Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert J Schulingkamp"'
Autor:
Monicah A. Otieno, Peggy Guzzie-Peck, Thomas W. Jones, Robert J Schulingkamp, Sherry J. Morgan, Ray Kemper, Douglas A. Keller, Jessica Couch
Publikováno v:
Toxicologic Pathology. 45:372-380
An Innovation and Quality (IQ) Consortium focus group conducted a cross-company survey to evaluate current practices and perceptions around the use of animal models of disease (AMDs) in nonclinical safety assessment of molecules in clinical developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55e3d71fe05117175c74da158f90bcc
https://doi.org/10.1177/0192623317701004
https://doi.org/10.1177/0192623317701004
Autor:
Sherry J, Morgan, Jessica, Couch, Peggy, Guzzie-Peck, Douglas A, Keller, Ray, Kemper, Monicah A, Otieno, Robert J, Schulingkamp, Thomas W, Jones
Publikováno v:
Toxicologic pathology. 45(3)
An Innovation and Quality (IQ) Consortium focus group conducted a cross-company survey to evaluate current practices and perceptions around the use of animal models of disease (AMDs) in nonclinical safety assessment of molecules in clinical developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb33947cabcec10854013c397ee335c4
https://pubmed.ncbi.nlm.nih.gov/28351296
https://pubmed.ncbi.nlm.nih.gov/28351296
Publikováno v:
Pharmacology. 74:23-30
α1-Adrenoceptor function and density in isolated thoracic aorta were measured during the course of streptozotocin-induced diabetes in rats. Diabetes was induced by a single tail vein injection of streptozotocin (60 mg/kg) and was verified by four me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e288e7c692613b4b2c9565a08cb371
https://doi.org/10.1159/000083211
https://doi.org/10.1159/000083211
Autor:
Lisa M Ciaccia, Robert B. Raffa, Anne Schock Citver, Robert J Schulingkamp, Anastasia M Shields
Publikováno v:
Journal of Clinical Pharmacy and Therapeutics. 27:161-168
Present antipsychotic drugs, whose clinical activity correlates with direct binding to dopamine D2 or other receptors, alleviate some of the symptoms of schizophrenia, but not all and not completely in many patients. In continuation of our overview o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ae6e9f22127e25805811690975ef9c
https://doi.org/10.1046/j.1365-2710.2002.00410.x
https://doi.org/10.1046/j.1365-2710.2002.00410.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:925-929
Ribonucleases (RNases) possess a variety of biological activities and, under certain conditions, are deleterious. Hence, design of selective inhibitors has been suggested as a strategy for treating RNase-related disorders. In the present study, isoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4435add35519cdd8846f5d76c8ba3e75
https://doi.org/10.1124/jpet.301.3.925
https://doi.org/10.1124/jpet.301.3.925
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 45:223-226
Introduction: Dopaminergic ligands, including drugs of abuse, modulate the locomotor activity of planarians and induce characteristic abnormal patterns of motility at high doses. It has been presumed that the effect is related to dopamine receptors b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed7a2c8894d918f5e87d42c9173f85
https://doi.org/10.1016/s1056-8719(01)00152-6
https://doi.org/10.1016/s1056-8719(01)00152-6
Publikováno v:
Pharmacology. 74(1)
alpha(1)-Adrenoceptor function and density in isolated thoracic aorta were measured during the course of streptozotocin-induced diabetes in rats. Diabetes was induced by a single tail vein injection of streptozotocin (60 mg/kg) and was verified by fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a903eed4a4022dd1400c0d06d6289f97
https://pubmed.ncbi.nlm.nih.gov/15640611
https://pubmed.ncbi.nlm.nih.gov/15640611
Publikováno v:
Biochemical pharmacology. 63(11)
Certain ribonucleases (RNases), such as eosinophil-derived neurotoxin, are associated with pathological conditions (e.g. asthma and inflammatory bowel disease) and can even be overtly cyto(neuro)toxic. It has been proposed that small-molecule inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b436ecbb70099e08a979d90305a416a
https://pubmed.ncbi.nlm.nih.gov/12093469
https://pubmed.ncbi.nlm.nih.gov/12093469
Publikováno v:
European Journal of Pharmacology. 406:R11-R12
The dopamine D2 receptor antagonist sulpiride decreases the spontaneous locomotor activity of Planaria in an enantiomeric-selective and dose-dependent manner. We now report that (-)sulpiride (0.1 microM)-induced decrease of planarian locomotor activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24288844deda6f2c25d44edb2f08582a
https://doi.org/10.1016/s0014-2999(00)00730-5
https://doi.org/10.1016/s0014-2999(00)00730-5