Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Robert J. Barr"'
Autor:
Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, Roy Oelen, Lude Franke, Cisca Wijmenga, Robert J. Barrett, Iris H. Jonkers, Sebo Withoff
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114247- (2024)
Summary: Human induced pluripotent stem cell (hiPSC)-derived intestinal organoids are valuable tools for researching developmental biology and personalized therapies, but their closed topology and relative immature state limit applications. Here, we
Externí odkaz:
https://doaj.org/article/cd45fee274a64df99505faa880e9eee4
Autor:
Dongling Fei, Weihua Shen, Shripad V. Bhagwat, Mark A. Castanares, Brian E. Mattioni, Sheng-Bin Peng, Cecilia Mur, Lisa Kindler, Almudena Rubio, Alfonso De Dios, Jolie Anne Bastian, Baohui Zhao, Thomas K. Baker, Robert J. Barr, Maria Jose Lallena, Jason Manro, Eunice Yuen, Jeffrey Daniel Cohen
Publikováno v:
Cancer Research. 81:1236-1236
Nearly 70% of newly diagnosed breast cancers are estrogen receptor alpha (ERα) positive, for which endocrine therapy is a primary treatment. However, approximately 40% of those patients on endocrine therapy develop resistance, which includes mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b298f3744554131d5c141f569fd34f35
https://doi.org/10.1158/1538-7445.am2021-1236
https://doi.org/10.1158/1538-7445.am2021-1236
Publikováno v:
Brain Sciences, Vol 14, Iss 9, p 868 (2024)
Detailed studies of the equiprobable auditory Go/NoGo task have allowed for the development of a sequential-processing model of the perceptual and cognitive processes involved. These processes are reflected in various components differentiating the G
Externí odkaz:
https://doaj.org/article/d0c5703638994496850ccd7318333f56
Autor:
Robert J. Barry, Genevieve Z. Steiner-Lim, Adele E. Cave, Frances M. De Blasio, Brett MacDonald
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Although the P300 event-related potential (ERP) is the most likely central measure of Sokolov’s Orienting Reflex (OR), there are few systematic comparisons with the skin conductance response (SCR), the “gold standard” electrodermal OR
Externí odkaz:
https://doaj.org/article/b47d0e2e86d449d68ce8d963c196f43b
Autor:
Matthew W. Carson, Robert J. Barr, Dana Sindelar, Daniel Timothy Kohlman, Bradley Condon, David K. Clawson, A. Pustilnik, M. Joelle Dill, James S. Bean, John G. Luz, Michael J. Coghlan, Milan Maletic
Publikováno v:
Journal of Medicinal Chemistry. 58:6607-6618
To further elucidate the structural activity correlation of glucocorticoid receptor (GR) antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroidal antagonist, compound 8, was determined. This novel indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05523d9b3d43e70486cf70fa19d94a56
https://doi.org/10.1021/acs.jmedchem.5b00736
https://doi.org/10.1021/acs.jmedchem.5b00736
Autor:
Anne B. Need, Jesline T. Alexander-Chacko, Donald R. Gehlert, Dana Sindelar, Janice Shaw, Matthew W. Carson, Robert J. Barr, Michael J. Coghlan, Michelle Morin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:192-201
Weight gain and diabetes have been reported during treatment with atypical antipsychotic drugs (AAPDs). Patients treated with the glucocorticoid receptor antagonist (GRA) and the progesterone receptor antagonist (PRA) mifepristone [estra-4,9-dien-3-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a3bb954856a4db9716ecb2d749835
https://doi.org/10.1124/jpet.113.205864
https://doi.org/10.1124/jpet.113.205864
Autor:
Robert M. Amos, Yong Wang, Peter Stanley Borromeo, Robert J. Barr, Timothy Ivo Richardson, Gregory L. Durst, Jeffrey Alan Dodge, Harold E. Osborne, Bryan H. Norman, Scott Alan Jones, Chahrzad Montrose-Rafizadeh, and Amechand Boodhoo, Keyue Chen, Sherry Guo, Charles Willis Lugar, Venkatesh Krishnan
Publikováno v:
Journal of Medicinal Chemistry. 49:6155-6157
Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f98e5d5151dc3683018dd3a7ed409f0
https://doi.org/10.1021/jm060491j
https://doi.org/10.1021/jm060491j
Autor:
Yanfei L. Ma, Lorri L Burris, Henry Uhlman Bryant, Qing Qiang Zeng, Chahrzad Montrose-Rafizadeh, Jianliang Lu, Keith R. Stayrook, Stephen J. Iturria, Masahiko Sato, Allen Schmidt, Robert J. Barr
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25(6)
Vitamin D(3) analogues were shown to be beneficial for osteoporosis and other indications, but their narrow therapeutic window between efficacy and hypercalcemia has limited their clinical utility. A nonsecosteroidal, tissue-selective, orally bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ea9a6a84c318d080080815690aa481
https://pubmed.ncbi.nlm.nih.gov/20200930
https://pubmed.ncbi.nlm.nih.gov/20200930
Autor:
Gagandeep Singh Sachdeva, Joshua Piollo Cabada, Syed Saad Karim, Dmitry Lakvin Kahandawa, Kevin Anil Thomas, Anusha Kumar, Robert J. Barry, Gibran Farook Butt
Publikováno v:
Systematic Reviews, Vol 10, Iss 1, Pp 1-6 (2021)
Abstract Background Corneal transplantation is the most frequently performed transplantation in the UK. Despite this, the therapeutic value of matching human leukocyte antigen (HLA) subtypes for transplanted corneas remains controversial. Ocular immu
Externí odkaz:
https://doaj.org/article/12f74e961a2f40589d53028bd12fe9e6
Autor:
Susie Y. Dai, Thomas P. Burris, Minmin Wang, Jeffrey Alan Dodge, Michael J. Chalmers, John B. Bruning, Yong Wang, Harold E. Osborne, Patrick R. Griffin, Kelli S. Bramlett, Robert J. Barr, Chahrzad Montrose-Rafizadeh
Here, we demonstrate that a single biochemical assay is able to predict the tissue-selective pharmacology of an array of selective estrogen receptor modulators (SERMs). We describe an approach to classify estrogen receptor (ER) modulators based on dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3319146cc616af3226c0ae7396d12925
https://europepmc.org/articles/PMC2438222/
https://europepmc.org/articles/PMC2438222/
