Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Robert J. Parmer"'
Autor:
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas deLaat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 113-135 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminogen to PDAC d
Externí odkaz:
https://doaj.org/article/d7e6f70905c245e1a019d7d8c2f2e56f
Autor:
Akshay Bareja, David E. Lee, Tricia Ho, Greg Waitt, Lauren H. McKay, Sarah A. Hannou, Melissa C. Orenduff, Kristen M. McGreevy, Alexandra Binder, Calen P. Ryan, Erik J. Soderblom, Daniel W. Belsky, Luigi Ferrucci, Jayanta Kumar Das, Nirad Banskota, Virginia B. Kraus, Janet L. Huebner, William E. Kraus, Kim M. Huffman, Gurpreet S. Baht, Steve Horvath, Robert J. Parmer, Lindsey A. Miles, James P. White
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113881- (2024)
Summary: An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilize
Externí odkaz:
https://doaj.org/article/427aacba1e9c45278727a51ef1f744a6
Autor:
Lindsey A. Miles, Hongdong Bai, Sagarika Chakrabarty, Nagyung Baik, Yuqing Zhang, Robert J. Parmer, Fahumiya Samad
Publikováno v:
Adipocyte, Vol 12, Iss 1 (2023)
ABSTRACTThe plasminogen receptor, Plg-RKT, is a unique cell surface receptor that is broadly expressed in cells and tissues throughout the body. Plg-RKT localizes plasminogen on cell surfaces and promotes its activation to the broad-spectrum serine p
Externí odkaz:
https://doaj.org/article/07f18effa3a140c2a8a4d63cb148d7f0
Autor:
Juliana P. Vago, Isabella Zaidan, Luiza O. Perucci, Larissa Froede Brito, Lívia C.R. Teixeira, Camila Meirelles Souza Silva, Thaís C. Miranda, Eliza M. Melo, Alexandre S. Bruno, Celso Martins Queiroz-Junior, Michelle A. Sugimoto, Luciana P. Tavares, Laís C. Grossi, Isabela N. Borges, Ayda Henriques Schneider, Nagyung Baik, Ayda H. Schneider, André Talvani, Raphael G. Ferreira, José C. Alves-Filho, Vandack Nobre, Mauro M. Teixeira, Robert J. Parmer, Lindsey A. Miles, Lirlândia P. Sousa
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Sepsis is a lethal syndrome characterized by systemic inflammation and abnormal coagulation. Despite therapeutic advances, sepsis mortality remains substantially high. Herein, we investigated the role of the plasminogen/plasmin (Plg/Pla) system durin
Externí odkaz:
https://doaj.org/article/a65d5415319d433fa20d04546ae5d303
Autor:
Lina Ny, Robert J. Parmer, Yue Shen, Sandra Holmberg, Nagyung Baik, Assar Bäckman, Jessica Broden, Malgorzata Wilczynska, Tor Ny, Lindsey A. Miles
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-15 (2020)
Abstract Wound healing is a complex physiologic process that proceeds in overlapping, sequential steps. Plasminogen promotes fibrinolysis and potentiates the inflammatory response during wound healing. We have tested the hypothesis that the novel pla
Externí odkaz:
https://doaj.org/article/1c46c49f28ce42a688b1373f2896d9f3
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 503 (2022)
The plasminogen activation system regulates the activity of the serine protease, plasmin. The role of plasminogen receptors in cancer progression is being increasingly appreciated as key players in modulation of the tumor microenvironment. The intera
Externí odkaz:
https://doaj.org/article/4a1eed713ca347da8f2af168bbe2a656
Autor:
Juliana P. Vago, Michelle A. Sugimoto, Kátia M. Lima, Graziele L. Negreiros-Lima, Nagyung Baik, Mauro M. Teixeira, Mauro Perretti, Robert J. Parmer, Lindsey A. Miles, Lirlândia P. Sousa
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammation resolution is an active process that functions to restore tissue homeostasis. Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important role in inflammation resolution and induces remarkable macrophage p
Externí odkaz:
https://doaj.org/article/467e28c9c5f74cbab313a6308e481f5c
Publikováno v:
Biomolecules. 12(4)
The plasminogen activation system regulates the activity of the serine protease, plasmin. The role of plasminogen receptors in cancer progression is being increasingly appreciated as key players in modulation of the tumor microenvironment. The intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f725cc93382404bece3385c7a90dd84b
https://pubmed.ncbi.nlm.nih.gov/35454092
https://pubmed.ncbi.nlm.nih.gov/35454092
Autor:
Fahumiya Samad, Hongdong Bai, Nagyung Baik, Patrick Haider, Yuqing Zhang, Gersina Rega‐Kaun, Christoph Kaun, Manfred Prager, Johann Wojta, Quyen Bui, Sagarika Chakrabarty, Jing Wang, Robert J. Parmer, Lindsey A. Miles
Publikováno v:
J Thromb Haemost
BACKGROUND: Plg-R(KT), a unique transmembrane plasminogen receptor, enhances the activation of plasminogen to plasmin, and localizes the proteolytic activity of plasmin on the cell surface. OBJECTIVES: We investigated the role of Plg-R(KT) in adipose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf91f6053bc60722eadd65bac959b5d
https://europepmc.org/articles/PMC8885904/
https://europepmc.org/articles/PMC8885904/
Autor:
Luiza O. Perucci, Josiane C. Souza, Lais C. Grossi, Jessica A.M. Souza, Isabella Zaidan, Luciana P. Tavares, Mauro M. Teixeira, Robert J. Parmer, Lindsey A. Miles, Lirlandia P. Sousa
Publikováno v:
Blood. 140:8425-8425
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f8defd074b84862cf14690b31fab3cd
https://doi.org/10.1182/blood-2022-162876
https://doi.org/10.1182/blood-2022-162876