Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Robert J. Barbuch"'
Autor:
Denis J. McCann, Maciej J. Zamek-Gliszczynski, Shelby Anderson, Haitao Hu, Kenneth C. Cassidy, Kimberley Jackson, Trent L. Abraham, Nathan A Furr, Robert J. Barbuch, Kay H. Chow, Palaniappan Kulanthaivel, Jeffrey J. Alberts
Publikováno v:
Drug Metabolism and Disposition. 41:714-726
LY2090314 (3-[9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-1H-pyrrole-2,5-dione) is an intravenous glycogen synthase kinase-3 inhibitor in oncology trials. Drug disposition was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3d7c0352b0827cce9d8d21712dceb1
https://doi.org/10.1124/dmd.112.048488
https://doi.org/10.1124/dmd.112.048488
Autor:
Norton P. Peet, John C. Huffman, Michael R. Whalon, Shyam Sunder, Robert J. Barbuch, Edward W. Huber
Publikováno v:
Journal of Heterocyclic Chemistry. 26:1611-1617
Treatment of 5-chloro-2-aminobenzophenone (1) with o-phenylenediamine, sodium acetate, and acetic acid gave 2-(acetyl)amino-5-chlorobenzophenone (5) rather than N-[(2-amino-5-chlorophenyl)phenylmethylene]-1,2-benzenediamine (3), as reported by Kulkar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9659bf7b758bd41f63fad13f822f0eaf
https://doi.org/10.1002/jhet.5570260619
https://doi.org/10.1002/jhet.5570260619
Autor:
Stephen L. Sturley, Lisa Wilcox, Dina A. Balderes, Robert C. Dickson, M. Shah Alam Bhuiyan, Martin Valachovic, James A. Eckstein, Martin Bard, Robert J. Barbuch, Bart M. Bareither
Publikováno v:
Genetics. 173:1893-1908
UPC2 and ECM22 belong to a Zn(2)–Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans. Previous reports suggest that double deletion of these g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc55155bf48c882972e9691e5535db1
https://doi.org/10.1534/genetics.105.053025
https://doi.org/10.1534/genetics.105.053025
Autor:
Palaniappan Kulanthaivel, Jamie L. Renbarger, Robert J. Barbuch, William J. Ehlhardt, Jennifer B. Dennison, Stephen D. Hall
Publikováno v:
Drug Metabolism and Disposition. 34:1317-1327
Clinical outcomes of vincristine therapy, both neurotoxicity and efficacy, are unpredictable, and the reported pharmacokinetics of vincristine have considerable interindividual variability. In vitro and in vivo data support a dominant role for CYP3A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b03064c60b868f6e57998df3712591f
https://doi.org/10.1124/dmd.106.009902
https://doi.org/10.1124/dmd.106.009902
Autor:
Aaron M. Sturm, James A. Eckstein, Martin Bard, Robert J. Barbuch, Caiqing Mo, N. T. Culbertson, C. A. Pierson, K. M. Rogers, N. D. Lees
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:3425-3435
The fungal end product sterol, ergosterol, and its biosynthetic pathway are the targets of the majority of the antifungal compounds currently in use for human infections and agricultural applications. The primary class of compounds used in human infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d3826364deeb831ce80e58a86d2ac
https://doi.org/10.1128/aac.48.9.3425-3435.2004
https://doi.org/10.1128/aac.48.9.3425-3435.2004
Autor:
P. David Rogers, Russell E. Lewis, James A. Eckstein, Robert J. Barbuch, Nathan P. Wiederhold, Sarah Crisp, Katherine S. Barker, Martin Bard, Bart Bareither
Publikováno v:
Journal of Antimicrobial Chemotherapy. 54:376-385
Objectives: The aim of this study was to identify changes in the gene expression profile of Candida albicans associated with the acquisition of experimentally induced resistance to amphotericin B and fluconazole. Methods: C. albicans SC5314 was passe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbadad92adf34330702a470f85d470c
https://doi.org/10.1093/jac/dkh336
https://doi.org/10.1093/jac/dkh336
Publikováno v:
Medical Mycology. 42:385-389
The ergosterol pathway is the major target of the azole antifungals. We have developed a panel of five viable ergosterol biosynthetic mutants (erg2, erg3, erg6, erg11 and erg24) and have performed Northern analyses to study transcriptional regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a624d79b55620fe990ee25e82e4cc849
https://doi.org/10.1080/13693780410001712016
https://doi.org/10.1080/13693780410001712016
Autor:
Robert J. Barbuch, Daniel J Gachotte, Christopher J. Roberts, James A. Eckstein, Timothy P. Hughes, Martin Bard
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 1, Pp 150-154 (2001)
The ERG28 gene was originally identified by microarray expression profiling as possibly involved in the Saccharomyces cerevisiae sterol pathway. Microarray analyses suggested that the transcription pattern of ERG28 closely followed that of genes invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb3d38a9c0305464fddca8fc0a190e4
http://www.sciencedirect.com/science/article/pii/S0022227520323476
http://www.sciencedirect.com/science/article/pii/S0022227520323476
Autor:
S. E. Sen, M. Krieger, James A. Eckstein, B. D. Ray, Robert J. Barbuch, Daniel J Gachotte, Martin Bard
Publikováno v:
Proceedings of the National Academy of Sciences. 96:12655-12660
The last unidentified gene encoding an enzyme involved in ergosterol biosynthesis in Saccharomyces cerevisiae has been cloned. This gene, designated ERG27 , encodes the 3-keto sterol reductase, which, in concert with the C-4 sterol methyloxidase ( ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca65d3ee59f90c4b589a7b3190cd825a
https://doi.org/10.1073/pnas.96.22.12655
https://doi.org/10.1073/pnas.96.22.12655
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1445:110-122
The ergosterol biosynthetic pathway is a specific branch of the mevalonate pathway. Since the cells requirement for sterols is greater than for isoprenoids, sterol biosynthesis must be regulated independently of isoprenoid biosynthesis. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694f1e664386885eacc3ed9e5ed6932
https://doi.org/10.1016/s0167-4781(99)00035-4
https://doi.org/10.1016/s0167-4781(99)00035-4