Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert J. Bjercke"'
Autor:
Jennifer S. Holifield, Robert J. Tomanek, Tommy A. Brock, Alexander Sandra, Robert J. Bjercke, Wei Zheng
Publikováno v:
Circulation Research. 88:1135-1141
Abstract —The roles of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF [FGF-2]) in early postnatal regulation of coronary angiogenesis were investigated by administering neutralizing antibodies to these growth fac
Autor:
Lydia Sturgis, Ronald G. Tilton, Joe Haidacher, Michael T. Crow, Chen Hsiung Yeh, Ondrej Juhasz, Sidney J. Sherwood, Larry Denner, Xue Nong Zhang, Robert J. Bjercke
Publikováno v:
Diabetes. 50:1495-1504
Advanced glycation end product (AGE) activation of the signal-transducing receptor for AGE (RAGE) has been linked to a proinflammatory phenotypic change within cells. However, the precise intracellular signaling pathways involved have not been elucid
Publikováno v:
Circulation Research. 85:192-198
Abstract —A marked coronary angiogenesis is known to occur with chronic bradycardia. We tested the hypothesis that vascular endothelial growth factor (VEGF), an endothelial cell mitogen and a major regulator of angiogenesis, is upregulated in respo
Publikováno v:
American Journal of Physiology-Cell Physiology. 276:C176-C181
We have prepared a polyclonal mouse antibody directed against the first three immunoglobulin-like domains of the kinase insert domain-containing receptor (KDR) tyrosine kinase. It possesses the ability to inhibit binding of the 165-amino acid splice
Autor:
Ajay A. Rege, Tommy A. Brock, David A. Erichsen, Rick T. Owens, Clifford Stephan, Robert J. Bjercke
Publikováno v:
Growth Factors. 16:161-169
Fibroblast growth factor 2 (FGF-2) can function as a potent mitogen, as well as a survival factor for a variety of mammalian cell types. The biological effects of FGF-2 are mediated by its interaction with two types of cellular binding sites: (1) hig
Autor:
Zhiqiang Chen, Robert J. Bjercke, Mohammed Ahmed, Xin Hu, Richard A. F. Dixon, Salman Akhtar, Fred J. Clubb, Ober Jc, Janice McNatt, Edward T. H. Yeh, James T. Willerson, Pierre Zoldhelyi, Pamela Beck
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 279(6)
We tested the hypothesis that selectin inhibition with blocking antibodies or a small-molecular-weight inhibitor of L-, P-, and E-selectin, methoxybenzoylpropionic acid (MBPA), prevents thrombus formation in a canine coronary Folts' model. Cyclic flo
Autor:
Timothy P. Kogan, Scott Ian L, Ashfaq Ahmed, Robert J. Bjercke, Xiaofeng Hu, Edward T.H. Yeh, Richard A. F. Dixon, Pamela J. Beck, B. Mitch Revelle, Yelena Botvinnikova, Isabel T. Lauredo, Juan R. Sabater, William M. Abraham
Publikováno v:
American journal of respiratory and critical care medicine. 159(4 Pt 1)
Antigen challenge can elicit an allergic inflammatory response in the airways that involves eosinophils, basophils, and neutrophils and that is expressed physiologically as a late airway response (LAR) and airway hyperresponsiveness (AHR). Although p
Publikováno v:
Circulation research. 84(3)
Abstract —Vascular structures adapt to changes in blood flow by adjusting their diameter accordingly. The factors mediating this process are only beginning to be identified. We have recently established a mouse model of arterial remodeling in which
Autor:
Wanda S. LeJeune, T P Kogan, David A. Erichsen, R J Biediger, Ronald G. Tilton, Joseph R. Williamson, Clifford Stephan, Ajay A. Rege, Kathy Chang, Tommy A. Brock, Robert J. Bjercke
Publikováno v:
Diabetes. 47(11)
Vascular hyperpermeability and excessive neovascularization are hallmarks of early and late vascular endothelial cell dysfunction induced by diabetes. Vascular endothelial growth factor (VEGF) appears to be an important mediator for these early and l
Autor:
Ronald G. Tilton, Joseph R. Williamson, Robert J. Bjercke, Tommy A. Brock, Yasuo Ido, Takahiko Kawamura, Katherine Chang, Clifford Stephan
Publikováno v:
The Journal of clinical investigation. 99(9)
The purpose of these experiments was to investigate a potential role for vascular endothelial growth factor (VEGF) in mediating vascular dysfunction induced by increased glucose flux via the sorbitol pathway. Skin chambers were mounted on the backs o