Bifunctional crosslinking ligands for transthyretin

Autor: P. Patrizia Mangione, Stéphanie Deroo, Stephan Ellmerich, Vittorio Bellotti, Simon Kolstoe, Stephen P. Wood, Carol V. Robinson, Martin D. Smith, Glenys A. Tennent, Robert J. Broadbridge, Claire E. Council, Joanne R. Thurston, Victoria A. Steadman, Antonio K. Vong, Christopher J. Swain, Mark B. Pepys, Graham W. Taylor

Publikováno v: Open Biology, Vol 5, Iss 9 (2015)

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease.

Externí odkaz: https://doaj.org/article/92a745814544494abf587c612d2605eb

Bifunctional crosslinking ligands for transthyretin

Autor: Stéphanie Deroo, Graham W. Taylor, Christopher J. Swain, Simon Kolstoe, Martin D. Smith, Palma Mangione, Antonio K. Vong, Vittorio Bellotti, Stephan Ellmerich, Carol V. Robinson, Robert J. Broadbridge, Mark B. Pepys, Glenys A. Tennent, Victoria A. Steadman, Joanne R. Thurston, Steve P. Wood

Publikováno v: Mangione, P P, Deroo, S, Ellmerich, S, Bellotti, V, Kolstoe, S, Wood, S P, Robinson, C V, Smith, M D, Tennent, G A, Broadbridge, R J, Council, C E, Thurston, J R, Steadman, V A, Vong, A K, Swain, C J, Pepys, M B & Taylor, G W 2015, ' Bifunctional crosslinking ligands for transthyretin ', Open Biology, vol. 5, no. 9 . https://doi.org/10.1098/rsob.150105
Open biology, 5 (9
Open Biology
Open Biology, Vol 5, Iss 9 (2015)

Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035d44cdef6210ce634969e39aef832
https://researchportal.port.ac.uk/ws/files/2995143/Simon_K.pdf

First efficient synthesis of α-MAPI

Autor: Robert J. Broadbridge, Muhammad Akhtar

Publikováno v: Chemical Communications. :1449-1450

α-MAPI 1 and its analogues have been synthesised using tri-tert- butoxysilyl protected amino acids in conjunction with a solid-phase N→C assembly; the terminal aldehyde group of the peptide is generated from a C-modified amino acid containing a ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3195e47c36953b0f7d187928d2270df5
https://doi.org/10.1039/a802380h