Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Robert J. Andrew"'
Autor:
Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/ddafc8cc4fce4f2296415a22e72b3b17
Autor:
Pierre De Rossi, Toshihiro Nomura, Robert J. Andrew, Nicolas Y. Masse, Vandana Sampathkumar, Timothy F. Musial, Ari Sudwarts, Aleksandra J. Recupero, Thomas Le Metayer, Mitchell T. Hansen, Ha-Na Shim, Sofia V. Krause, David J. Freedman, Vytas P. Bindokas, Narayanan Kasthuri, Daniel A. Nicholson, Anis Contractor, Gopal Thinakaran
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
Summary: BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in
Externí odkaz:
https://doaj.org/article/3ee20aa26dbb4398a318c588047a8aa8
Autor:
Robert J. Andrew, Haley R. Kowalski, Thomas Guerbette, Steven L. Wagner, Pierre De Rossi, Lisa Laury-Kleintop, Richard C. Rice, Aleksandra J. Recupero, Phuong Nguyen, Sofia V. Krause, Gopal Thinakaran
Publikováno v:
Journal of Biological Chemistry. 294:4477-4487
Alzheimer's disease (AD) is pathologically characterized by the deposition of the β-amyloid (Aβ) peptide in senile plaques in the brain, leading to neuronal dysfunction and eventual decline in cognitive function. Genome-wide association studies hav
Autor:
Vytas P. Bindokas, Valentine de l’Estoile, Gopal Thinakaran, Virginie Buggia-Prevot, Daniel A. Nicholson, David R. Borchelt, Someya Salem, Pierre De Rossi, Guilian Xu, Robert J. Andrew, Tess Valin, Moorthi Ponnusamy, Florin Despa, Timothy F. Musial, Han Ly, Sofia V. Krause, Richard C. Rice
Publikováno v:
Brain Pathology. 29:485-501
Bridging integrator 1 (BIN1) is the most significant late-onset Alzheimer's disease (AD) susceptibility locus identified via genome-wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis an
Autor:
Narayanan Kasthuri, Robert J. Andrew, Thomas Le Metayer, Vytas P. Bindokas, Ha Na Shim, Gopal Thinakaran, Sofia V. Krause, David J. Freedman, Mitchell T. Hansen, Vandana Sampathkumar, Daniel A. Nicholson, Ari Sudwarts, Anis Contractor, Nicolas Y. Masse, Timothy F. Musial, Toshihiro Nomura, Pierre De Rossi, Aleksandra J. Recupero
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
Cell Reports, Vol 30, Iss 10, Pp 3520-3535.e7 (2020)
SUMMARY BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in
Autor:
Toshihiro Nomura, Sofia V. Krause, Vytas P. Bindokas, Mitchell T. Hansen, Narayanan Kasthuri, Vandana Sampathkumar, Nicolase Y. Masse, Robert J. Andrew, Pierre De Rossi, Timothy F. Musial, Anis Contractor, David J. Freedman, Ha-Na Shim, Aleksandra J. Recupero, Daniel A. Nicholson, Ari Sudwarts, Gopal Thinakaran, Thomas Le Metayer
Publikováno v:
SSRN Electronic Journal.
BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer’s disease risk factor. Here, we investigated BIN1 function in the brain using conditional knockout (cKO) models. The loss of neuronal Bin1 expression resulted i
Publikováno v:
Andrew, R J, Kellett, K, Thinakaran, G & Hooper, N 2016, ' A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis ', Journal of Biological Chemistry, vol. 291, pp. 19235-19244 . https://doi.org/10.1074/jbc.R116.746032
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by t
Autor:
Daniel S. Greenspan, Kate Fisher, Sreemoti Banerjee, Catherine B. Lawrence, Carolyn D. Jackson, Katherine A. B. Kellett, Christopher J. Duff, Nobuyo Maeda, Nigel M. Hooper, Robert J. Andrew
Publikováno v:
Scientific Reports
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metallo
Autor:
Pierre, De Rossi, Robert J, Andrew, Timothy F, Musial, Virginie, Buggia-Prevot, Guilian, Xu, Moorthi, Ponnusamy, Han, Ly, Sofia V, Krause, Richard C, Rice, Valentine, de l'Estoile, Tess, Valin, Someya, Salem, Florin, Despa, David R, Borchelt, Vytas P, Bindokas, Daniel A, Nicholson, Gopal, Thinakaran
Publikováno v:
Brain pathology (Zurich, Switzerland). 29(4)
Bridging integrator 1 (BIN1) is the most significant late-onset Alzheimer's disease (AD) susceptibility locus identified via genome-wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis an
Autor:
Sofia V. Krause, Pierre De Rossi, Robert J. Andrew, Tim F. Musial, Virginie Buggia-Prevot, Daniel A. Nicholson, Peter Pytel, Gopal Thinakaran, Richard C. Rice
Publikováno v:
Alzheimer's & Dementia. 14