Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robert J. Barr"'
Autor:
Dongling Fei, Weihua Shen, Shripad V. Bhagwat, Mark A. Castanares, Brian E. Mattioni, Sheng-Bin Peng, Cecilia Mur, Lisa Kindler, Almudena Rubio, Alfonso De Dios, Jolie Anne Bastian, Baohui Zhao, Thomas K. Baker, Robert J. Barr, Maria Jose Lallena, Jason Manro, Eunice Yuen, Jeffrey Daniel Cohen
Publikováno v:
Cancer Research. 81:1236-1236
Nearly 70% of newly diagnosed breast cancers are estrogen receptor alpha (ERα) positive, for which endocrine therapy is a primary treatment. However, approximately 40% of those patients on endocrine therapy develop resistance, which includes mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b298f3744554131d5c141f569fd34f35
https://doi.org/10.1158/1538-7445.am2021-1236
https://doi.org/10.1158/1538-7445.am2021-1236
Autor:
Matthew W. Carson, Robert J. Barr, Dana Sindelar, Daniel Timothy Kohlman, Bradley Condon, David K. Clawson, A. Pustilnik, M. Joelle Dill, James S. Bean, John G. Luz, Michael J. Coghlan, Milan Maletic
Publikováno v:
Journal of Medicinal Chemistry. 58:6607-6618
To further elucidate the structural activity correlation of glucocorticoid receptor (GR) antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroidal antagonist, compound 8, was determined. This novel indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05523d9b3d43e70486cf70fa19d94a56
https://doi.org/10.1021/acs.jmedchem.5b00736
https://doi.org/10.1021/acs.jmedchem.5b00736
Autor:
Anne B. Need, Jesline T. Alexander-Chacko, Donald R. Gehlert, Dana Sindelar, Janice Shaw, Matthew W. Carson, Robert J. Barr, Michael J. Coghlan, Michelle Morin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:192-201
Weight gain and diabetes have been reported during treatment with atypical antipsychotic drugs (AAPDs). Patients treated with the glucocorticoid receptor antagonist (GRA) and the progesterone receptor antagonist (PRA) mifepristone [estra-4,9-dien-3-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a3bb954856a4db9716ecb2d749835
https://doi.org/10.1124/jpet.113.205864
https://doi.org/10.1124/jpet.113.205864
Autor:
Robert M. Amos, Yong Wang, Peter Stanley Borromeo, Robert J. Barr, Timothy Ivo Richardson, Gregory L. Durst, Jeffrey Alan Dodge, Harold E. Osborne, Bryan H. Norman, Scott Alan Jones, Chahrzad Montrose-Rafizadeh, and Amechand Boodhoo, Keyue Chen, Sherry Guo, Charles Willis Lugar, Venkatesh Krishnan
Publikováno v:
Journal of Medicinal Chemistry. 49:6155-6157
Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f98e5d5151dc3683018dd3a7ed409f0
https://doi.org/10.1021/jm060491j
https://doi.org/10.1021/jm060491j
Autor:
Yanfei L. Ma, Lorri L Burris, Henry Uhlman Bryant, Qing Qiang Zeng, Chahrzad Montrose-Rafizadeh, Jianliang Lu, Keith R. Stayrook, Stephen J. Iturria, Masahiko Sato, Allen Schmidt, Robert J. Barr
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25(6)
Vitamin D(3) analogues were shown to be beneficial for osteoporosis and other indications, but their narrow therapeutic window between efficacy and hypercalcemia has limited their clinical utility. A nonsecosteroidal, tissue-selective, orally bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ea9a6a84c318d080080815690aa481
https://pubmed.ncbi.nlm.nih.gov/20200930
https://pubmed.ncbi.nlm.nih.gov/20200930
Autor:
Susie Y. Dai, Thomas P. Burris, Minmin Wang, Jeffrey Alan Dodge, Michael J. Chalmers, John B. Bruning, Yong Wang, Harold E. Osborne, Patrick R. Griffin, Kelli S. Bramlett, Robert J. Barr, Chahrzad Montrose-Rafizadeh
Here, we demonstrate that a single biochemical assay is able to predict the tissue-selective pharmacology of an array of selective estrogen receptor modulators (SERMs). We describe an approach to classify estrogen receptor (ER) modulators based on dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3319146cc616af3226c0ae7396d12925
https://europepmc.org/articles/PMC2438222/
https://europepmc.org/articles/PMC2438222/
Autor:
Thomas P. Burris, Keith A. Houck, Christopher D. Hepler, Benjamin C. Yaden, Kelli S. Bramlett, Heather A Bullock, Venkatesh Krishnan, Robert J. Barr, Keith R. Stayrook, Rachelle J. Sells Galvin, Richard W. Zink, Chahrzad Montrose, Lorri L Burris, Christine C. Cheng, Wayne P. Bocchinfuso, Harold E. Osborne
Publikováno v:
Molecular pharmacology. 67(3)
Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans, including dyslipidemia, obesity, and inflammation. The activity of GS has been suggested to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa58e5a1cb3b2f8e40e96d27d8425b
https://pubmed.ncbi.nlm.nih.gov/15602004
https://pubmed.ncbi.nlm.nih.gov/15602004
Autor:
Henry Uhlman Bryant, Benjamin C. Yaden, Heather A Bullock, Min Liu, Jeffrey Alan Dodge, Venkatesh Krishnan, Keyue Chen, Robert J. Barr, Chahrzhad Montrose-Rafizadeh
Publikováno v:
Molecular pharmacology. 67(3)
The nongenotropic ligand estren (Science 298:843-846, 2002) was evaluated for its transcriptional activity mediated by the human androgen receptor (AR). Our results show that estren can bind, translocate, transactivate, and regulate two known target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9a41483a3557b744d6911679c6cdab
https://pubmed.ncbi.nlm.nih.gov/15557561
https://pubmed.ncbi.nlm.nih.gov/15557561
Autor:
James S. Bean, Raymond F. Kauffman, Jaipal Singh, Ashraf Saeed, Robert J. Barr, Chahrzad Montrose-Rafizadeh, William R. Bensch, Deepa Rungta, John J. Osborne, Daniel Ray Mayhugh, Naijia Huang, Dale E. Maise, Nathan Yumibe, Xiaodong Wang, Richard Craig Thompson, Samuel J. Dominianni, Debra Luffer-Atlas, Nathan Bryan Mantlo, Richard W. Zink, Yanping Xu
Publikováno v:
Journal of medicinal chemistry. 46(24)
A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13f14dc57aed78bd2aaebf15fbc7db7
https://pubmed.ncbi.nlm.nih.gov/14613314
https://pubmed.ncbi.nlm.nih.gov/14613314
Autor:
Keith A. Houck, Patrick I. Eacho, Michele Dowless, Thomas P. Burris, Chahrzad Montrose, Youyan Zhang, Palaniappan Kulanthaivel, Robert J. Barr, Robert L. Schmidt, Laura F. Michael, Guoqing Cao, Kelli S. Bramlett, Kristen M. Borchert, Thomas P. Beyer, Jeffrey S. Thomas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 307(1)
Natural products have been identified as ligands for a number of members of the nuclear hormone receptor (NHR) superfamily. Often these natural products are used as dietary supplements to treat myriad ailments ranging from perimenopausal hot flashes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd9b022dc7ac383d7423cbb12c03a65
https://pubmed.ncbi.nlm.nih.gov/12893846
https://pubmed.ncbi.nlm.nih.gov/12893846