Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Robert J. Casson"'
Publikováno v:
Neurology Perspectives, Vol 3, Iss 1, Pp 100115- (2023)
Externí odkaz:
https://doaj.org/article/36b473aac11944938b3841f4333802b6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Retinal detachment is a sight-threatening disorder, which occurs when the photoreceptors are separated from their vascular supply. The aim of the present study was to shed light on photoreceptor energy metabolism during experimental detachment in rat
Externí odkaz:
https://doaj.org/article/11282eb7a4ec43578efa43f5b70f4ab7
Autor:
Sean Mullany, MD, Henry Marshall, MD, Santiago Diaz-Torres, Ella C. Berry, MChD, Joshua M. Schmidt, PhD, Daniel Thomson, PhD, Ayub Qassim, MBBS, PhD, Minh-Son To, MD, PhD, David Dimasi, PhD, Abraham Kuot, PhD, Lachlan S.W. Knight, Georgina Hollitt, MBBS, Antonia Kolovos, MD, Angela Schulz, PhD, Stewart Lake, MBChB, Richard A. Mills, MBBS, PhD, Ashish Agar, MBBS, PhD, Anna Galanopoulos, MBBS, John Landers, MBBS, PhD, Paul Mitchell, MBBS, PhD, Paul R. Healey, MBBS, PhD, Stuart L. Graham, MBBS, PhD, Alex W. Hewitt, MBBS, PhD, Emmanuelle Souzeau, PhD, Mark M. Hassall, MBBS, DPhil, Sonja Klebe, MBBS, PhD, Stuart MacGregor, PhD, Puya Gharahkhani, PhD, Robert J. Casson, MBBS, DPhil, Owen M. Siggs, MD, DPhil, Jamie E. Craig, MBBS, DPhil
Publikováno v:
Ophthalmology Science, Vol 2, Iss 2, Pp 100159- (2022)
Purpose: To investigate the association between the apolipoprotein E (APOE) E4 dementia-risk allele and prospective longitudinal retinal thinning in a cohort study of suspect and early manifest glaucoma. Design: Retrospective analysis of prospective
Externí odkaz:
https://doaj.org/article/faa3c6b4d45c4abdab7b2a769b6e35ab
Autor:
Henry Marshall, MBBS, Sean Mullany, MD, Xikun Han, PhD, Ella C. Berry, MChD, Mark M. Hassall, DPhil, Ayub Qassim, PhD, Thi Nguyen, BMSc(Optom), Georgina L. Hollitt, MBBS, Lachlan S.W. Knight, MOrth, Bronwyn Ridge, BA, Joshua Schmidt, PhD, Caroline Crowley, BDS, Angela Schulz, PhD, Richard A. Mills, PhD, Ashish Agar, PhD, Anna Galanopoulos, MBBS, John Landers, PhD, Paul R. Healey, PhD, Stuart L. Graham, PhD, Alex W. Hewitt, PhD, Robert J. Casson, DPhil, Stuart MacGregor, PhD, Owen M. Siggs, DPhil, Jamie E. Craig, DPhil
Publikováno v:
Ophthalmology Science, Vol 2, Iss 1, Pp 100108- (2022)
Purpose: To evaluate the association between genetic risk for cardiovascular disease and retinal thinning in early glaucoma. Design: Prospective, observational genetic association study Participants: Multicohort study combining a cohort of patients w
Externí odkaz:
https://doaj.org/article/d54cbf6a31aa47349098337e5e924075
Autor:
Helen Beard, Glyn Chidlow, Daniel Neumann, Nazzmer Nazri, Meghan Douglass, Paul J. Trim, Marten F. Snel, Robert J. Casson, Kim M. Hemsley
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Sanfilippo syndrome is an untreatable form of childhood-onset dementia. Whilst several therapeutic strategies are being evaluated in human clinical trials including i.v. delivery of AAV9-based gene therapy, an urgent unmet need is the availa
Externí odkaz:
https://doaj.org/article/0622df76e85343deb9698b08b762440d
Autor:
Robert J. Casson, John P. M. Wood, Jack Ao, Jagjit S. Gilhotra, Shane R. Durkin, James Muecke, WengOnn Chan, Glyn Chidlow
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 2, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/f690866a6f014552bf76d90ae8b43538
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we pe
Externí odkaz:
https://doaj.org/article/6b0ea6d24a86451783ab8c4250639f47
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Recent studies suggest cone degeneration in retinitis pigmentosa (RP) may result from intracellular energy depletion. We tested the hypothesis that cones die when depleted of energy by examining the effect of two bioenergetic, nutraceutical agents on
Externí odkaz:
https://doaj.org/article/d7edd97d33294ab88b0673946e6e97bc
Autor:
Thaksaon Kittipassorn, Cameron D. Haydinger, John P.M. Wood, Teresa Mammone, Robert J. Casson, Daniel J. Peet
Publikováno v:
Data in Brief, Vol 23, Iss , Pp - (2019)
Müller cells (MCs), the major type of glial cell of the vertebrate retina, have a vital role in retinal physiology and pathology. They provide structural and functional support for retinal neurons, including photoreceptors, and are implicated in var
Externí odkaz:
https://doaj.org/article/cfdb40163b394071840d88b62e07c513
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The vascular hypothesis of glaucoma proposes that retinal ganglion cell axons traversing the optic nerve head (ONH) undergo oxygen and nutrient insufficiency as a result of compromised local blood flow, ultimately leading to their degeneration. To da
Externí odkaz:
https://doaj.org/article/d371aa1df45d4112bb43580a6e4c777c