norton P. Peet, Burkhart Joseph P, Roy J. Vaz, Philippe Bey, Cynthia A. Gates, Philip M. Weintraub, Angelastro Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:929-934
20-Fluoro-17(20)-pregnenolone derivatives were designed as enol mimics of pregnenolone. All of the targeted, novel fluoroolefins were potent inhibitors of C 17(20) lyase.
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1411-1420
Steroids bearing a heteroaromatic substituent at C-17 were designed as inhibitors of C 17(20) lyase. The thiazoles, furans, and thiophenes appended to the steroid nucleus were positioned on the α-face and the β-face of the steroid, and conjugated w
Autor:
Dirk Friederich, Norton P. Peet, Michael R. Angelastro, Roy J. Vaz, Robert J. Resvick, Joseph P. Burkhart, Cynthia A. Gates, Philip M. Weintraub, Philippe Bey
Publikováno v:
ChemInform. 33
Autor:
Philippe Bey, Norton P. Peet, Philip M. Weintraub, Amy K. Holland, Cynthia A. Gates, William R. Moore, Robert J. Resvick
Publikováno v:
Bioorganicmedicinal chemistry. 11(3)
Novel 21,21-difluorovinyl steroids, designed as difluorinated C20(21) enol mimics of pregnenolone, were targeted as potential mechanism-based inhibitors of C17(20) lyase, a crucial enzyme in the biosynthesis of testosterone. Addition of (difluorometh
Autor:
Bruce J. Lippert, Salituro Francesco G, Ian A. McDonald, Herschel J. R. Weintraub, Robert J. Resvick, David A. Demeter
Publikováno v:
Journal of Medicinal Chemistry. 37:4076-4078
Autor:
James R. McCarthy, Prasad S. Sunkara, Donald P. Matthews, Alan J. Bitonti, Esa T. Jarvi, Jeffrey S. Sabol, Robert J. Resvick, Edward W. Huber, Wilfred A. van der Donk, Guixue Yu, JoAnne Stubbe
Publikováno v:
ACS Symposium Series ISBN: 9780841234420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e0a68515bbc26ca5c42d71bdc3a408
https://doi.org/10.1021/bk-1996-0639.ch018
https://doi.org/10.1021/bk-1996-0639.ch018
Publikováno v:
Biochemical and Biophysical Research Communications. 108:146-152
γ-Aminobutyric acid-α-ketoglutarate aminotransferase from rat and mouse brain was irreversibly inhibited by 5-fluoro-4-oxo-pentanoic acid, an analogue of succinic semi-aldehyde. The inhibition was concentration and temperature-dependent, and was in