Zobrazeno 1 - 10
of 355
pro vyhledávání: '"Robert J Schwartz"'
Autor:
Keisuke Nimura, Masamichi Yamamoto, Makiko Takeichi, Kotaro Saga, Katsuyoshi Takaoka, Norihiko Kawamura, Hirohisa Nitta, Hiromichi Nagano, Saki Ishino, Tatsuya Tanaka, Robert J Schwartz, Hiroyuki Aburatani, Yasufumi Kaneda
Publikováno v:
eLife, Vol 5 (2016)
Transcription factors organize gene expression profiles by regulating promoter activity. However, the role of transcription factors after transcription initiation is poorly understood. Here, we show that the homeoprotein Nkx2-5 and the 5’-3’ exon
Externí odkaz:
https://doaj.org/article/edbfe0b136dc4e7f952bb9f94f4c0f27
Autor:
Tara L Rasmussen, Yanlin Ma, Chong Yon Park, June Harriss, Stephanie A Pierce, Joseph D Dekker, Nicolas Valenzuela, Deepak Srivastava, Robert J Schwartz, M David Stewart, Haley O Tucker
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121765 (2015)
Smyd1/Bop is an evolutionary conserved histone methyltransferase previously shown by conventional knockout to be critical for embryonic heart development. To further explore the mechanism(s) in a cell autonomous context, we conditionally ablated Smyd
Externí odkaz:
https://doaj.org/article/6474b35f28774de6a4df747fea3aeed0
Autor:
Jun Wang, Yan Bai, Hong Li, Stephanie B Greene, Elzbieta Klysik, Wei Yu, Robert J Schwartz, Trevor J Williams, James F Martin
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003785 (2013)
Among the most common human congenital anomalies, cleft lip and palate (CL/P) affects up to 1 in 700 live births. MicroRNA (miR)s are small, non-coding RNAs that repress gene expression post-transcriptionally. The miR-17-92 cluster encodes six miRs t
Externí odkaz:
https://doaj.org/article/9a295d38ba574972bbee7701823ca1cd
Autor:
Cissy Chenyi Zhou, Jiang Chang, Tiejuan Mi, Shahrzad Abbasi, Dongmin Gu, Le Huang, WenZheng Zhang, Rodney E Kellems, Robert J Schwartz, Yang Xia
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29236 (2012)
Inadequate placental development is associated with a high incidence of early embryonic lethality and serious pregnancy disorders in both humans and mice. However, the lack of well-defined trophoblast-specific gene regulatory elements has hampered in
Externí odkaz:
https://doaj.org/article/3a7710307c9a4757a9a5271a3a2c635c
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31005 (2012)
Ezh2 is a histone trimethyltransferase that silences genes mainly via catalyzing trimethylation of histone 3 lysine 27 (H3K27Me3). The role of Ezh2 as a regulator of gene silencing and cell proliferation in cancer development has been extensively inv
Externí odkaz:
https://doaj.org/article/8cca2fe52b744860b0c756ceb9317144
Autor:
Arfaxad Reyes-Alcaraz, Hanan Qasim, Elizabeth Merlinsky, Glenn Fox, Tasneem Islam, Bryan Medina, Robert J. Schwartz, John W. Craft, Bradley K. McConnell
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 916 (2023)
The COVID-19 pandemic has underscored the urgent need to develop highly potent and safe medications that are complementary to the role of vaccines. Specifically, it has exhibited the need for orally bioavailable broad-spectrum antivirals that are abl
Externí odkaz:
https://doaj.org/article/89b041fb5695417ea1833557b4b88c9e
Autor:
M. David Stewart, Xin Wang, Fan Wang, Yinghong Ren, Raymond Saba, Zhi Tan, Benjamin Soibam, Anam Syed, Rui Liang, Robert J. Schwartz, Xiaopeng Shen, Yu Liu, Yoonjung Park, Bradley K. McConnell, Alex DesJarlais, Jin Yang, Shreesti Shrestha, Xuan Ji, Ashok Kumar, Fang Yu
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 2174-2186 (2021)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle
Background Skeletal muscle atrophy is a debilitating complication of many chronic diseases, disuse conditions, and ageing. Genome‐wide gene expression analyses have identified that elevated levels of microRNAs encoded by the H19X locus are among th
Autor:
Vladimir N. Potaman, Reza Abbasgholizadeh, Ravi K. Birla, Robert J. Schwartz, Stephen Navran, Jose Francisco Islas
Publikováno v:
Cardiovascular Engineering and Technology. 11:205-218
The objective of this study was to bioengineer 3D patches from cardiac myocytes that have been reprogrammed from human adipogenic mesenchymal stem cells (hADMSCs). Human adipogenic mesenchymal stem cells (hADMSCs) were reprogrammed to form cardiac my
Autor:
Preethi H. Gunaratne, Brandon Mistretta, Robert J. Schwartz, Suchi Raghunathan, Bradley K. McConnell, Liheng Shi, Dinakar Iyer, Jose Francisco Islas, Gladys Y.-P. Ko
Publikováno v:
J Mol Cell Cardiol
We used a screening strategy to test for reprogramming factors for the conversion of human cardiac progenitor cells (CPCs) into Pacemaker-like cells. Human transcription factors SHOX2, TBX3, TBX5, TBX18, and the channel protein HCN2, were transiently
Autor:
Neha Tandon, Benjamin Soibam, Mihai Gagea, Yu Liu, Robert J. Schwartz, Abhinav K. Jain, Fan Wang, Kristina Goller
Publikováno v:
EBioMedicine, Vol 50, Iss, Pp 55-66 (2019)
EBioMedicine
EBioMedicine
Background: Mesoderm Posterior 1 (MESP1) belongs to the family of basic helix-loop-helix transcription factors. It is a master regulator of mesendoderm development, leading to formation of organs such as heart and lung. However, its role in adult pat