Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Robert J Sutherland"'
Autor:
Surjeet Singh, Edgar Bermudez-Contreras, Mojtaba Nazari, Robert J Sutherland, Majid H Mohajerani
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220751 (2019)
In the current research on measuring complex behaviours/phenotyping in rodents, most of the experimental design requires the experimenter to remove the animal from its home-cage environment and place it in an unfamiliar apparatus (novel environment).
Externí odkaz:
https://doaj.org/article/fcc7f5240acd44e08a8b3080a79cd65b
Autor:
Robert J. McDonald, Joelle Kopp, Erin L. Zelinski, Robert J. Sutherland, Hugo Lehmann, Fraser Sparks, Nancy S. Hong
Publikováno v:
Journal of Integrative Neuroscience, Vol 23, Iss 11, p 205 (2024)
Background: The goal of these experiments was to determine which learning and memory system(s) were necessary for the retention of visual discriminations and subsequent acquisition of a second problem. The dorsal striatum should be involved in the ac
Externí odkaz:
https://doaj.org/article/6278bb9031b14791bb715a2cb0663fe2
Autor:
Gregory J Christie, Charles M Cook, Brian J Ward, Matthew S Tata, Janice Sutherland, Robert J Sutherland, Deborah M Saucier
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57390 (2013)
This study investigated how both sex and individual differences in a mental rotation test (MRT) influence performance on working memory (WM). To identify the neural substrate supporting these differences, brain electrical activity was measured using
Externí odkaz:
https://doaj.org/article/8f4560588e7e451cad246e2b793c0f3a
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27426 (2011)
Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA is also known to cause intense
Externí odkaz:
https://doaj.org/article/dfbb90b015584d999a395a21462b3a45
Autor:
Jogender Mehla, Scott H. Deibel, Hadil Karem, Nancy S. Hong, Shakhawat R. Hossain, Sean G. Lacoursiere, Robert J. Sutherland, Majid H. Mohajerani, Robert J. McDonald
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Education, occupation, and an active lifestyle, comprising enhanced social, physical, and mental components are associated with improved cognitive functions in aged people and may delay the progression of various neurodegenerative diseases i
Externí odkaz:
https://doaj.org/article/c9a1037be9b04e42a1d7fc80f97853cd
Background. Alzheimer’s disease (AD) is characterized by the prion-like propagation of amyloid-β (Aβ). However, the role of Ab in cognitive impairment is still unclear. Methods. Two-month-old AppNL-G-F were intracerebrally seeded with three confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0479218e3d213b47cf1f3ace0896a17d
https://doi.org/10.21203/rs.3.rs-2231253/v1
https://doi.org/10.21203/rs.3.rs-2231253/v1
Autor:
Surjeet Singh, Sean G. Lacoursiere, Jogender Mehla, Mojtaba Nazari, Robert J. Sutherland, Robert J. McDonald, Majid H. Mohajerani
Alzheimer’s disease (AD) is characterized neuropathologically by amyloid-β (Aβ) plaques and neurofibrillary tangles. Vascular pathology caused by chronic cerebral hypoperfusion (HP) is hypothesised to exacerbate AD pathology and has emerged as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::771421672b384031c35bc7fd81712dbb
https://doi.org/10.1101/2022.10.25.513783
https://doi.org/10.1101/2022.10.25.513783
Autor:
Jogender Mehla, Scott H. Deibel, Hadil Karem, Shakhawat Hossain, Sean G. Lacoursiere, Robert J. Sutherland, Majid H. Mohajerani, Robert J. McDonald
Publikováno v:
Alzheimer's Research & Therapy. 14
Background An active lifestyle is associated with improved cognitive functions in aged people and may prevent or slow down the progression of various neurodegenerative diseases including Alzheimer’s disease (AD). To investigate these protective eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94252d1bc2bed196d139a565c2a8078d
https://doi.org/10.1186/s13195-022-01085-6
https://doi.org/10.1186/s13195-022-01085-6
Autor:
Sean G. Lacoursiere, Brendan B. McAllister, Crystal Hadikin, Wayne W. Tschetter, Hugo Lehmann, Robert J. Sutherland
Damage to the hippocampus produces profound retrograde amnesia, but odour and object discrimination memories can be spared in the retrograde direction following hippocampal damage. Prior lesion studies testing retrograde amnesia for object/odour disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6245f77b8a35fa2f99d2af86501a1e83
https://doi.org/10.1101/2022.09.14.508050
https://doi.org/10.1101/2022.09.14.508050
Publikováno v:
Frontiers in Dementia. 1
Alzheimer's disease (AD) is characterized by the prion-like propagation of amyloid-β (Aβ). However, the role of Aβ in cognitive impairment is still unclear. To determine the causal role of Aβ in AD, we intracerebrally seeded the entorhinal cortex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c129157b5f16ec7c2d8a3bcdf6584387
https://doi.org/10.3389/frdem.2022.941879
https://doi.org/10.3389/frdem.2022.941879