Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert J. Holbrook"'
Publikováno v:
Bioconjugate Chemistry. 29:3544-3549
We describe a new, and vastly superior approach for labeling spherical nucleic acid conjugates (SNAs) with diagnostic probes. SNAs have been shown to provide the unique ability to traverse the cell membrane and deliver surface conjugated DNA into cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e37e068a90341cc458997d5fea71ea
https://doi.org/10.1021/acs.bioconjchem.8b00504
https://doi.org/10.1021/acs.bioconjchem.8b00504
Publikováno v:
Journal of the American Chemical Society. 137:3379-3385
We describe a mechanism of light activation that initiates protein inhibitory action of a biologically inert Co(III) Schiff base (Co(III)-sb) complex. Photoinduced electron transfer (PET) occurs from a Ru(II) bipyridal complex to a covalently attache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de31f6f6c9067336b0132b3e74ba9a29
https://doi.org/10.1021/jacs.5b00342
https://doi.org/10.1021/jacs.5b00342
Autor:
Matthew C. Duch, Cameron J. Glasscock, Kevin T. Dam, Lisa M. Manus, Robert J. Holbrook, Matthew W. Rotz, Mark C. Hersam, Keith W. MacRenaris, Thomas J. Meade, Andy H. Hung, Nikhita D. Mansukhani
Publikováno v:
ACS Nano
The delivery of bioactive molecules into cells has broad applications in biology and medicine. Polymer-modified graphene oxide (GO) has recently emerged as a de facto noncovalent vehicle for hydrophobic drugs. Here, we investigate a different approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47efef56e79928295887ddcdfc479aa
http://europepmc.org/articles/PMC4212791
http://europepmc.org/articles/PMC4212791
Autor:
Matthew W. Rotz, Keith W. MacRenaris, Adam T. Preslar, Christiane E. Carney, Viktorie Reichova, Thomas J. Meade, Nikhil Rammohan, Robert J. Holbrook
Publikováno v:
Bioconjugate chemistry. 28(1)
In vivo cell tracking is vital for understanding migrating cell populations, particularly cancer and immune cells. Magnetic resonance (MR) imaging for long-term tracking of transplanted cells in live organisms requires cells to effectively internaliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b150e61b008d06ed281abd33928e333f
https://pubmed.ncbi.nlm.nih.gov/27537821
https://pubmed.ncbi.nlm.nih.gov/27537821
Autor:
Thomas J. Meade, Adam T. Preslar, Nikhil Rammohan, Matthew W. Rotz, Keith W. MacRenaris, Robert J. Holbrook
Pancreatic adenocarcinoma has a 5 year survival of approximately 3% and median survival of 6 months and is among the most dismal of prognoses in all of medicine. This poor prognosis is largely due to delayed diagnosis where patients remain asymptomat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e051ae4fa86903567e0dd605a104684
https://europepmc.org/articles/PMC5045863/
https://europepmc.org/articles/PMC5045863/
Autor:
Thomas J. Meade, Robert J. Holbrook, Robert A. Holmgren, Marie C. Heffern, Allison S. Harney, Ryan R. Hurtado
Publikováno v:
Molecular Pharmaceutics. 9:325-333
We describe the use of Co(III) Schiff base-DNA conjugates, a versatile class of research tools that target C2H2 transcription factors, to inhibit the Hedgehog (Hh) pathway. In developing mammalian embryos, Hh signaling is critical for the formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ff2397fe60c64802636746b2a7ce78
https://doi.org/10.1021/mp2005577
https://doi.org/10.1021/mp2005577
Autor:
Robert J. Holbrook, Marina G. Dickens, Katherine J. Franz, Lynne M. Hyman, Daniel T. Yang, Katie L. Ciesienski, Kathryn L. Haas
Publikováno v:
European Journal of Inorganic Chemistry. 2010:2224-2228
A novel platinum(II) photocaged complex called [Pt(cage)] has been prepared and characterized by X-ray crystallography. The complex contains a photolabile nitrophenyl group incorporated into the backbone of a tetradentate ligand that contains two pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945c3727dacdbcaefd06d3af61312361
https://doi.org/10.1002/ejic.201000098
https://doi.org/10.1002/ejic.201000098
Publikováno v:
Journal of the American Chemical Society. 135(35)
This paper describes the activation of a biologically inert Co(III) Schiff base [Co(III)-SB] complex to its protein inhibitor form by photoinduced electron transfer (PET) from a colloidal PbS quantum dot (QD, radii of 1.5–1.7 nm) to the cobalt cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cebe69b96101591b9fbdce42f7593cb
https://pubmed.ncbi.nlm.nih.gov/23931454
https://pubmed.ncbi.nlm.nih.gov/23931454
Autor:
Marie C. Heffern, Thomas J. Meade, Robert J. Holbrook, Mark A. Ratner, Lisa M. Manus, Lauren M. Matosziuk
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 42(11)
Cobalt(III) Schiff base complexes, such as [Co(acacen)L(2)](+), inhibit the function of Zn(II)-dependent proteins through dissociative exchange of the axial ligands with key histidine residues of the target protein. Consequently the efficacy of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9ac3df8f03798273473b6f68129bc5
https://pubmed.ncbi.nlm.nih.gov/23340849
https://pubmed.ncbi.nlm.nih.gov/23340849
Autor:
Robert J. Holbrook, Marie C. Heffern, Amanda L. Eckermann, Allison S. Harney, Lisa M. Manus, Tulay A. Atesin, Thomas J. Meade
Publikováno v:
Inorganic chemistry. 52(2)
The kinetic and thermodynamic ligand exchange dynamics are important considerations in the rational design of metal-based therapeutics and therefore, require detailed investigation. Co(III) Schiff base complex derivatives of bis(acetylacetone) ethyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e056f2048c2e4ddf22686c4e63685fb
https://pubmed.ncbi.nlm.nih.gov/23282130
https://pubmed.ncbi.nlm.nih.gov/23282130