Výsledky vyhledávání - "Robert J. Barbuch"

Reinvestigation of a 5H-dibenzo[d,h][1,3,6]triazonine synthesis

Autor: Norton P. Peet, John C. Huffman, Michael R. Whalon, Shyam Sunder, Robert J. Barbuch, Edward W. Huber

Publikováno v: Journal of Heterocyclic Chemistry. 26:1611-1617

Treatment of 5-chloro-2-aminobenzophenone (1) with o-phenylenediamine, sodium acetate, and acetic acid gave 2-(acetyl)amino-5-chlorobenzophenone (5) rather than N-[(2-amino-5-chlorophenyl)phenylmethylene]-1,2-benzenediamine (3), as reported by Kulkar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9659bf7b758bd41f63fad13f822f0eaf
https://doi.org/10.1002/jhet.5570260619

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Cumulative Mutations Affecting Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae Result in Synthetic Lethality That Is Suppressed by Alterations in Sphingolipid Profiles

Autor: Stephen L. Sturley, Lisa Wilcox, Dina A. Balderes, Robert C. Dickson, M. Shah Alam Bhuiyan, Martin Valachovic, James A. Eckstein, Martin Bard, Robert J. Barbuch, Bart M. Bareither

Publikováno v: Genetics. 173:1893-1908

UPC2 and ECM22 belong to a Zn(2)–Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans. Previous reports suggest that double deletion of these g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc55155bf48c882972e9691e5535db1
https://doi.org/10.1534/genetics.105.053025

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SELECTIVE METABOLISM OF VINCRISTINE IN VITRO BY CYP3A5

Autor: Palaniappan Kulanthaivel, Jamie L. Renbarger, Robert J. Barbuch, William J. Ehlhardt, Jennifer B. Dennison, Stephen D. Hall

Publikováno v: Drug Metabolism and Disposition. 34:1317-1327

Clinical outcomes of vincristine therapy, both neurotoxicity and efficacy, are unpredictable, and the reported pharmacokinetics of vincristine have considerable interindividual variability. In vitro and in vivo data support a dominant role for CYP3A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b03064c60b868f6e57998df3712591f
https://doi.org/10.1124/dmd.106.009902

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Disruption of the Candida albicans CYB5 Gene Results in Increased Azole Sensitivity

Autor: Aaron M. Sturm, James A. Eckstein, Martin Bard, Robert J. Barbuch, Caiqing Mo, N. T. Culbertson, C. A. Pierson, K. M. Rogers, N. D. Lees

Publikováno v: Antimicrobial Agents and Chemotherapy. 48:3425-3435

The fungal end product sterol, ergosterol, and its biosynthetic pathway are the targets of the majority of the antifungal compounds currently in use for human infections and agricultural applications. The primary class of compounds used in human infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d3826364deeb831ce80e58a86d2ac
https://doi.org/10.1128/aac.48.9.3425-3435.2004

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Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans

Autor: P. David Rogers, Russell E. Lewis, James A. Eckstein, Robert J. Barbuch, Nathan P. Wiederhold, Sarah Crisp, Katherine S. Barker, Martin Bard, Bart Bareither

Publikováno v: Journal of Antimicrobial Chemotherapy. 54:376-385

Objectives: The aim of this study was to identify changes in the gene expression profile of Candida albicans associated with the acquisition of experimentally induced resistance to amphotericin B and fluconazole. Methods: C. albicans SC5314 was passe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbadad92adf34330702a470f85d470c
https://doi.org/10.1093/jac/dkh336

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Ergosterol gene expression in wild-type and ergosterol-deficient mutants ofCandidaalbicans

Autor: James A. Eckstein, C. A. Pierson, Robert J. Barbuch, Martin Bard

Publikováno v: Medical Mycology. 42:385-389

The ergosterol pathway is the major target of the azole antifungals. We have developed a panel of five viable ergosterol biosynthetic mutants (erg2, erg3, erg6, erg11 and erg24) and have performed Northern analyses to study transcriptional regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a624d79b55620fe990ee25e82e4cc849
https://doi.org/10.1080/13693780410001712016

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A novel gene conserved from yeast to humans is involved in sterol biosynthesis

Autor: Robert J. Barbuch, Daniel J Gachotte, Christopher J. Roberts, James A. Eckstein, Timothy P. Hughes, Martin Bard

Publikováno v: Journal of Lipid Research, Vol 42, Iss 1, Pp 150-154 (2001)

The ERG28 gene was originally identified by microarray expression profiling as possibly involved in the Saccharomyces cerevisiae sterol pathway. Microarray analyses suggested that the transcription pattern of ERG28 closely followed that of genes invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb3d38a9c0305464fddca8fc0a190e4
http://www.sciencedirect.com/science/article/pii/S0022227520323476

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Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation

Autor: S. E. Sen, M. Krieger, James A. Eckstein, B. D. Ray, Robert J. Barbuch, Daniel J Gachotte, Martin Bard

Publikováno v: Proceedings of the National Academy of Sciences. 96:12655-12660

The last unidentified gene encoding an enzyme involved in ergosterol biosynthesis in Saccharomyces cerevisiae has been cloned. This gene, designated ERG27 , encodes the 3-keto sterol reductase, which, in concert with the C-4 sterol methyloxidase ( ER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca65d3ee59f90c4b589a7b3190cd825a
https://doi.org/10.1073/pnas.96.22.12655

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Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae

Autor: Martin Bard, Matthew A Kennedy, Robert J. Barbuch

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1445:110-122

The ergosterol biosynthetic pathway is a specific branch of the mevalonate pathway. Since the cells requirement for sterols is greater than for isoprenoids, sterol biosynthesis must be regulated independently of isoprenoid biosynthesis. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694f1e664386885eacc3ed9e5ed6932
https://doi.org/10.1016/s0167-4781(99)00035-4

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