Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Robert J. DeVita"'
Autor:
Mehdi Yeganeh, Christiane Auray‐Blais, Bruno Maranda, Amanda Sabovic, Robert J. DeVita, Michael B. Lazarus, Sander M. Houten
Publikováno v:
JIMD Reports, Vol 64, Iss 6, Pp 440-445 (2023)
Abstract Hyperlysinemia is a rare autosomal recessive deficiency of 2‐aminoadipic semialdehyde synthase (AASS) affecting the initial step in lysine degradation. It is thought to be a benign biochemical abnormality, but reports on cases remain scarc
Externí odkaz:
https://doaj.org/article/103b38baeae4401682c5bdb0acf2a50e
Autor:
João Leandro, Susmita Khamrui, Chalada Suebsuwong, Peng-Jen Chen, Cody Secor, Tetyana Dodatko, Chunli Yu, Roberto Sanchez, Robert J. DeVita, Sander M. Houten, Michael B. Lazarus
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyses the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both lysine-2-oxoglutarate reductase (LOR) and
Externí odkaz:
https://doaj.org/article/5d1f92da3b604957856043910867cf16
Autor:
Peng Wang, Esra Karakose, Lauryn Choleva, Kunal Kumar, Robert J. DeVita, Adolfo Garcia-Ocaña, Andrew F. Stewart
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a major contributor to all common forms of diabetes. This is the underlying premise for attempts to replace beta cells in people with diabetes by pancreas tr
Externí odkaz:
https://doaj.org/article/afbe04c366a34476897b46b01b7cd797
Autor:
Kunal Kumar, Peng Wang, Ethan A. Swartz, Susmita Khamrui, Cody Secor, Michael B. Lazarus, Roberto Sanchez, Andrew F. Stewart, Robert J. DeVita
Publikováno v:
Molecules, Vol 25, Iss 8, p 1983 (2020)
Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-ce
Externí odkaz:
https://doaj.org/article/c564a90b2224461da09b8c606d089956
Autor:
David G. McLaren, Timothy He, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, Karen Gagen, Gowri Bhat, Kithsiri Herath, Paul L. Miller, Sloan Stribling, Andrew Taggart, Jason Imbriglio, Jinqi Liu, Dunlu Chen, Shirly Pinto, James M. Balkovec, Robert J. DeVita, Donald J. Marsh, Jose M. Castro-Perez, Alison Strack, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1150-1161 (2011)
The use of stable isotopically labeled substrates and analysis by mass spectrometry have provided substantial insight into rates of synthesis, disposition, and utilization of lipids in vivo. The information to be gained from such studies is of partic
Externí odkaz:
https://doaj.org/article/d66b12300bbf4a1f976747589c656716
Autor:
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro
Toxicity of accumulating substrates is a significant problem in several disorders of valine and isoleucine degradation notably short-chain enoyl-CoA hydratase (ECHS1 or crotonase) deficiency, 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency, prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c7ef83a0ddb32aed7b9feba155142
https://doi.org/10.1101/2022.11.22.517273
https://doi.org/10.1101/2022.11.22.517273
Autor:
null João Leandro, null Susmita Khamrui, null Chalada Suebsuwong, null Peng-Jen Chen, null Cody Secor, null Tetyana Dodatko, null Chunli Yu, null Roberto Sanchez, null Robert J. DeVita, null Sander M. Houten, null Michael B. Lazarus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2821e2ece457ef1b68e245110f6536c7
https://doi.org/10.1098/rsob.220179/v3/response1
https://doi.org/10.1098/rsob.220179/v3/response1
Autor:
KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Diabetes results from diminished functional β-cell mass. Small molecule inhibitors of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) markedly increase human β-cell replication in vitro and in vivo. Furthermore, combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0255f87330b1a87dd21556d1ef03f950
https://doi.org/10.2337/db22-822-p
https://doi.org/10.2337/db22-822-p
Autor:
CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
GLP1R agonists such as Exendin-4 (E) together with DYRK1A inhibitors such as Harmine (H) significantly increase human β-cell replication in vitro and in vivo. Importantly, 3-month treatment with H+E combination markedly increases human beta cell mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3409566a6a7e67f5f616972bc15dd62
https://doi.org/10.2337/db22-14-or
https://doi.org/10.2337/db22-14-or
Autor:
GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) results from loss of both immune tolerance and functional β-cells. Administration of harmine (H) plus exendin-4 (E) markedly induces human β-cell expansion. Anti-CD3 antibody treatment reduces C-peptide loss in T1D patients. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c65519c2fa9328c0b26cf64d1e5e271
https://doi.org/10.2337/db22-10-or
https://doi.org/10.2337/db22-10-or