Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert J. Crisp"'
Autor:
Ricardo Henao, Emily R Ko, Bradly P. Nicholson, Emily Lydon, Charles B. Cairns, Andrew Hemmert, Stephen F. Kingsmore, Vance G. Fowler, Jeff Nawrocki, Emanuel P. Rivers, Elizabeth Petzold, Seth W. Glickman, Raymond J. Langley, Micah T. McClain, Mert Aydin, Christopher W. Woods, Robert J Crisp, Anja Kathrin Jaehne, Geoffrey S. Ginsburg, Ephraim L. Tsalik, Montgomery Jesse Linton, Thomas W. Burke, Eugenia Quackenbush
Publikováno v:
Crit Care Med
OBJECTIVES Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and validate a first-in-class host respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259023c403d76863a1585b9d613cc77b
https://europepmc.org/articles/PMC8448917/
https://europepmc.org/articles/PMC8448917/
Autor:
Ephraim L. Tsalik, Jay Jones, Thomas W. Burke, Geoffrey S. Ginsburg, Charles Bullard, Mert Aydin, Robert J Crisp, Maxcén Deneris, Micah T. McClain, Ricardo Henao, Jeff Nawrocki, Christopher W. Woods, Andrew Hemmert, Montgomery Jesse Linton, Craig Gritzen
Publikováno v:
Open Forum Infectious Diseases
Background The inability to reliably discriminate bacterial, viral, and non-infectious illness has led to an epidemic of antibiotic overuse and rising rates of antimicrobial resistance. Host gene expression provides a powerful approach to distinguish
Publikováno v:
Journal of Biological Chemistry. 279:29513-29518
Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the iron regulon, including the high affinity cell-surface transport system encoded by FET3 and FTR1. Here we demonstrate that transcription of these genes does not r
Autor:
Annette Pollington, Shulamit Jaron, Charles A. Galea, Robert J. Crisp, Yuko Yamaguchi-Iwai, Jerry Kaplan
Publikováno v:
Journal of Biological Chemistry. 278:45499-45506
Yeast are capable of modifying their metabolism in response to environmental changes. We investigated the activity of the oxygen-dependent high-affinity iron uptake system of Saccharomyces cerevisiae under conditions of heme depletion. We found that
Publikováno v:
Journal of Biological Chemistry. 275:19628-19637
We have previously described thrombin (Th)-protease nexin 1 (PN1) inhibitory complex binding to cell surface heparins and subsequent low density lipid receptor-related protein (LRP)-mediated internalization. Our present studies examine the catabolism
Publikováno v:
Journal of Sports Sciences. 17:449-466
Twenty-five volleyball players (14 males, 11 females) were videotaped (60 Hz) performing countermovement vertical jumps with and without an arm swing. Ground reaction force and video-based coordinate data were collected simultaneously. The resultant
Publikováno v:
Journal of Biological Chemistry. 274:275-281
We recently identified a synthetic peptide, Pro47–Ile58, derived from the mature protease nexin 1 (PN1) sequence, that inhibited the low density lipoprotein receptor-related protein (LRP)-mediated internalization of thrombin-PN1 (Th-PN1) complexes.
Publikováno v:
The EMBO journal. 25(3)
In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme. We show that the Aft1p binding region of the FET3 promoter or
Publikováno v:
The Journal of biological chemistry. 277(49)
Protease nexin 1 (PN1) in solution forms inhibitory complexes with thrombin or urokinase, which have opposing effects on the blood coagulation cascade. An initial report provided data supporting the idea that PN1 target protease specificity is under
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (7):646-651
All eukaryotes require iron although iron is not readily bioavailable. Organisms expend much effort in acquiring iron and in response have evolved multiple mechanisms to acquire iron. Because iron is essential, organisms prioritize the iron use when