Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Robert J. Cassell"'
Autor:
Anna M. Gutridge, Soumen Chakraborty, Balazs R. Varga, Elizabeth S. Rhoda, Alexander R. French, Arryn T. Blaine, Quinten H. Royer, Haoyue Cui, Jinling Yuan, Robert J. Cassell, Márk Szabó, Susruta Majumdar, Richard M. van Rijn
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background and Purpose:Mitragyna speciosa extract and kratom alkaloids decrease alcohol consumption in mice at least in part through actions at the δ-opioid receptor (δOR). However, the most potent opioidergic kratom alkaloid, 7-hydroxymitragynine,
Externí odkaz:
https://doaj.org/article/f8fafb8540364aecb9a53a3c306b49b7
Autor:
Yazan J. Meqbil, Hongyu Su, Robert J. Cassell, Kendall L. Mores, Anna M. Gutridge, Benjamin R. Cummins, Lan Chen, Richard M. van Rijn
Publikováno v:
Molecules, Vol 26, Iss 23, p 7236 (2021)
The δ-opioid receptor (δOR) holds great potential as a therapeutic target. Yet, clinical drug development, which has focused on δOR agonists that mimic the potent and selective tool compound SNC80 have largely failed. It has increasingly become ap
Externí odkaz:
https://doaj.org/article/c0f18744066941139e4bde05a78af626
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not,
Externí odkaz:
https://doaj.org/article/3dde103f05cd4c3d9c9964c97367eed2
Autor:
Anna M. Gutridge, Gavril W. Pasternak, Kendall L. Mores, Rajendra Uprety, Robert J. Cassell, Mee Jung Ko, Susruta Majumdar, Meridith T. Robins, Richard M. van Rijn
Publikováno v:
British Journal of Pharmacology
Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self‐medication of chronic pain and to reduce illicit and prescript
Autor:
Ryan A. Altman, Yazan J. Meqbil, Benjamin R. Cummins, Robert J. Cassell, Krishna K. Sharma, David K. Johnson, Kendall L. Mores, Hongyu Su, Richard M. van Rijn, Arryn T. Blaine
Publikováno v:
RSC Med Chem
μ-Opioid receptor agonists provide potent and effective acute analgesia; however, their therapeutic window narrows considerably upon repeated administration, such as required for treating chronic pain. In contrast, bifunctional μ/δ opioid agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a120be4c104a9de5950af71268ac103
https://europepmc.org/articles/PMC8597420/
https://europepmc.org/articles/PMC8597420/
Autor:
Susruta Majumdar, Elizabeth S Rhoda, Balázs Varga, Haoyue Cui, Quinten H Royer, Soumen Chakraborty, Anna M. Gutridge, Robert J. Cassell, Richard M. van Rijn
Publikováno v:
The FASEB Journal. 35
Autor:
Anna M. Gutridge, Yazan J. Meqbil, Hongyu Su, Lan Chen, Robert J. Cassell, Benjamin R. Cummins, Richard M. van Rijn
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Neuropharmacology
G protein-coupled receptors (GPCR) have a long history of being considered a prime target for drug development to treat a plethora of diseases and disorders. In fact in 1827, the first approved therapeutic in the United States was morphine, a drug th
Autor:
Robert J, Cassell, Krishna K, Sharma, Hongyu, Su, Benjamin R, Cummins, Haoyue, Cui, Kendall L, Mores, Arryn T, Blaine, Ryan A, Altman, Richard M, van Rijn
Publikováno v:
Molecules
As tool compounds to study cardiac ischemia, the endogenous δ-opioid receptors (δOR) agonist Leu5-enkephalin and the more metabolically stable synthetic peptide (d-Ala2, d-Leu5)-enkephalin are frequently employed. However, both peptides have simila
Autor:
Casey J. Krusemark, Robert J. Cassell, Richard M. van Rijn, Emily C. Dykhuizen, Saeed S. Akhand, Bo Cai, Michael K. Wendt, Dongwook Kim, Yixing Sun, Aktan Alpsoy
Publikováno v:
Journal of the American Chemical Society. 141(43)
We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach relies on generation of a covalent linkage of the DNA to protein targets by affinity labeling. T