Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert J. Ihry"'
Autor:
Robert J. Ihry, Max R. Salick, Daniel J. Ho, Marie Sondey, Sravya Kommineni, Steven Paula, Joe Raymond, Beata Henry, Elizabeth Frias, Qiong Wang, Kathleen A. Worringer, Chaoyang Ye, Carsten Russ, John S. Reece-Hoyes, Robert C. Altshuler, Ranjit Randhawa, Zinger Yang, Gregory McAllister, Gregory R. Hoffman, Ricardo Dolmetsch, Ajamete Kaykas
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 616-630.e6 (2019)
Summary: Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited by techni
Externí odkaz:
https://doaj.org/article/39ad2f3ea8e94904a721c8785edecb36
Autor:
Jingyao Li, Daniel J. Ho, Martin Henault, Chian Yang, Marilisa Neri, Robin Ge, Steffen Renner, Leandra Mansur, Alicia Lindeman, Brian Kelly, Tayfun Tumkaya, Xiaoling Ke, Gilberto Soler-Llavina, Gopi Shanker, Carsten Russ, Marc Hild, Caroline Gubser Keller, Jeremy L. Jenkins, Kathleen A. Worringer, Frederic D. Sigoillot, Robert J. Ihry
Publikováno v:
ACS chemical biology. 17(6)
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84df92c55bb23f5e3de70243ffd28703
https://pubmed.ncbi.nlm.nih.gov/35508359
https://pubmed.ncbi.nlm.nih.gov/35508359
Autor:
S. H. Cheon, J. Chung, Tayfun Tumkaya, Joe Raymond, Ricardo E. Dolmetsch, Katie A. Worringer, Y. Sun, B. Henry, J. Dvornik, J. Khlghatyan, Robert J. Ihry, M. Kostic, J. Hsiao
SUMMARYCopy number variants (CNVs) that delete or duplicate 30 genes within the 16p11.2 genomic region give rise to a range of neurodevelopmental phenotypes with high penetrance in humans. Despite the identification of this small region, the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::653141757fd03785ec9c163905ad5486
https://doi.org/10.1101/2021.11.21.469432
https://doi.org/10.1101/2021.11.21.469432
Autor:
Kathleen A. Worringer, Robert J. Ihry, Marc Hild, Carsten Russ, Marilisa Neri, Leandra Mansur, Alicia Lindeman, Frederic Sigoillot, Chian Yang, Robin Ge, Jeremy L. Jenkins, Daniel J. Ho, Caroline Gubser Keller, Tayfun Tumkaya, Jingyao Li, Steffen Renner, Martin Henault
Unbiased transcriptomic RNA-seq data has provided deep insights about biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d7c984cbca815756ba3415d0008b95
https://doi.org/10.1101/2021.06.07.447456
https://doi.org/10.1101/2021.06.07.447456
Autor:
Robert J. Ihry, Nadezda Mostacci, Gregory McAllister, Martin Henault, Caroline Gubser Keller, Jeremy L. Jenkins, Steffen Renner, Daniel J. Ho, Chaoyang Ye, Ajamete Kaykas, Marilisa Neri, Chian Yang, Leandra Mansur, Marc Hild, Tripti Kulkarni, Pierre Farmer, Ranjit Randhawa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications
Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening, yet current platforms have limited readouts. RNA-seq is a powerful tool to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9089b74819c1f0e0dfaf422f38c70de
https://doi.org/10.1038/s41467-018-06500-x
https://doi.org/10.1038/s41467-018-06500-x
Autor:
Gregory R. Hoffman, Kathleen A. Worringer, Ranjit Randhawa, Sravya Kommineni, Robert J. Ihry, Gregory McAllister, Marie Sondey, Steven Paula, Ricardo E. Dolmetsch, Zinger Yang, Ajamete Kaykas, Elizabeth Frias, Daniel J. Ho, Joe Raymond, Bob Altshuler, Max R. Salick, Carsten Russ, John S. Reece-Hoyes
Publikováno v:
SSRN Electronic Journal.
Human pluripotent stem cells (hPSCs) generate a wide variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited because of te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c345a1bdb5c383f6a79f625d6ac07ed
https://doi.org/10.2139/ssrn.3189387
https://doi.org/10.2139/ssrn.3189387
Autor:
Elizabeth Frias, Carsten Russ, Sravya Kommineni, Robert J. Ihry, William C. Forrester, Marie Sondey, Kraig M. Theriault, Chaoyang Ye, Ajamete Kaykas, Daniel J. Ho, Ricardo E. Dolmetsch, Kathleen A. Worringer, Max R. Salick, Gregory R. Hoffman, Gregory McAllister, Tripti Kulkarni, Julie Chen, Zinger Yang, Ranjit Randhawa, John S. Reece-Hoyes
Publikováno v:
Nature medicine. 24(7)
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1–3. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cells (hPSCs) have been difficult to eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f9a2862fe1c264657cc670822d146f
https://pubmed.ncbi.nlm.nih.gov/30017531
https://pubmed.ncbi.nlm.nih.gov/30017531
Autor:
Elizabeth Frias, Sravya Kommineni, Robert J. Ihry, William C. Forrester, Gregory R. Hoffman, Zinger Yang, Julie Chen, John S. Reece-Hoyes, Kraig M. Theriault, Ricardo E. Dolmetsch, Kathleen A. Worringer, Ranjit Randhawa, Gregory McAllister, Chaoyang Ye, Ajamete Kaykas, Marie Sondey, Daniel J. Ho, Carsten Russ, Max R. Salick, Tripti Kulkarni
SUMMARYCRISPR/Cas9 has revolutionized our ability to engineer genomes and to conduct genome-wide screens in human cells. While some cell types are easily modified with Cas9, human pluripotent stem cells (hPSCs) poorly tolerate Cas9 and are difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797ae6d4b1233a54537a871283080643
https://doi.org/10.1101/168443
https://doi.org/10.1101/168443
Autor:
Arash Bashirullah, Robert J. Ihry
Publikováno v:
Genetics. 196:767-780
Steroid hormones trigger a wide variety of biological responses through stage- and tissue-specific activation of target gene expression. The mechanisms that provide specificity to systemically released pulses of steroids, however, remain poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f7605654b5ab7f51fbeafa67e2d324
https://doi.org/10.1534/genetics.113.159707
https://doi.org/10.1534/genetics.113.159707
Publikováno v:
Developmental Biology. 387:229-239
Sequential pulses of the steroid hormone ecdysone regulate the major developmental transitions in Drosophila, and the duration of each developmental stage is determined by the length of time between ecdysone pulses. Ecdysone regulates biological resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5294c34cdf34e4e202538cc3302a82f3
https://doi.org/10.1016/j.ydbio.2014.01.006
https://doi.org/10.1016/j.ydbio.2014.01.006