Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Robert J. Bauer"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1452-1465 (2021)
Abstract This NONMEM tutorial shows how to evaluate and optimize clinical trial designs, using algorithms developed in design software, such as PopED and PFIM 4.0. Parameter precision and model parameter estimability is obtained by assessing the Fish
Externí odkaz:
https://doaj.org/article/a49bb5cc3d384545ab719dfcdf26765d
Autor:
Robert J. Bauer
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 8, Pp 525-537 (2019)
In this tutorial, the various components of NONMEM will be described, and the basic steps of setting up NONMEM control stream files and data files will be demonstrated. Some basic concepts of nonlinear mixed effects modeling will be discussed, along
Externí odkaz:
https://doaj.org/article/dd4b2eff8c26449a99bdfdefe3bbe77b
Autor:
Robert J. Bauer
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 8, Pp 538-556 (2019)
In this second tutorial on NONMEM, the examples of typical pharmacokinetic/pharmacodynamic modeling problems that occur in the pharmaceutical field will be presented, which the reader can use as a template for his or her own modeling endeavors. Each
Externí odkaz:
https://doaj.org/article/254f76bae2974fe499487a8c3a3c3e18
Autor:
W. Steve Ammons, Robert J. Bauer, Arnold H. Horwitz, Zhi J. Chen, Eddie Bautista, Harry H. Ruan, Marina Abramova, Kristen R. Scott, Russell L. Dedrick
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 2, Pp 146-154 (2003)
ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM ), was evaluated for its in vitro and in vivo activity. The dissociation constant of ING-1(heMAb) for binding to Ep-CAM on HT-29 human colon tumor ce
Externí odkaz:
https://doaj.org/article/b4ec14f2d88f4787824412af41c6a203
Autor:
Richard J, Caselli, Yinghua, Chen, Kewei, Chen, Robert J, Bauer, Dona E C, Locke, Bryan K, Woodruff
Publikováno v:
J Alzheimers Dis
Background: Older age is a major risk factor for severe COVID-19 disease which has been associated with a variety of neurologic complications, both acutely and chronically. Objective: We sought to determine whether milder COVID-19 disease in older vu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b13f246a96a070d74efb7a2b4d93a
https://doi.org/10.3233/jad-220435
https://doi.org/10.3233/jad-220435
Autor:
Freya Bachmann, Gilbert Koch, Robert J. Bauer, Britta Steffens, Gabor Szinnai, Marc Pfister, Johannes Schropp
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 50:173-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::361f468cdc9ed5bf2a340536c4313089
https://doi.org/10.1007/s10928-022-09840-w
https://doi.org/10.1007/s10928-022-09840-w
Autor:
Zhongjing Ren, Ming Lu, Yang Xu, Sundeep Mangla, Xiaoyu Su, Robert J. Bauer, Yong Shi, Chang-Yong Nam, Fernando Camino, Jianping Yuan
Publikováno v:
Microsystem Technologies. 27:3339-3347
This paper presents current divisions and distributed Joule heating of two-dimensional (2D) grid microstructures. The current divisions on 2 × 2, 4 × 4, and n × n grid microstructures made of the same conductive beams are analyzed theoretically, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf075ae4651efc264624794335d4281
https://doi.org/10.1007/s00542-020-05103-1
https://doi.org/10.1007/s00542-020-05103-1
Autor:
Yang Xu, Zhongjing Ren, Sundeep Mangla, Jianping Yuan, Robert J. Bauer, Yong Shi, Ming Lu, Xiaoyu Su
Publikováno v:
Microsystem Technologies. 27:3325-3332
This paper presents a fabrication and characterization of multilayered microstructures with shape memory effects enabling large vertical deployment under electro-thermal actuation. Our previous research demonstrated vertical deployment of such micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b031670c0d21e5415c9fcbfb5126c4f3
https://doi.org/10.1007/s00542-020-05101-3
https://doi.org/10.1007/s00542-020-05101-3
Publikováno v:
The AAPS Journal
Parameter estimation of a nonlinear model based on maximizing the likelihood using gradient-based numerical optimization methods can often fail due to premature termination of the optimization algorithm. One reason for such failure is that these nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a130ea732ca838ec76ac7f40178378
https://doi.org/10.1208/s12248-020-00471-y
https://doi.org/10.1208/s12248-020-00471-y
Publikováno v:
Nucleic Acids Research
The ability of the replisome to seamlessly coordinate both high fidelity and translesion DNA synthesis requires a means to regulate recruitment and binding of enzymes from solution. Co-occupancy of multiple DNA polymerases within the replisome has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60051a779c6e43890649cf787c2b52ec
http://europepmc.org/articles/PMC5737361
http://europepmc.org/articles/PMC5737361