Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert J. Dinsdale"'
Autor:
Samantha J. Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios, Robert J. Dinsdale, Christine S.-M. Lee, Natalie S. Poulter, Robert K. Andrews, Peter Hampson, Christopher M. Wearn, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Woei Ming Lee, Tariq Iqbal, Naiem Moiemen, Steve P. Watson, Cécile Oury, Paul Harrison, Elizabeth E. Gardiner
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 240-251 (2018)
Abstract: Soluble glycoprotein VI (sGPVI) is shed from the platelet surface and is a marker of platelet activation in thrombotic conditions. We assessed sGPVI levels together with patient and clinical parameters in acute and chronic inflammatory cond
Externí odkaz:
https://doaj.org/article/2548f9d08ed64c8daa500e2cf9e58b32
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Major traumatic injury induces significant remodeling of the circulating neutrophil pool and loss of bactericidal function. Although a well-described phenomenon, research to date has only analyzed blood samples acquired post-hospital admission, and t
Externí odkaz:
https://doaj.org/article/41032cf9fcdc4f90b9c762a6fb8045de
Autor:
Jon Hazeldine, David N Naumann, Emma Toman, David Davies, Jonathan R B Bishop, Zhangjie Su, Peter Hampson, Robert J Dinsdale, Nicholas Crombie, Niharika Arora Duggal, Paul Harrison, Antonio Belli, Janet M Lord
Publikováno v:
PLoS Medicine, Vol 14, Iss 7, p e1002338 (2017)
BackgroundAlmost all studies that have investigated the immune response to trauma have analysed blood samples acquired post-hospital admission. Thus, we know little of the immune status of patients in the immediate postinjury phase and how this might
Externí odkaz:
https://doaj.org/article/8e3126ff3320433aa64702b58665d046
Autor:
David N Naumann, Jon Hazeldine, Robert J Dinsdale, Jon R Bishop, Mark J Midwinter, Paul Harrison, Sam D Hutchings, Janet M Lord
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189870 (2017)
Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have been used to indicate endotheliopathy, and are associated with inflammation, coagul
Externí odkaz:
https://doaj.org/article/b16dff78aebd43e79bd0fa0d71612919
Autor:
David N Naumann, Jonathan R B Bishop, Janet M. Lord, Paul Harrison, Animesh Acharjee, Robert J. Dinsdale, Jon Hazeldine
Publikováno v:
Burns & Trauma
Background Traumatic injury is associated with increased concentrations of cell-free DNA (cfDNA) in the circulation, which contribute to post-injury complications. The endonuclease deoxyribonuclease 1 (DNase-1) is responsible for removing 90% of circ
Autor:
Robert J. Dinsdale, Paul Harrison, Rury R. Holman, M. Angelyn Bethel, Irene Kennedy, Ruth L. Coleman
Publikováno v:
Platelets. 30:521-529
The antiplatelet efficacy of aspirin (ASA) is reduced in type 2 diabetes (T2D). As the best ex vivo method of measuring ASA efficacy remains uncertain, we compared nine platelet function tests to assess responsiveness to three ASA dosing regimens in
Autor:
Jon Hazeldine, K Al Tarrah, Sarah Watts, T Woolley, Robert J. Dinsdale, Paul Harrison, Peter Hampson, Emrys Kirkman, Mark J. Midwinter, Mark P. Foster, J J Dalle Lucca, Amarpreet Devi, Amy Bamford, Janet M. Lord, Naiem Moiemen, Jon Bishop, Christos Ermogenous
Publikováno v:
The British Journal of Surgery
Background Circulating cell‐free DNA (cfDNA) is not found in healthy subjects, but is readily detected after thermal injury and may contribute to the risk of multiple organ failure. The hypothesis was that a postburn reduction in DNase protein/enzy
Autor:
Emma Toman, Robert J. Dinsdale, Janet M. Lord, Nicholas Crombie, Peter Hampson, David N Naumann, Antonio Belli, Paul Harrison, Jonathan R B Bishop, Zhangjie Su, Jon Hazeldine, David Davies, Niharika A. Duggal
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 14, Iss 7, p e1002338 (2017)
PLoS Medicine, Vol 14, Iss 7, p e1002338 (2017)
Background Almost all studies that have investigated the immune response to trauma have analysed blood samples acquired post-hospital admission. Thus, we know little of the immune status of patients in the immediate postinjury phase and how this migh
Autor:
Christopher M. Wearn, Amy Bamford, Peter Hampson, Chris Watson, Amarpreet Devi, Jon Bishop, Janet M. Lord, Sumiya Ahmed, Jon Hazeldine, Robert J. Dinsdale, Paul Harrison, Naiem Moiemen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
The mortality caused by sepsis is high following thermal injury. Diagnosis is difficult due to the ongoing systemic inflammatory response. Previous studies suggest that cellular parameters may show promise as diagnostic markers of sepsis. The aim of
Autor:
Peter Hampson, Janet M. Lord, Paul Harrison, Amy Bamford, Robert J. Dinsdale, Christopher M. Wearn, Naiem Moiemen, Jonathan R B Bishop, Jon Hazeldine
Publikováno v:
Annals of surgery. 265(6)
The aim of this study was to measure neutrophil function longitudinally following burn injury and to examine the relationship between neutrophil dysfunction and sepsis.Sepsis prevalence and its associated mortality is high following burn injury, and