Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert J. Eckner"'
Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase
Autor:
Maret Panzenbeck, Mario G. Cardozo, Robert M. Tolbert, Jeffrey D. Peterson, Susan Lukas, Stephen Jacober, Robert J. Eckner, Gregory W. Peet, Anthony S. Prokopowicz, Carl A. Busacca, Suresh R. Kapadia, Scott Jakes, Tina Morwick, Roger J. Snow, Rosemarie Sellati, Yong Dong, Matt Aaron Tschantz, Neil Moss
Publikováno v:
Journal of Medicinal Chemistry. 45:3394-3405
An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5'-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb66ed0ff6ce36eb079aaec851fb78a
https://doi.org/10.1021/jm020113o
https://doi.org/10.1021/jm020113o
Autor:
Yong Wang, Anthony S. Prokopowicz, Suresh R. Kapadia, Matt Aaron Tschantz, Maret Panzenbeck, Jonathan Tan, Pla Xiong, John P. Wolak, Xiao-Jun Wang, Susan Pav, Susan Lukas, Scott Jakes, Tina Morwick, Mario G. Cardozo, Usha R. Patel, Tanja Butz, Gregory W. Peet, Hidenori Takahashi, Neil Moss, Robert J. Eckner, Jeffrey D. Peterson, Abdelhakim Hammach, Mohammed A. Kashem, Daniel R. Goldberg, Jessica Huang, Roger J. Snow, Rosemarie Sellati
Publikováno v:
Journal of medicinal chemistry. 46(8)
The tyrosine kinase p56lck (lck) is essential for T cell activation; thus, inhibitors of lck have potential utility as autoimmune agents. Our initial disclosure of a new class of lck inhibitors based on the phenylaminoimidazoisoquinolin-9-one showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eaf37bb87705b676ad771829aadb77
https://pubmed.ncbi.nlm.nih.gov/12672234
https://pubmed.ncbi.nlm.nih.gov/12672234
Autor:
Simon J. Coutts, Robert J. Eckner, Johanna A. Griffin, Joe C. Wu, Peter R. Farina, Gregory W. Peet
Publikováno v:
Biochemistry. 34(21)
An N1 strain of influenza A virus neuraminidase (A/WSN/33 NA) was purified and used to screen for inhibitors. As a result, a well-known tuberculostatic, 4'-formylacetanilide thiosemicarbazone (or thiacetazone), was identified. Thiacetazone is a non-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0251a03a370d706b92a633900a27e9
https://pubmed.ncbi.nlm.nih.gov/7539292
https://pubmed.ncbi.nlm.nih.gov/7539292
Autor:
Vincent J. Merluzzi, Karl D. Hargrave, Mark Labadia, Karl Grozinger, Mark Skoog, Joseph C. Wu, Cheng-Kon Shih, Kristine Eckner, Susan Hattox, Julian Adams, Alan S. Rosenthal, Ronald Faanes, Robert J. Eckner, Richard A. Koup, John L. Sullivan
Publikováno v:
Science (New York, N.Y.). 250(4986)
A series of dipyridodiazepinones have been shown to be potent inhibitors of human immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT). One compound, BI-RG-587, had a Ki of 200 nanomolar for inhibition of HIV-1 RT that was noncompetitive with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2f8aee19211de6f95a718103565f3b
https://pubmed.ncbi.nlm.nih.gov/1701568
https://pubmed.ncbi.nlm.nih.gov/1701568
Publikováno v:
The Journal of Experimental Medicine
Resistance to malignant erythropoiesis induced by Friend spleen focus-forming virus and resistance to marrow stem cell allografts are under genetic control. Strains of mice, e.g., C57BL/6 and B10.D2, which are homozygous for resistance at the Fv-2 lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f731618f5128d95e831745aca1022a
https://doi.org/10.1084/jem.139.5.1093
https://doi.org/10.1084/jem.139.5.1093
Publikováno v:
Journal of Virology. 61:2631-2638
To determine whether hemopoietic cells infected with Friend polycythemia-inducing spleen focus-forming virus (SFFVp) are conserved or suppressed via natural surveillance in leukemia-resistant adult mice, we engrafted C57BL/6 recipients with isologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c16f4703e657504778af92884c9b3c
https://doi.org/10.1128/jvi.61.8.2631-2638.1987
https://doi.org/10.1128/jvi.61.8.2631-2638.1987
Autor:
Kristine L. Hettrick, Robert J. Eckner
Publikováno v:
The Journal of Experimental Medicine
A latent form of persistent infection can be established in susceptible adult mice inoculated with a preparation of defective Friend spleen focus-forming virus (SFFV) purified free from standard leukemia-inducing helper virus (LLV-F). SFFV persistenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f27a7120ba173e2ea12cc6e707ee70
https://doi.org/10.1084/jem.149.2.340
https://doi.org/10.1084/jem.149.2.340
Autor:
Richard A. Steeves, Robert J. Eckner
Publikováno v:
Journal of Experimental Medicine. 136:832-850
Coinfection of neonatal BALB/c mice with helper-dependent Friend spleen focus-forming virus (SFFV), as contained in the Friend virus (FV) complex, and antigenically distinct Moloney leukemia virus (MolLV) resulted in the recovery of a MolLV pseudotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::290d17f45d83cb86b5f52d5a191448f2
https://doi.org/10.1084/jem.136.4.832
https://doi.org/10.1084/jem.136.4.832
Publikováno v:
Science. 225:630-632
Transmissible retroviruses encoding human hypoxanthine phosphoribosyltransferase (HPRT) were used to infect mouse bone marrow cells in vitro, and the infected cells were transplanted into mice. Both active human HPRT-protein and chronic HPRT-virus pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a342e05dd1d906568b663a0161ecef2
https://doi.org/10.1126/science.6377498
https://doi.org/10.1126/science.6377498
Autor:
Hatsumi Nagasawa, William C. Moloney, Abraham Karpas, Giulia Colletta, Sandra Boschetti, Joel S. Greenberger, Ralph R. Weichselbaum, Robert J. Eckner, Wolfram Ostertag
Publikováno v:
Virology. 105(2)
Three clonally derived sublines of acute promyelocytic leukemia (APML) induced in mouse long-term marrow cultures by Friend leukemia virus (FLV) were examined for release of spleen focus-forming virus (SFFV) and differentiation to mature granulocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5775eaefb427149dbce53f54f4880944
https://pubmed.ncbi.nlm.nih.gov/6932782
https://pubmed.ncbi.nlm.nih.gov/6932782