Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Robert J. Francis"'
Autor:
Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J. Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pa
Externí odkaz:
https://doaj.org/article/0bdbc34a3c9f4aa9acf1c9f0c03b6ceb
Autor:
Chrysi Sergaki, Saba Anwar, Martin Fritzsche, Ryan Mate, Robert J. Francis, Kirsty MacLellan-Gibson, Alastair Logan, Gregory C. A. Amos
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Effective standardisation of the microbiome field is essential to facilitate global translational research and increase the reproducibility of microbiome studies. In this study, we describe the development and validation of a whol
Externí odkaz:
https://doaj.org/article/d452701d9aba420d9e94cfa3496b2ad2
Autor:
Robert J. Francis, Gillian Robb, Lee McCann, Bhagwati Khatri, James Keeble, Belinda Dagg, Brad Amos, Francisco J. Salguero, Mei Mei Ho, Anwen Bullen, Gail McConnell, Kirsty MacLellan-Gibson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Tuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D me
Externí odkaz:
https://doaj.org/article/c753bc9f75174c4195e6c28918b47a23
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 161-171 (2020)
Recent clinical trials are evaluating induced pluripotent stem cells (iPSCs) as a cellular therapy in the field of regenerative medicine. The widespread clinical utility of iPSCs is expected to be realized using allogeneic cells that have undergone t
Externí odkaz:
https://doaj.org/article/5c6b92241d164d1ba0830acfadee358e
Autor:
Robert J. Francis, Deborah Ferguson, Sarah Kempster, Joanna Hall, Neil Berry, Kirsty MacLellan-Gibson
Publikováno v:
Histochemistry and Cell Biology. 158:383-388
Eosin Y is a common stain in histology. Although usually used for colourimetric imaging where the dye is used to stain pink/red a range of structures in the tissue, Eosin Y is also a fluorochrome, and has been used in this manner for decades. In this
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 161-171 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 161-171 (2020)
Recent clinical trials are evaluating induced pluripotent stem cells (iPSCs) as a cellular therapy in the field of regenerative medicine. The widespread clinical utility of iPSCs is expected to be realized using allogeneic cells that have undergone t
Autor:
Chrysi Sergaki, Saba Anwar, Martin Fritzsche, Ryan Mate, Robert J. Francis, Kirsty MacLellan-Gibson, Alastair Logan, Gregory C. A. Amos
Publikováno v:
Microbiome. 10(1)
Background Effective standardisation of the microbiome field is essential to facilitate global translational research and increase the reproducibility of microbiome studies. In this study, we describe the development and validation of a whole cell re
Autor:
Anwen Bullen, James Keeble, Brad Amos, Lee McCann, Bhagwati Khatri, Robert J. Francis, Gillian Robb, Francisco J. Salguero, Belinda Dagg, Gail McConnell, Mei Mei Ho, Kirsty MacLellan-Gibson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Tuberculosis (TB) preclinical testing relies on in vivo models including the mouse aerosol challenge model. The only method of determining colony morphometrics of TB infection in a tissue in situ is two-dimensional (2D) histopathology. 2D measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27af17ae509ce524c2d312c29f534125
https://strathprints.strath.ac.uk/75096/1/Francis_etal_SR_2020_three_dimensional_in_situ_morphometrics_of_mycobacterium_tuberculosis_infection.pdf
https://strathprints.strath.ac.uk/75096/1/Francis_etal_SR_2020_three_dimensional_in_situ_morphometrics_of_mycobacterium_tuberculosis_infection.pdf
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Neutrophils are pivotal players in immune defence which includes a process of release of histones and DNA as neutrophil extracellular traps (NETs). Histones, while toxic to invading pathogens, also kill host cells, including neutrophils. Bacteria hav
Autor:
Azhar Maqbool, Lewis Hardy, Craig Thelwell, Helen Philippou, Sophie Cherrington, Robert J. Francis
Publikováno v:
Access Microbiology. 2
Background: Fibrin formation is an essential part of innate immunity, sealing off infections to limit bacterial spreading.The surface-anchored M1 protein is a major virulence determinant of Group A streptococcus (GAS). During early infection M1 is cl