Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert J. Natuk"'
Autor:
R. Michael Hendry, Jennifer Obregon, Narender K. Kalyan, J. Erik Johnson, Kevin J. Wright, Robert J. Natuk, David A. Cooper, David K. Clarke, Priscilla Calderon, Stephen A. Udem, John W. Coleman, Eleanor Ogin-Wilson
Publikováno v:
Vaccine
Recombinant vesicular stomatitis viruses (rVSVs) are being developed as potential HIV-1 vaccine candidates. To characterize the in vivo replication and dissemination of rVSV vectors in mice, high doses of a highly attenuated vector expressing HIV-1 G
Autor:
David K. Clarke, Irene Yurgelonis, J. Erik Johnson, Cheryl S. Kotash, David K. C. Cooper, Farooq Nasar, Min Guo, Margaret Lee, Priscilla Calderon, Robert J. Natuk, R. Michael Hendry, John W. Coleman, Stephen A. Udem, Kevin J. Wright
Publikováno v:
Journal of Virology
Recombinant vesicular stomatitis virus (rVSV) has shown great potential as a new viral vector for vaccination. However, the prototypic rVSV vector described previously was found to be insufficiently attenuated for clinical evaluation when assessed fo
Autor:
Tom P. Brown, Christopher L. Parks, Stephen A. Udem, Deborah Long, Jian Ren, Heather Arendt, Jacek Kowalski, Donna Tummolo, Robert J. Natuk, Karissa Adkins, Joanne DeStefano, Jennifer Obregon, Seema S Gangolli
Publikováno v:
Vaccine. 25:2296-2305
The safety of a propagation-defective Venezuelan equine encephalitis virus (VEEV) replicon particle vaccine was examined in mice. After intracranial inoculation we observed approximately 5% body weight loss, modest inflammatory changes in the brain,
Autor:
Stephen A. Udem, Min Guo, J. Erik Johnson, Kevin J. Wright, David K. Clarke, Priscilla Calderon, Farooq Nasar, Margaret Lee, David K. C. Cooper, R. Michael Hendry, Robert J. Natuk
Publikováno v:
Journal of Virology. 81:2056-2064
A variety of rational approaches to attenuate growth and virulence of vesicular stomatitis virus (VSV) have been described previously. These include gene shuffling, truncation of the cytoplasmic tail of the G protein, and generation of noncytopathic
Autor:
Robert J. Visalli, Min Guo, Deborah Long, Jacek Kowalski, Donna Tummolo, Robert J. Natuk, David K. C. Cooper, Susan J. Blakeney, Timothy J. Zamb, Seema S Gangolli, Joanne DeStefano
Publikováno v:
Journal of Virology. 79:10498-10506
A herpes simplex virus type 2 (HSV-2) UL24 β-glucuronidase (UL24-βgluc) insertion mutant was derived from HSV-2 strain 186 via standard marker transfer techniques. Cell monolayers infected with UL24-βgluc yielded cytopathic effect with syncytium f
Autor:
Robert J. Natuk, Beate Schmoele-Thoma, Daniel A. Scott, William C. Gruber, Jacob Lalezari, Alejandra Gurtman, Wendy Watson, Cynthia Brinson, Richard N. Greenberg, Daniel J. Skiest, Vani Sundaraiyer, Emilio A. Emini, Marshall J. Glesby
Publikováno v:
The Journal of infectious diseases. 212(1)
Background Persons with human immunodeficiency virus (HIV) infection are at increased risk of pneumococcal disease. We evaluated the safety and immunogenicity of 13-valent pneumococcal conjugate vaccine (PCV13) in this population. Methods HIV-infecte
Autor:
Phillip D. Markham, Pranab K. Chanda, Robert J. Natuk, Maria Myagkikh, Mark R. Wade, Narender K. Kalyan, Alan R. Davis, Susan Zolla-Pazner, Shabnam Alipanah, Shri C.S. Murthy, Larry O. Arthur, Robert C. Gallo, Kathy Steimer, Marjorie Robert-Guroff, Satoshi Mizutani, Marvin S. Reitz, Faruk Sinangil, Stephen M. Nigida, Michael D. Lubeck, Jorg Eichberg, Kristine Aldrich, Paul P. Hung
Publikováno v:
Nature Medicine. 3:651-658
A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved agai
Autor:
David A. Cooper, Susan J. Blakeney, Robert J. Natuk, Min Guo, Robert J. Visalli, Jacek Kowalski, Seema S Gangolli
Publikováno v:
Vaccine. 32(12)
The rational design and development of genetically attenuated HSV-2 mutant viruses represent an attractive approach for developing both prophylactic and therapeutic vaccines for genital herpes. Previously, HSV-2 UL24 was shown to be a virulence deter
Autor:
Mark S. Wade, Bheem M. Bhat, Surendra K. Dheer, Pranab K. Chanda, Ramesh A. Bhat, Michael D. Lubeck, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Paul P. Hung, Krishna K. Murthy, Murty Chengalvala, Alan R. Davis, Robert J. Natuk, Satoshi Mizutani
Publikováno v:
AIDS Research and Human Retroviruses. 10:1443-1449
Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in chimpanzees following intranasal administration. When Ad7-, Ad4-, and Ad5-vectored vaccines were admi
Autor:
Robert J. Natuk, Satoshi Mizutani, Bruce B. Mason, Paul P. Hung, Michael D. Lubeck, Alan R. Davis, Bernard J. Selling, Murty Chengalvala, Ramesh A. Bhat, Pranab K. Chanda, Bheem M. Bhat, Kuo-Hom Lee Hsu
Publikováno v:
Current Opinion in Biotechnology. 2:718-722
Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreig