Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Robert J. Goldstone"'
Autor:
Michael J. Ormsby, Síle A. Johnson, Nuria Carpena, Lynsey M. Meikle, Robert J. Goldstone, Anne McIntosh, Hannah M. Wessel, Heather E. Hulme, Ceilidh C. McConnachie, James P.R. Connolly, Andrew J. Roe, Conor Hasson, Joseph Boyd, Eamonn Fitzgerald, Konstantinos Gerasimidis, Douglas Morrison, Georgina L. Hold, Richard Hansen, Daniel Walker, David G.E. Smith, Daniel M. Wall
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2297-2305.e5 (2020)
Summary: Propionic acid (PA) is a bacterium-derived intestinal antimicrobial and immune modulator used widely in food production and agriculture. Passage of Crohn’s disease-associated adherent-invasive Escherichia coli (AIEC) through a murine model
Externí odkaz:
https://doaj.org/article/c67d7647d1fe4b1ebd8cd8c4b4517135
Autor:
James P. R. Connolly, Sabrina L. Slater, Nicky O’Boyle, Robert J. Goldstone, Valerie F. Crepin, David Ruano-Gallego, Pawel Herzyk, David G. E. Smith, Gillian R. Douce, Gad Frankel, Andrew J. Roe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Infection of mice with Citrobacter rodentium is a common model of infection with attaching-and-effacing pathogens. Here, Connolly et al. analyse the transcriptome of C. rodentium during mouse infection, showing host-induced coordinated upregulation o
Externí odkaz:
https://doaj.org/article/b6965592be8f4c16ab3622e53a3e14e5
Autor:
Justin J. J. van der Hooft, Robert J. Goldstone, Susan Harris, Karl E. V. Burgess, David G. E. Smith
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Since its first isolation a century ago, the gut inhabitant Escherichia coli strain Nissle 1917 has been shown to have probiotic activities; however, it is yet not fully elucidated which differential factors play key roles in its beneficial interacti
Externí odkaz:
https://doaj.org/article/3c07f394ecef40fda06c5cd2e8b55fa5
Autor:
Susan Harris, Marta J. Piotrowska, Robert J. Goldstone, Ruby Qi, Geoffrey Foster, Ulrich Dobrindt, Jean-Yves Madec, Charlotte Valat, Francesco V. Rao, David G. E. Smith
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Bacterial surface polysaccharides play significant roles in fitness and virulence. In Gram-negative bacteria such as Escherichia coli, major surface polysaccharides are lipopolysaccharide (LPS) and capsule, representing O- and K-antigens, respectivel
Externí odkaz:
https://doaj.org/article/01ea173f77324b60a623daff796a3b33
Autor:
Shlomo E. Blum, Robert J. Goldstone, James P. R. Connolly, Maryline Répérant-Ferter, Pierre Germon, Neil F. Inglis, Oleg Krifucks, Shubham Mathur, Erin Manson, Kevin Mclean, Pascal Rainard, Andrew J. Roe, Gabriel Leitner, David G. E. Smith
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Escherichia coli are major bacterial pathogens causing bovine mastitis, a disease of great economic impact on dairy production worldwide. This work aimed to study the virulence determinants of mammary pathogenic E. coli (MPEC). By whole-geno
Externí odkaz:
https://doaj.org/article/adf8534cbb094e8e93aeaeafbec91e0a
Autor:
James P. R. Connolly, Sabrina L. Slater, Nicky O’Boyle, Robert J. Goldstone, Valerie F. Crepin, David Ruano-Gallego, Pawel Herzyk, David G. E. Smith, Gillian R. Douce, Gad Frankel, Andrew J. Roe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in the spelling of the author David Ruano-Gallego, which was incorrectly given as David R. Gallego. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/3c7d3a9004e84e9fa8e7699baf6f939b
Autor:
Christopher J. Neill, Humphrey H. P. Yiu, Elizabeth C. H. T. Lau, Theodore B. Henry, David Smith, Robert J. Goldstone, Susan Harris
Publikováno v:
ACS Infectious Diseases. 6:2959-2969
The continued emergence and spread of antimicrobial resistance (AMR), particularly multidrug resistant (MDR) bacteria, are increasing threats driving the search for additional and alternative antimicrobial agents. The World Health Organization (WHO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::103dbdd66b4656443a8c8e31c92f312d
https://doi.org/10.1021/acsinfecdis.0c00425
https://doi.org/10.1021/acsinfecdis.0c00425
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination
Autor:
Bryan Williams, Gavin Kelly, Mary Wu, Yenting Ngai, Vincenzo Libri, Saira Hussain, Ruth Harvey, Emine Hatipoglu, Andrew Riddell, Chelsea Sawyer, Rodney S. Daniels, Charles Swanton, Michael Howell, Philip Hobson, Karen Ambrose, Sonia Gandhi, Steve Hindmarsh, Robert J. Goldstone, Steve Gamblin, Emma C Wall, David L.V. Bauer, Rupert Beale, George Kassiotis, Jerome Nicod, Scott Warchal
Publikováno v:
Lancet (London, England)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0ec26775e6c2128fa6e2f7b261e9fd
https://pubmed.ncbi.nlm.nih.gov/34090624
https://pubmed.ncbi.nlm.nih.gov/34090624
Autor:
Sebastian Deindl, Christopher D.O. Cooper, Lucia Sommerova, Ellie Herbert, Harshil Patel, Antonia Tomás-Loba, Stephen J. Pettitt, Ivan Ahel, Tohru Takaki, Robert J. Goldstone, Gordon Stamp, Kasper Fugger, Phil Ruis, Stephen C. West, Rachel Brough, Roberto Bellelli, Dragana Ahel, Christopher J. Lord, Graeme Hewitt, Laura C. Lehmann, Valerie Borel, J. Ross Chapman, Kang Zhu, Aleksandra Vancevska, Simon J. Boulton, Deborah Schneider-Luftman, Sandra Segura-Bayona
Publikováno v:
Molecular Cell
Repisalud
Instituto de Salud Carlos III (ISCIII)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Summary Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2174f57c21d002678255af3abeae011
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430412
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430412
Autor:
Kiran Gulati, Amy Strange, Laura Cubitt, Ana Cardoso, Charles Swanton, Jerome Nicod, Mike Hubank, Margaret Crawford, David Moore, James I. MacRae, Enzo Z. Poirier, Amin Oomatia, Simon Caidan, Eleni Nastouli, Robert J. Goldstone, Richard D. Byrne, Sam Barrell, Philip A. Walker, Wei-Ting Lu, Michael Howell, Caetano Reis e Sousa, Ming Jiang, Michael D. Buck, Steve Hindmarsh, Sonia Gandhi, Jessica Olsen, Davin Miller, Mary Wu, Anett Rideg, Steve Gamblin, Ok-Ryul Song, Rachael Instrell, George Kassiotis, Johnathan Canton, Paul Grant, Bruno Frederico, Nicola O’Reilly, Rupert Beale, Iana Martini, Luke Nightingale, Samra Turajlic
The ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in colla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3525aaeaff9b7cec89e621d0b4dffe2
https://doi.org/10.1101/2020.06.29.20142430
https://doi.org/10.1101/2020.06.29.20142430