Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Robert J. Gould"'
Publikováno v:
Health of People, Health of Planet and Our Responsibility ISBN: 9783030311247
To achieve the goal of the Paris Climate Agreement—limiting global warming to no more than 2 °C (and if possible 1.5 °C)—and thereby avoid the most harmful impacts of climate change to human health and well-being, the global community must dram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630647820a10053e2ea5b05f83bcf7bb
https://doi.org/10.1007/978-3-030-31125-4_33
https://doi.org/10.1007/978-3-030-31125-4_33
Publikováno v:
Environmental Research Letters. 16:011002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4466ca7955779f22f535122c1b30153b
https://doi.org/10.1088/1748-9326/abca66
https://doi.org/10.1088/1748-9326/abca66
Autor:
Gail Murphy, Joseph J. Lynch, Lawrence I. Deckelbaum, Frederick L. Sax and, George D. Hartman, Man-Wai Lo, Melissa S. Egbertson, Robert J. Gould, Eliav Barr, Wasyl Halczenko, Jacquelynn J. Cook, Bohumil Bednar, Mark E. Duggan
Publikováno v:
Cardiovascular Drug Reviews. 17:199-224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c80cee48cfb05b00fd056a4f28f28da4
https://doi.org/10.1111/j.1527-3466.1999.tb00015.x
https://doi.org/10.1111/j.1527-3466.1999.tb00015.x
Autor:
Peter J. Sadler, Haimei Chen, Viktor Brabec, Robert J. Gould, Alice Dawson, Juraj Bella, John Parkinson, Olga Novakova, Fuyi Wang, Simon Parsons
Publikováno v:
Chen, H M, Parkinson, J A, Novakova, O, Bella, J, Wang, F Y, Dawson, A, Gould, R, Parsons, S, Brabec, V & Sadler, P J 2003, ' Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers ', Proceedings of the National Academy of Sciences, vol. 100, no. 25, pp. 14623-14628 . https://doi.org/10.1073/pnas.2434016100
Organometallic chemistry offers novel concepts in structural diversity and molecular recognition that can be used in drug design. Here, we consider DNA recognition by η 6 -arene Ru(II) anticancer complexes by an induced-fit mechanism. The stereochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935558fcf13d15e89637e11809febaf9
https://doi.org/10.1073/pnas.2434016100
https://doi.org/10.1073/pnas.2434016100
Autor:
Robert J. Gould, Edward Maibach
Publikováno v:
Science (New York, N.Y.). 344(6181)
[Figure][1] CREDIT: TOMASZ SIENICKI/WIKIMEDIA COMMONS In 1962, Luther Terry, the Surgeon General of the Public Health Service, established the Surgeon General's Advisory Committee on Smoking and Health. On 11 January 1964, he released the committee's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27739922e555dc8b39dc09b383c8f984
https://pubmed.ncbi.nlm.nih.gov/24744356
https://pubmed.ncbi.nlm.nih.gov/24744356
Autor:
Michelle K. Clements, Robert J. Gould, Qingyun Liu, Zhizhen Zeng, Marlene A. Jacobson, John J. Mallee, Jilly F. Evans, David J. Figueroa, Christopher P. Austin, William J. Martin, Xiao-Ming Guan, Douglas Bomford, Ruiping Wang, David L. Williams, Hong Yu, Terrence P. McDonald, Qingping Jiang
Publikováno v:
Journal of Biological Chemistry. 276:36961-36969
The two mammalian neuropeptides NPFF and NPAF have been shown to have important roles in nociception, anxiety, learning and memory, and cardiovascular reflex. Two receptors (FF1 and FF2) have been molecularly identified for NPFF and NPAF. We have now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f678256ae9f0cd425a5a0870d8073756
https://doi.org/10.1074/jbc.m105308200
https://doi.org/10.1074/jbc.m105308200
Autor:
Laura E. Kakuk, Wen Li, Min Han, Robert J. Gould, Michael L. Metzker, Radha Ayyagari, David J. Figueroa, Konstantin Petrukhin, Yang Li, Ian M. MacDonald, Marina Kniazeva, Rando Allikmets, Christopher P. Austin, Zhengya Yu, Zhenglin Yang, Pamela S. Lagali, Paul A. Sieving, Donald J. Zack, Paul Wong, Kang Zhang
Publikováno v:
Nature Genetics. 27:89-93
Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased visual acuity, macular atrophy and extensive fundus flecks. Genetic mapping da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142471fd1d195b34d47216576cfe9a8c
https://doi.org/10.1038/83817
https://doi.org/10.1038/83817
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 20:2309-2315
Abstract —Thrombosis resulting from blood platelet aggregation via glycoprotein (GP) IIb/IIIa receptor activation triggers the local release of vasoactive substances. Therefore, inhibition of these receptors could affect coronary vasoactive functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b168485db2165f422b1e01871466f6af
https://doi.org/10.1161/01.atv.20.10.2309
https://doi.org/10.1161/01.atv.20.10.2309
Autor:
Elizabeth Hand, Aaron Barchowsky, Jeffrey S. Barrett, Thorir D. Bjornsson, Daniel Farrell, Robert J. Gould, Howard E. Greenberg, Deborah Panebianco, Michael R. Goldberg, Paul Wissel, Lisa Gillen
Publikováno v:
The Journal of Clinical Pharmacology. 40:496-507
MK-852, a cyclic heptapeptide, is a potent platelet fibrinogen receptor antagonist. When administered to normal healthy male subjects by 1- and 4-hour constant rate intravenous infusions, it provides a generally well-tolerated and reversible means of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688d6c6827f99e2b6694047402423611
https://doi.org/10.1177/00912700022009116
https://doi.org/10.1177/00912700022009116
Autor:
Patricia A. Jumes, Bohumil Bednar, Rodney A. Bednar, George D. Hartman, Marie A. Holahan, Robert J. Gould, Jacquelynn J. Cook, Michael E. Cunningham
Publikováno v:
Blood. 94:587-599
Most clinical trials with fibrinogen receptor antagonists (FRAs) have been associated with thrombocytopenia. This report describes the occurrence of thrombocytopenia in one chimpanzee and one rhesus monkey upon administration of potent FRAs. Chimpanz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014fabc66f2d47a0f381a5b021a5e5cf
https://doi.org/10.1182/blood.v94.2.587
https://doi.org/10.1182/blood.v94.2.587