Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Robert J. Lechleider"'
Autor:
Haifeng Bao, Patricia A Burke, Jiaqi Huang, Xiaoru Chen, Philip Z Brohawn, Yihong Yao, Robert J Lechleider, Robert S Sikorski, Manuela Buzoianu, Jianliang Zhang, Xiaoqing Shi, Laura K Richman, Theresa M Lavallee
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e58557 (2013)
Clinical development of cancer drugs has a low success rate. Prognostic and predictive biomarkers using minimally invasive approaches hold promise for increasing the probability of success by enabling disease characterization, patient selection and e
Externí odkaz:
https://doaj.org/article/ff0ac372f7cf471a972fe55d559059d6
Autor:
Regina M. Day, Young H. Lee, Thomas Rajan, Usamah S. Kayyali, Robert J. Lechleider, Anne Marie Sousa
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 37:485-493
Transforming growth factor (TGF)-beta1 activity has been shown to increase vascular endothelial barrier permeability, which is believed to precede several pathologic conditions, including pulmonary edema and vessel inflammation. In endothelial monola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d73de5543ca295f52149c3f441590b
https://doi.org/10.1165/rcmb.2006-0439oc
https://doi.org/10.1165/rcmb.2006-0439oc
Publikováno v:
Biochemical and Biophysical Research Communications. 345:595-601
Transforming growth factor-beta (TGF-beta) is the prototypical member of a family of growth factors that play important roles in normal development and human diseases. We identified the gene for fibroblast growth factor-binding protein 1 (FGF-BP1) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cab7f9a1103f396fb9d048067428988
https://doi.org/10.1016/j.bbrc.2006.04.052
https://doi.org/10.1016/j.bbrc.2006.04.052
Autor:
Jennifer E. Leader, Victorino R. Briones, Pedro A. Jose, Michelle Crawford, Robert J. Lechleider, Regina M. Day, Shiyou Chen
Publikováno v:
Journal of Biological Chemistry. 281:1765-1770
We recently reported that transforming growth factor (TGF)-beta induced the neural crest stem cell line Monc-1 to differentiate into a spindle-like contractile smooth muscle cell (SMC) phenotype and that Smad signaling played an important role in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d91f5a10314d41637f39d4359ac91a
https://doi.org/10.1074/jbc.m507771200
https://doi.org/10.1074/jbc.m507771200
Autor:
Shiyou Chen, Robert J. Lechleider
Publikováno v:
Circulation Research. 94:1195-1202
During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in larger vessels. The cellular lineage of smooth muscle precursors and factors responsible for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3c7508024b4d1979b9e5d20e484413
https://doi.org/10.1161/01.res.0000126897.41658.81
https://doi.org/10.1161/01.res.0000126897.41658.81
Autor:
Michelle Crawford, Naomi Yoo, Pilar Frontelo, Alex C Potocki, Jennifer E. Leader, Magdalena Kulik, Robert J. Lechleider
Publikováno v:
Oncogene. 23:5242-5251
Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands to regulate the expression of target genes. In order to identify novel partners of Smad proteins in transcriptional regulation, we performed a two-hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d669671f7558b13ba0d87dbeffaaf44e
https://doi.org/10.1038/sj.onc.1207660
https://doi.org/10.1038/sj.onc.1207660
Autor:
Mark C. Fishman, Robert J. Lechleider, Van N. Pham, Sarah J. Childs, Deborah M. Garrity, Randall T. Moon, Magdalena Kulik, Beth L. Roman, Nathan D. Lawson, Arne C. Lekven, Brant M. Weinstein
Publikováno v:
Development. 129:3009-3019
The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilated cranial vessels and fail to perfuse the trunk and tai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a3774df025df0d9476f999172a1829
https://doi.org/10.1242/dev.129.12.3009
https://doi.org/10.1242/dev.129.12.3009
Autor:
Robert J. Lechleider, Lisa Garrett, Chu-Xia Deng, Julie L. Ryan, Anita B. Roberts, China Eng, Anthony Wynshaw-Boris
Publikováno v:
Developmental Biology. 240(1):157-167
The Smad family of intracellular signaling intermediates transduce signals downstream from the transforming growth factor beta (TGF-β) family of receptor serine threonine kinases. The original member of this family, Smad1, has been shown to mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398f2739f8abc702cf6910fa2f8f9859
Autor:
Franck Verrecchia, Robert J. Lechleider, Jouni Uitto, Alain Mauviel, Laurence Vindevoghel, Anita B. Roberts
Publikováno v:
Oncogene. 20:3332-3340
Smad proteins transduce signals from TGF-beta receptors and regulate transcription of target genes either directly or in combination with other sequence-specific transcription factors. AP-1 sites and their cognate transcription factors also play impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ec6d2f99ab88094f1b03ef44f34314
https://doi.org/10.1038/sj.onc.1204448
https://doi.org/10.1038/sj.onc.1204448
Autor:
Carla Huff, Robert J. Lechleider, James G. McNally, Anita B. Roberts, Xianwang Meng, W. Tony Parks, Simeon I. Taylor, Carol Renfrew Haft, Amit R. Reddi, T C Wang, Mark P. de Caestecker, Jennifer Martin, David B. Frank
Publikováno v:
Journal of Biological Chemistry. 276:19332-19339
Sorting nexins (SNX) comprise a family of proteins with homology to several yeast proteins, including Vps5p and Mvp1p, that are required for the sorting of proteins to the yeast vacuole. Human SNX1, -2, and -4 have been proposed to play a role in rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03952572f22b2787734197c712c502e2
https://doi.org/10.1074/jbc.m100606200
https://doi.org/10.1074/jbc.m100606200