Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Robert J. Gooding"'
Autor:
Ami G. Sangster, Robert J. Gooding, Andrew Garven, Hamid Ghaedi, David M. Berman, Scott K. Davey
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Muscle Invasive bladder cancer is known to have an abundance of mutations, particularly in DNA damage response and chromatin modification genes. The role of these mutations in the development and progression of the disease is not well understood. How
Externí odkaz:
https://doaj.org/article/2ef425f0f5784dddba3c0eb348190ee6
Autor:
Céline S.C. Hardy, Hamid Ghaedi, Ava Slotman, Gottfrid Sjödahl, Robert J. Gooding, David M. Berman, Chelsea L. Jackson
Publikováno v:
Journal of Histochemistry & Cytochemistry. 70:357-375
Transcriptomic and proteomic profiling classify bladder cancers into luminal and basal molecular subtypes, with controversial prognostic and predictive associations. The complexity of published subtyping algorithms is a major impediment to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e15d6d73921f97767aac8c9dcdd0f3
https://doi.org/10.1369/00221554221095530
https://doi.org/10.1369/00221554221095530
Autor:
Ava Slotman, Minqi Xu, Katherine Lindale, Céline Hardy, Dan Winkowski, Regan Baird, Lina Chen, Priti Lal, Theodorus van der Kwast, Chelsea L. Jackson, Robert J. Gooding, David M. Berman
Publikováno v:
Laboratory Investigation. 103:100155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24be825ddd3caec463fc8a3d1a31fa7
https://doi.org/10.1016/j.labinv.2023.100155
https://doi.org/10.1016/j.labinv.2023.100155
Autor:
David M. Berman, Chelsea L. Jackson, Robert J. Gooding, David Robert Siemens, Kevin Ym Ren, Gottfrid Sjödahl, Kash Visram, Céline Hardy, Lina Chen, Vanessa F Bratti, Jeannette Johnstone
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 2, Pp 143-154 (2022)
Intrinsic molecular subtypes may explain marked variation between bladder cancer patients in prognosis and response to therapy. Complex testing algorithms and little attention to more prevalent, early‐stage (non‐muscle invasive) bladder cancers (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fa31cb2bac1edbb7035f6350538713
https://pubmed.ncbi.nlm.nih.gov/34697907
https://pubmed.ncbi.nlm.nih.gov/34697907
Autor:
Chelsea L. Jackson, David M. Berman, Hamid Ghaedi, Ava Slotman, Gottfrid Sjödahl, Céline Hardy, Robert J. Gooding
Transcriptomic and proteomic profiling reliably classifies bladder cancers into luminal and basal molecular subtypes. Based on their prognostic and predictive associations, these subtypes may improve clinical management of bladder cancers. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30d0e1abd8b3bc48f633ffd3aae8717b
https://doi.org/10.1101/2021.08.06.455345
https://doi.org/10.1101/2021.08.06.455345
Autor:
Robert J. Gooding, Sam Abernethy
Publikováno v:
Physica A: Statistical Mechanics and its Applications. 507:268-277
We examine the importance of chaotic attractors when modelling non-metastatic tumour growth using a model in which cells come in three types: host, immune, and tumour. The relationships between these cell populations are derived from the law of mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75289a86549deeebbd78492010b6c34
https://doi.org/10.1016/j.physa.2018.05.093
https://doi.org/10.1016/j.physa.2018.05.093
Autor:
Laura A. Lee, Tanya Sack, Robert J. Gooding, Rachel Dunn, Joseph L. Chin, Atsunari Kawashima, Audrey Ellis, Karl-Philippe Guérard, Elizabeth Marra, Glenn Bauman, Vinolia Arthur-Hayward, Chelsea L. Jackson, Fadi Brimo, Simone Chevalier, Khurram M. Siddiqui, David M. Berman, Karen Mackie, Thomas Wessel, Dan Dion, Tamara Jamaspishvili, Suzanne Boursalie, Anna Ying-Wah Lee, Lee-Anne Pickard, Jacques Lapointe, Palak G. Patel, Eleonora Scarlata, Nathan E How, John M. S. Bartlett, John B. A. Okello, Khalil Hetou, Madeleine Moussa, Paul C. Boutros
Publikováno v:
Medical Biophysics Publications
Patel, P G, Wessel, T, Kawashima, A, Okello, J B, Jamaspishvili, T, Guerard, K-P, Lee, L, Ying-Wah Lee, A, E. How, N, Dion, D, Scarlata, E, L. Jackson, C, Boursalie, S, Sack, T, Dunn, R, Moussa, M, Mackie, K, Ellis, A, Marra, E, Chin, J, Siddiqui, K, Hetou, K, Pickard, L-A, Arthur Hayward, V, Bauman, G, Chevalier, S, Brimo, F, Boutros, P, Lapointe, J, Bartlett, J, J. Gooding, R & M. Berman, D 2019, ' A three gene DNA methylation biomarker accurately classifies early stage prostate cancer ', Prostate . https://doi.org/10.1002/pros.23895
Patel, P G, Wessel, T, Kawashima, A, Okello, J B, Jamaspishvili, T, Guerard, K-P, Lee, L, Ying-Wah Lee, A, E. How, N, Dion, D, Scarlata, E, L. Jackson, C, Boursalie, S, Sack, T, Dunn, R, Moussa, M, Mackie, K, Ellis, A, Marra, E, Chin, J, Siddiqui, K, Hetou, K, Pickard, L-A, Arthur Hayward, V, Bauman, G, Chevalier, S, Brimo, F, Boutros, P, Lapointe, J, Bartlett, J, J. Gooding, R & M. Berman, D 2019, ' A three gene DNA methylation biomarker accurately classifies early stage prostate cancer ', Prostate . https://doi.org/10.1002/pros.23895
Background We identify and validate accurate diagnostic biomarkers for prostate cancer through a systematic evaluation of DNA methylation alterations. Materials and methods We assembled three early prostate cancer cohorts (total patients = 699) from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ff13d6577bd2a95ff43c8114d9bb6f
https://pubmed.ncbi.nlm.nih.gov/31433512
https://pubmed.ncbi.nlm.nih.gov/31433512
Publikováno v:
Urologic Oncology: Seminars and Original Investigations. 38:906
Introduction Luminal/basal molecular subtyping in muscle-invasive bladder cancer (MIBC) has shown important relationships to prognosis and chemosensitivity, where tumours of the basal subtype have been reported to be more aggressive, yet more sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4094ff2c77787065da4fa0819ef69d42
https://doi.org/10.1016/j.urolonc.2020.10.054
https://doi.org/10.1016/j.urolonc.2020.10.054
MicroRNA-206 suppresses TGF-β signalling to limit tumor growth and metastasis in lung adenocarcinoma
Autor:
Peter Truesdell, Kathleen Watt, Daniel Newsted, Adrianna Majewski, Elena Voorand, Neil Renwick, Andrew W.B. Craig, Thomas Tuschl, Robert J. Gooding, Binchen Yao
Publikováno v:
Cellular signalling. 50
MicroRNA-206 (miR-206) has demonstrated tumor suppressive effects in a variety of cancers. Numerous studies have identified aberrantly expressed targets of miR-206 that contribute to tumor progression and metastasis, however, the broader gene-network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd79586d771adb0fe6e4f8a02f058028
https://pubmed.ncbi.nlm.nih.gov/29935234
https://pubmed.ncbi.nlm.nih.gov/29935234
Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections
Autor:
A. Evans, Ming-Sound Tsao, Ciro Silveira Pereira, Jennifer Good, Paulo Nuin, Olga Ludkovski, Alexander Boag, Robert J. Gooding, Maisa Yoshimoto, Jean McGowan-Jordan, Jeremy A. Squire
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A variety of laboratory methods are available for the detection of deletions of tumor suppressor genes and losses of their proteins. The clinical utility of fluorescence in situ hybridization (FISH) for the identification of deletions of tumor suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0753ce0bec898c45081ddd725846a224