Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert J. Nadeau"'
Autor:
Martin O. Evans, Darren M. Smith, Adrian T. Kress, Robert J. Nadeau, Daniel J. Selig, Diana Caridha, Ratanachat Racharaks, Thomas Langowski, Michael S. Madejczyk, Chance Carbaugh, David Saunders, Mark Widder, Jason De Meese, Patricia J. Lee, Jesse P. DeLuca
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Plerixafor is a CXCR4 antagonist approved in 2008 by the FDA for hematopoietic stem cell collection. Subsequently, plerixafor has shown promise as a potential pathogen‐agnostic immunomodulator in a variety of preclinical animal models. Add
Externí odkaz:
https://doaj.org/article/e1f253fa61f04f4a85dd315fe4e40e06
Autor:
David A. Kerling, Sarah C. Clarke, Jesse P. DeLuca, Martin O. Evans, Adrian T. Kress, Robert J. Nadeau, Daniel J. Selig
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1411 (2023)
Loop diuretics and antibiotics are commonly co-prescribed across many clinical care settings. Loop diuretics may alter antibiotic pharmacokinetics (PK) via several potential drug interactions. A systematic review of the literature was performed to in
Externí odkaz:
https://doaj.org/article/c6f3b54ef83f476eb99186ef843b6c09
Publikováno v:
Antibiotics, Vol 12, Iss 3, p 444 (2023)
Introduction: Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and clinical factors that may affect PTA for beta-lactams. Methods: We performed a mini
Externí odkaz:
https://doaj.org/article/fe82a16df2734ad1856b1855cccc3952
Autor:
Daniel J. Selig, Jesse P. DeLuca, Kevin K. Chung, Kaitlin A. Pruskowski, Jeffrey R. Livezey, Robert J. Nadeau, Elaine D. Por, Kevin S. Akers
Publikováno v:
Journal of clinical pharmacy and therapeutics. 47(8)
Timely and appropriate dosing of antibiotics is essential for the treatment of bacterial sepsis. Critically ill patients treated with continuous kidney replacement therapy (CKRT) often have physiologic derangements that affect pharmacokinetics (PK) o
Autor:
Robert J. Nadeau, Md. Ruhul Abid, Shou-Ching Shih, Dan Li, William C. Aird, Takashi Minami, Katherine Spokes
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:2042-2048
Objective— Recently, we reported that the forkhead transcription factor, FKHR/FOXO1, is required for vascular endothelial growth factor (VEGF)–mediated upregulation of a number of genes in endothelial cells. Here, we tested the hypothesis that he
Autor:
Christina Cinelli, Jessica L. Toher, Alexis Lincoln, Robert J. Nadeau, Ruth G. Leon, Carla Mouta-Bellum, Robert Friesel, Christine F. O'Neill, Lucy Liaw, Sumithra Urs
Publikováno v:
The American Journal of Pathology. 171:1023-1036
Notch functions as an oncogene or tumor inhibitor in various cancers, and decreases in Notch2 expression are associated with increasing grade of human breast cancer. We constitutively activated Notch signaling with intracellular domain (ICD) expressi
Autor:
Lauren K. Harkins, Olga Zubanova, Dmitry Kovalenko, Lucy Liaw, Robert Friesel, Pei-Yu Chen, Volkhard Lindner, Jessica L. Toher, Anne Harrington, Robert J. Nadeau, Xuehui Yang
Publikováno v:
Developmental biology. 321(1)
The FGF signaling pathway plays essential roles in endochondral ossification by regulating osteoblast proliferation and differentiation, chondrocyte proliferation, hypertrophy, and apoptosis. FGF signaling is controlled by the complementary action of
Publikováno v:
Journal of cellular biochemistry. 100(1)
Mammalian Sprouty (Spry) gene expression is rapidly induced upon activation of the FGF receptor signaling pathway in multiple cell types including cells of mesenchymal and epithelial origin. Spry2 inhibits FGF-dependent ERK activation and thus Spry a
Autor:
Robert J. Nadeau, Dmitry Kovalenko, Pei-Yu Chen, Robert Friesel, Kathleen Pigeon, Olga Zubanova, Xuehui Yang
Publikováno v:
Cellular signalling. 18(11)
Sef ( s imilar e xpression to f gf genes) is a member of the fibroblast growth factor (FGF) synexpression group that negatively regulates FGF receptor (FGFR) signaling in zebrafish during early embryonic development and in mammalian cell culture syst
Autor:
Xuehui Yang, Dmitry Kovalenko, Robert J. Nadeau, Robert Friesel, Pei-Yu Chen, Olga Zubanova, J. B. Webster
Publikováno v:
Calcified tissue international. 78(4)
Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) are major regulators of skeletal growth and development. Signal transduction via FGFRs is complex and mediates proliferation, differentiation, or migration depending upon