Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Robert J. Hatch"'
Autor:
Han-Shen Tae, Kelly M. Smith, A. Marie Phillips, Kieran A. Boyle, Melody Li, Ian C. Forster, Robert J. Hatch, Robert Richardson, David I. Hughes, Brett A. Graham, Steven Petrou, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated Ih in brain slice experiments. However, evidence showing that GBP directly modulat
Externí odkaz:
https://doaj.org/article/3f9fcd99967a47b0be0f24a378bc8dff
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Gap junctions form electrical synapses that modulate neuronal activity by synchronizing action potential (AP) firing of cortical interneurons (INs). Gap junctions are thought to form predominantly within cortical INs of the same functional class and
Externí odkaz:
https://doaj.org/article/6f4868c23ff9432d9cb4093ff1016796
Autor:
Robert J. Hatch, Géza Berecki, Nikola Jancovski, Melody Li, Ben Rollo, Paymaan Jafar-Nejad, Frank Rigo, Kai Kaila, Christopher A. Reid, Steven Petrou
Publikováno v:
The Journal of Neuroscience. 43:1658-1667
Brain pH is a critical factor for determining neuronal activity, with alkalosis increasing and acidosis reducing excitability. Acid shifts in brain pH through the breathing of carbogen (5% CO2/95% O2) reduces seizure susceptibility in animal models a
Publikováno v:
Journal of Further and Higher Education. 47:450-464
Autor:
Kristopher M, Kahlig, Liam, Scott, Robert J, Hatch, Andrew, Griffin, Gabriel, Martinez Botella, Zoë A, Hughes, Marion, Wittmann
Publikováno v:
Epilepsia. 63:697-708
This study investigates the effects of PRAX-562 on sodium current (IInhibition of IPRAX-562 potently and preferentially inhibited persistent IPRAX-562 demonstrated robust preclinical anticonvulsant activity similar to CBZ but improved compared to LTG
Autor:
Alexander Bryson, Christopher A. Reid, Sean Hill, Christian Rössert, David B. Grayden, Steven Petrou, Robert J. Hatch, Samuel F. Berkovic, Bas-Jan Zandt
Publikováno v:
Proc Natl Acad Sci U S A
The binding of GABA to extra-synaptic GABAAreceptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present at low levels throughout the extracellular space of the brain, previous work ha
Autor:
Gregory A. Quaife-Ryan, Chun Yuen Chow, Nathan J. Palpant, Steven Petrou, Peter S. Macdonald, Glenn F. King, Enzo R. Porrello, Meredith A. Redd, Mark Hicks, Di Xia, Jacky Y. Suen, Sarah E. Scheuer, Yusuke Yoshikawa, Xiaoli Chen, Ling Gao, Melanie Y. White, Gabriel Cuellar-Partida, Stuart J. Cordwell, Walter G. Thomas, Ben Rollo, Jeanette E. Villanueva, James E. Hudson, Robert J. Hatch, Snezana Maljevic, Han Sheng Chiu, Yashutosh Joshi, Melissa E. Reichelt, Louise E. See Hoe, Mubarak A.H. Alzubaidi, John F. Fraser, Natalie J. Saez, Jason Nigel John Peart, Yuliangzi Sun
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the buildup of acidic metabolites results in decreased intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a87355930a63d2e18ca69d4c7ecfae
https://hdl.handle.net/10453/151624
https://hdl.handle.net/10453/151624
Autor:
Sarah E. Scheuer, Gregory A. Quaife-Ryan, Peter S. Macdonald, Jeanette E. Villanueva, Glenn F. King, Melissa E. Reichelt, Xiaoli Chen, Yusuke Yoshikawa, Ben Rollo, Jacky Y. Suen, Snezana Maljevic, Walter G. Thomas, James E. Hudson, Nathan J. Palpant, John F. Fraser, Steven Petrou, Natalie J. Saez, Ling Gao, Robert J. Hatch, Mubarak A.H. Alzubaidi, Louise E. See Hoe, Han Sheng Chiu, Jason Nigel John Peart, Yuliangzi Sun, Meredith A. Redd, Mark Hicks, Enzo R. Porrello, Melanie Y. White, Stuart J. Cordwell, Gabriel Cuellar-Partida
Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. Here we show that the proton-gated acid-sensing ion channel 1a (ASIC1a) plays a key role during cardiac i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5893930b39acce441f636581103622
Autor:
Jonathan G Crowston, P. van Wijngaarden, M.I.G. Lopez Sanchez, F Grus, Timothy D. Colgan, K Bell, Ian A. Trounce, Robert J. Hatch, Joseph Paul, Vicki Chrysostomou
Publikováno v:
Der Ophthalmologe. 116:14-17
Die Tatsache einer moglichen Visus- und Gesichtsfelderholung beim Glaukom ist ein bekanntes, wenn auch bisher wenig erforschtes Phanomen. Unser Ziel ist es, einen Einblick in die funktionelle Regeneration retinaler Ganglienzellen (RGZ) besonders nach
Publikováno v:
Acta Neuropathologica
Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer’s disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in transgen