Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Robert J. Highet"'
1
Hydrogen peroxide-mediated alteration of the heme prosthetic group of metmyoglobin to an iron chlorin product: Evidence for a novel oxidative pathway
Autor: Yoichi Osawa, Robert J. Cotter, Amina S. Woods, Robert J. Highet, Katsumi Sugiyama
Publikováno v: Proceedings of the National Academy of Sciences. 94:796-801
Treatment of metmyoglobin with H 2 O 2 is known to lead to the crosslinking of an active site tyrosine residue to the heme [Catalano, C. E., Y. S. Choe, and P. R. Ortiz de Montellano (1989) J. Biol. Chem. 264, 10534–10541]. We have found in this st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf03d3eb26f46794b13e41cd8ce3de99
https://doi.org/10.1073/pnas.94.3.796
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2
Structure of the novel heme adduct formed during the reaction of human hemoglobin with BrCCl3 in red cell lysates
Autor: Robert J. Highet, Charles L. Wilkins, Robert J. Cotter, Yoichi Osawa, Amina S. Woods, John A. Castoro, Christine S. Fellows, Carl A. Meyer
Publikováno v: Journal of Biological Chemistry. 269:15481-15487
It was previously shown that the reductive debromination of BrCCl3 to trichloromethyl radical by human hemoglobin leads to formation of dissociable altered heme products, two of which are identical to those formed from myoglobin and one which is nove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8382db13eb467f63d4acde3cc03bbe22
https://doi.org/10.1016/s0021-9258(17)40704-6
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4
Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac
Autor: Lance R. Pohl, Neil R. Pumford, Julio C. Davila, Robert J. Highet, Timothy G. Myers
Publikováno v: Chemical Research in Toxicology. 6:147-150
Serious idiosyncratic hepatic injury has been associated with the use of many nonsteroidal antiinflammatory drugs, including the widely prescribed agent diclofenac. In order to investigate the possibility that covalent protein adducts of reactive met
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19de52b96849f24ddccf795d931327d
https://doi.org/10.1021/tx00032a002
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5
The use of stable isotopes to identify reactive metabolites and target macromolecules associated with toxicities of halogenated hydrocarbon compounds
Autor: Robert J. Highet, Yoichi Osawa, Lance R. Pohl
Publikováno v: Xenobiotica. 22:1147-1156
1. Halogenated compounds, such as the inhalation anaesthetics, halothane and enflurane, and the chemicals chloroform, carbon tetrachloride, and bromotrichloromethane can cause hepatotoxicity, nephrotoxicity, and inactivation of cytochromes P-450. Eac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daa0c05873e314a825f3e4ba1828a3e
https://doi.org/10.3109/00498259209051868
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6
Characterization by NMR of the heme-myoglobin adduct formed during the reductive metabolism of BrCCl3. Covalent bonding of the proximal histidine to the ring I vinyl group
Autor: Robert J. Highet, Ad Bax, Lance R. Pohl, Yoichi Osawa
Publikováno v: Journal of Biological Chemistry. 266:3208-3214
The reductive debromination of BrCCl3 by ferrous deoxymyoglobin leads to the covalent bonding of the prosthetic heme to the protein. We have previously shown, by the use of peptide mapping and mass spectrometry, that histidine residue 93 is covalentl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b8178b9c258c5a10722b1163d4fa5c1
https://doi.org/10.1016/s0021-9258(18)49975-9
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8
Inactivation of horseradish peroxidase by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine
Autor: Yoichi Osawa, James R. Gillette, Robert J. Cotter, John F. Darbyshire, Robert J. Highet, Katsumi Sugiyama, Amina S. Woods
Publikováno v: Chemical research in toxicology. 7(6)
In the presence of H2O2, horseradish peroxidase (HRP) catalyzes the one-electron oxidation of a porphyrinogenic agent, 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP), leading to formation of an ethyl radical, inactivation of the enz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579506d2f2f0706a9ed7192bec78ca13
https://pubmed.ncbi.nlm.nih.gov/7696541
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9
Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione
Autor: Thomas W. Jones, Barbara A. Hill, Robert J. Highet, Terrence J. Monks, Serrine S. Lau
Publikováno v: Toxicology and applied pharmacology. 104(2)
We have previously demonstrated that administration of various benzoquinol-glutathione (GSH) conjugates to rats causes renal proximal tubular necrosis and the initial lesion appears to lie within that portion of the S3 segment within the outer stripe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3593432fc33f9af6e6bf600efd70af8
https://pubmed.ncbi.nlm.nih.gov/2363184
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10
Microbial hydroxylation of a dihydroartemisinin derivative
Autor: Robert J. Highet, Herman Ziffer, Dominique Marion, Yulin Hu
Publikováno v: Journal of the Chemical Society, Chemical Communications. :1176
The fungus Beauveria sulfurescens has been employed to convert the 14-methyl group of the phenylcarbamoyl of dihydroartemisinin to the corresponding 14-hydroxymethyl derivative; the structure of the product was established by mass and 2D NMR spectros
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fae298f800f485fd9d539af31b9706e4
https://doi.org/10.1039/c39910001176
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