Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert J. Halter"'
Autor:
Nicola J. Burrmann, Nathan P. Bowling, Robert J. Halter, Jonathan A. Hodges, Robert J. McMahon
Publikováno v:
The Journal of Organic Chemistry. 75:6382-6390
A variety of substituted pentadiynols, -diynals, and -diynones have been prepared en route to precursors to dialkynyl carbenes (R(1)-C≡C-C-C≡C-R(2)). In light of the marginal stability associated with these simple systems, several strategies were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f30ac84012ff4194be86b79a41ec3b
https://doi.org/10.1021/jo101125y
https://doi.org/10.1021/jo101125y
Autor:
Junghwan Oh, Robert J. Halter, Nathan T. Ihle, Robert Lemos, Garth Powis, Lynn Kirkpatrick, Peter Wipf, David L. Schwartz
Publikováno v:
Molecular Cancer Therapeutics. 8:94-100
The phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascade is an important component of the insulin signaling in normal tissues leading to glucose uptake and homeostasis and for cell survival signaling in cancer cells. Hyperglycemia is an on-targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49995864fdbd50cbfb9f053068c20a1
https://doi.org/10.1158/1535-7163.mct-08-0714
https://doi.org/10.1158/1535-7163.mct-08-0714
Autor:
Jonathan A. Hodges, Robert J. Halter, John F. Stanton, Christopher S Simmons, Randal A. Seburg, Robert J. McMahon, Nathan P. Bowling, Phillip S. Thomas
Publikováno v:
Journal of the American Chemical Society. 128:3291-3302
1-Diazo-2,4-pentadiyne (6a), along with both monodeuterio isotopomers 6b and 6c, has been synthesized via a route that proceeds through diacetylene, 2,4-pentadiynal, and 2,4-pentadiynal tosylhydrazone. Photolysis of diazo compounds 6a-c (lambda > 444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3fb1fbea4dc776cd0557bcfcce257c3
https://doi.org/10.1021/ja058252t
https://doi.org/10.1021/ja058252t
Autor:
Nathan T, Ihle, Ryan, Williams, Sherry, Chow, Wade, Chew, Margareta I, Berggren, Gillian, Paine-Murrieta, Daniel J, Minion, Robert J, Halter, Peter, Wipf, Robert, Abraham, Lynn, Kirkpatrick, Garth, Powis
Publikováno v:
Molecular Cancer Therapeutics. 3:763-772
We have developed biologically stable semisynthetic viridins as inhibitors of phosphoinositide (PtdIns)-3-kinases. The most active compound was PX-866 (acetic acid (1S,4E,10R,11R,13S,14R)-[4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644e177d8a9bb9db0b7d91e09e893f0
https://doi.org/10.1158/1535-7163.763.3.7
https://doi.org/10.1158/1535-7163.763.3.7
Publikováno v:
The Journal of Physical Chemistry B. 107:224-228
The reaction of acenaphthylene with the Si(001) surface has been investigated as a model system for understanding how complex π-systems interact with a π-bonded semiconductor surface. Scanning tunneling microscopy (STM) reveals that bonding occurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e274ca18163479ebbd4fb906a88ca2f8
https://doi.org/10.1021/jp0265844
https://doi.org/10.1021/jp0265844
Autor:
Robb J. Wilson, Robert L. Kuczkowski,‡ and, John F. Stanton, Robert J. McMahon, Robert J. Halter, Sean A. Peebles, Ryan L. Fimmen
Publikováno v:
Journal of the American Chemical Society. 122:939-949
An accurate gas-phase structure determination of cis-hex-3-ene-1,5-diyne (1), the parent molecule for the Bergman cyclization reaction, has been achieved through a combination of Fourier transform microwave spectroscopy and computational quantum chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11dd23fb237a682fde5b552afe8a7463
https://doi.org/10.1021/ja9934908
https://doi.org/10.1021/ja9934908
Autor:
Robert J. Halter, William L. Karney, Louise L. Stracener, Robert J. McMahon, and Claire Castro
Publikováno v:
The Journal of Organic Chemistry. 65:199-204
Ab initio (MP2, CCSD(T)) and density functional theory (BLYP, B3LYP) calculations provide insight concerning novel aspects of structure and bonding in cyclobutylidene (1). Singlet cyclobutylidene ((1)1) adopts a bicyclobutane-like structure (C(s) sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11ad517cfdfb4119fb3caad8bf6116e
https://doi.org/10.1021/jo9914925
https://doi.org/10.1021/jo9914925
Autor:
Nathan P. Bowling, Nicola J. Burrmann, Robert J. Halter, Jonathan A. Hodges, Robert J. McMahon
Publikováno v:
ChemInform. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f61c8d66ab30d6b017126e4cc6dc9f
https://doi.org/10.1002/chin.201105040
https://doi.org/10.1002/chin.201105040
Publikováno v:
Organic letters. 9(16)
The synthesis of a thiophene-containing analogue of halenaquinone was realized. Key steps include an alkynyl ketone−benzocyclobutane Diels−Alder reaction to construct the C,D-ring naphthalene subunit, a Heck cyclization to form the quaternary car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d28b6a7d494f491e08fb83edc0e24fa
https://pubmed.ncbi.nlm.nih.gov/17630756
https://pubmed.ncbi.nlm.nih.gov/17630756
Autor:
Nathan P, Bowling, Robert J, Halter, Jonathan A, Hodges, Randal A, Seburg, Phillip S, Thomas, Christopher S, Simmons, John F, Stanton, Robert J, McMahon
Publikováno v:
Journal of the American Chemical Society. 128(10)
1-Diazo-2,4-pentadiyne (6a), along with both monodeuterio isotopomers 6b and 6c, has been synthesized via a route that proceeds through diacetylene, 2,4-pentadiynal, and 2,4-pentadiynal tosylhydrazone. Photolysis of diazo compounds 6a-c (lambda444 nm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5203e9e894b3ff5200817455b082401
https://pubmed.ncbi.nlm.nih.gov/16522111
https://pubmed.ncbi.nlm.nih.gov/16522111