Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Robert J. Altenbach"'
Autor:
Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128843
Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2a884faa7901f5e486831d30b03cd
https://doi.org/10.1016/j.bmcl.2022.128843
https://doi.org/10.1016/j.bmcl.2022.128843
Autor:
Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377
https://doi.org/10.1021/acsmedchemlett.9b00377
Autor:
Philip R. Kym, Arthur Gomtsyan, Gregory A. Gfesser, Bin Li, Regina M. Reilly, Bruce Clapham, Jerome F. Daanen, Rodger F. Henry, Torben R. Neelands, Pamela S. Puttfarcken, Susan M. Huang, Robert G. Schmidt, Robert J. Altenbach, S.K. Joshi, Huaqing Liu, Marlon D. Cowart, David N. Whittern, Phil B. Cox, Jill-Desiree Brederson, Michael J. Dart, Anurupa Shrestha, Donna Gauvin, Michael E. Kort, Erol K. Bayburt, Ping Song, Steve McGaraughty, Connie R. Faltynek, Heath A. McDonald, Patricia N. Banfor, Diana Schmidt, Eric A. Voight, Mohamad Shebley, Jason A. Segreti
Publikováno v:
Journal of Medicinal Chemistry. 59:4926-4947
Transient receptor potential vanilloid 3 (TRPV3) is a Ca(2+)- and Na(+)-permeable channel with a unique expression pattern. TRPV3 is found in both neuronal and non-neuronal tissues, including dorsal root ganglia, spinal cord, and keratinocytes. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1b773984159dd5e2a719a0398228e6
https://doi.org/10.1021/acs.jmedchem.6b00287
https://doi.org/10.1021/acs.jmedchem.6b00287
Publikováno v:
Synthetic Communications. 34:557-565
5‐Amino‐2H‐pyran‐3(6H)‐one, 1, is a novel intermediate that is useful in the synthesis of pyran containing dihydropyridines. The synthesis and use of 1 will be discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754de90257b87b93cd364d84fe47140f
https://doi.org/10.1081/scc-120027702
https://doi.org/10.1081/scc-120027702
Publikováno v:
Synthetic Communications. 34:567-570
A short and efficient multigram scale synthesis of tetrahydrothiophene‐3‐one‐1,1‐dioxide is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac069a70c90ca8d1023177f509e68720
https://doi.org/10.1081/scc-120027703
https://doi.org/10.1081/scc-120027703
Autor:
Chen Zhao, Robert J. Altenbach, Ramin Faghih, Arthur A. Hancock, Lawrence A. Black, Marlon D. Cowart
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 4:979-992
The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760cea2b83863fca53bb3ec2f6a898a7
https://doi.org/10.2174/1389557043403215
https://doi.org/10.2174/1389557043403215
Autor:
Rodger F. Henry, Steven A. Buckner, Michael E. Brune, Tracy L. Carr, Sweta P. Katwala, Masaki Nakane, Thomas R. Miller, Arthur A. Hancock, Jorge D. Brioni, Anthony V. Daza, Michael Meyer, John C Cain, William A. Carroll, Robert J. Altenbach, Albert Khilevich, Lynne M. Ireland, Fan Yang, Mark W. Holladay, Meena V. Patel, Rohde Jeffrey J, William H. Bunnelle, Chae H Kang, Timothy A. Esbenshade, Donna M. Gauvin, Teodozyj Kolasa, James P. Sullivan, Karin R. Tietje, Jane Kuk, Pramila Bhatia, Alyssa B. O'Neill, Searle Xenia B, Ivan Milicic, Erol K. Bayburt
Publikováno v:
Journal of Medicinal Chemistry. 47:3220-3235
Structure-activity studies were performed on the alpha(1A)-adrenoceptor (AR) selective agonist N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide (4). Compounds were evaluated for binding activity at the alpha(1A), alpha(1b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013ae295bf243228c84c7a005bf8f58
https://doi.org/10.1021/jm030551a
https://doi.org/10.1021/jm030551a
Autor:
Irene Drizin, Jorge D. Brioni, Michael E. Kort, Hao Bai, Michael C. Fitzgerald, Robert J. Gregg, Linda L. King, Robert J. Altenbach, William A. Carroll, Lin Yi, Michael J. Coghlan, Rodger F. Henry, Rui Tang, Anthony V. Daza, Henry Zhang, Murali Gopalakrishnan, Michael E. Brune, Steven A. Buckner, Kristi L. Whiteaker, Thomas A. Fey, Sean C. Turner, Christopher Cassidy, Mark W. Holladay, Yiyuan Chen, Philip R. Kym, Ivan Milicic, James P. Sullivan
Publikováno v:
Journal of Medicinal Chemistry. 47:3163-3179
Structure−activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry, and aromatic substitution were evaluated for KATP activity in guinea pig bladder cells us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48701963d5335233e58180eb726e63f5
https://doi.org/10.1021/jm030356w
https://doi.org/10.1021/jm030356w
Autor:
Michael E. Brune, Teodozyj Kolasa, Michael Meyer, Jorge D. Brioni, James P. Sullivan, William A. Carroll, Robert J. Altenbach, Steven A. Buckner
Publikováno v:
Medicinal Chemistry Research. 13:134-148
SAR studies were conducted around a series of arylalkylimidazoles and arylalkylimidazolines based upon the core structure of A-61603. Changes in ring size, the heterocyclic appendage, aromatic substitution and absolute stereochemistry were examined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b543f291985eb10434aae7d5a43b4f
https://doi.org/10.1007/s00044-004-0020-z
https://doi.org/10.1007/s00044-004-0020-z
Autor:
Ivan Milicic, Char-Chang Shieh, Gary A. Gintant, Rachel Davis-Taber, Murali Gopalakrishnan, John Malysz, Eduardo J. Molinari, Jeffrey S. McDermott, Robert J. Altenbach, Victoria E. Scott, Michael J. Coghlan, Kristi L. Whiteaker, William A. Carroll, Steven A. Buckner, Gary A. Rotert
Publikováno v:
Molecular Pharmacology. 64:143-153
Although ATP-sensitive K+ channels continue to be explored for their therapeutic potential, developments in high-affinity radioligands to investigate native and recombinant KATP channels have been less forthcoming. This study reports the identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df20e2c66c79c49003315198455920d
https://doi.org/10.1124/mol.64.1.143
https://doi.org/10.1124/mol.64.1.143