Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Robert J Pelham"'
Autor:
Nicholas Barasch, Xue Gong, Kevin A Kwei, Sushama Varma, Jewison Biscocho, Kunbin Qu, Nan Xiao, Joseph S Lipsick, Robert J Pelham, Robert B West, Jonathan R Pollack
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171265 (2017)
Pathogenic gene fusions have been identified in several histologic types of salivary gland neoplasia, but not previously in acinic cell carcinoma (AcCC). To discover novel gene fusions, we performed whole-transcriptome sequencing surveys of three AcC
Externí odkaz:
https://doaj.org/article/614af5fbee1a4ef991eedc4a5ab3af7a
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46518 (2012)
The phosphoinositide 3-kinase (PI3K) signaling pathway is significantly altered in a wide variety of human cancers, driving cancer cell growth and survival. Consequently, a large number of PI3K inhibitors are now in clinical development. To begin to
Externí odkaz:
https://doaj.org/article/e8ea3c3768354bf380015c7b51a6c88a
Autor:
Dominick Sinicropi, Kunbin Qu, Francois Collin, Michael Crager, Mei-Lan Liu, Robert J Pelham, Mylan Pho, Andrew Dei Rossi, Jennie Jeong, Aaron Scott, Ranjana Ambannavar, Christina Zheng, Raul Mena, Jose Esteban, James Stephans, John Morlan, Joffre Baker
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40092 (2012)
RNA biomarkers discovered by RT-PCR-based gene expression profiling of archival formalin-fixed paraffin-embedded (FFPE) tissue form the basis for widely used clinical diagnostic tests; however, RT-PCR is practically constrained in the number of trans
Externí odkaz:
https://doaj.org/article/d36e7cdb6c1d4efc892f4c01917f5194
Autor:
Fortunato Ciardiello, Yung‐Jue Bang, Andrés Cervantes, Mikhail Dvorkin, Charles D. Lopez, Jean‐Philippe Metges, Antonio Sánchez Ruiz, Mariona Calvo, Andrew H. Strickland, George Kannourakis, Kei Muro, Hisato Kawakami, Jia Wei, Christophe Borg, Zhaoyin Zhu, Neal Gupta, Robert J. Pelham, Lin Shen
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13145-13154 (2023)
Abstract Background Poly (ADP‐ribose) polymerase (PARP) inhibitors (PARPi) are approved for the treatment of various solid tumors. In gastric cancer, genes commonly harbor mutations in the homologous recombination DNA repair pathway, potentially in
Externí odkaz:
https://doaj.org/article/4b2f01f4e75d4aedaab63e873f6aa1b0
Autor:
Tim S. Wang, Catherine Lee, Paul Severson, Robert J. Pelham, Richard Williams, Nichol L. G. Miller
Publikováno v:
Cancer Research. 83:4927-4927
Background: MAPK activating mutations are common in melanoma, with 40% of cases attributed to oncogenic BRAF mutations and 20-25% NRAS mutations. Secondary MAPK activation is a known resistance mechanism to approved BRAF inhibitors in BRAFV600 melano
Autor:
Stephanie Kareht, Onur Sakarya, Charles Swanton, Mariam Jamal-Hanjani, Tudor Constantin, Bernhard Zimmermann, Raheleh Salari, Richard Mitter, Robert J. Pelham, Styrmir Sigurjonsson, Eser Kirkizlar, Stuart Horswell, Gareth A. Wilson
Publikováno v:
Annals of Oncology. 27:862-867
The aim of this pilot study was to assess whether both ubiquitous and heterogeneous somatic mutations could be detected in cell-free DNA (cfDNA) from patients with early-stage non-small-cell lung cancer (NSCLC).Three stage I and one stage II primary
Autor:
Jianbo Li, Michael W. Kattan, Diana B. Cherbavaz, Tara Maddala, June M. Chan, Steven Shak, Athanasios C. Tsiatis, Frederick L. Baehner, Imelda Tenggara-Hunter, Eric A. Klein, Mark Lee, Jeffry P. Simko, Sara M. Falzarano, Janet E. Cowan, Dejan Knezevic, Matthew R. Cooperberg, Phillip G. Febbo, Peter R. Carroll, Robert J. Pelham, Cristina Magi-Galluzzi
Publikováno v:
Klein, EA; Cooperberg, MR; Magi-Galluzzi, C; Simko, JP; Falzarano, SM; Maddala, T; et al.(2014). A 17-gene assay to predict prostate cancer aggressiveness in the context of gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. European Urology, 66(3), 550-560. doi: 10.1016/j.eururo.2014.05.004. UCSF: Retrieved from: http://www.escholarship.org/uc/item/71p0s63x
European Urology, vol 66, iss 3
European urology, vol 66, iss 3
Klein, EA; Cooperberg, MR; Magi-Galluzzi, C; Simko, JP; Falzarano, SM; Maddala, T; et al.(2014). A 17-gene Assay to Predict Prostate Cancer Aggressiveness in the Context of Gleason Grade Heterogeneity, Tumor Multifocality, and Biopsy Undersampling. European Urology. doi: 10.1016/j.eururo.2014.05.004. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1p2685jh
European Urology, vol 66, iss 3
European urology, vol 66, iss 3
Klein, EA; Cooperberg, MR; Magi-Galluzzi, C; Simko, JP; Falzarano, SM; Maddala, T; et al.(2014). A 17-gene Assay to Predict Prostate Cancer Aggressiveness in the Context of Gleason Grade Heterogeneity, Tumor Multifocality, and Biopsy Undersampling. European Urology. doi: 10.1016/j.eururo.2014.05.004. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1p2685jh
Background Prostate tumor heterogeneity and biopsy undersampling pose challenges to accurate, individualized risk assessment for men with localized disease. Objective To identify and validate a biopsy-based gene expression signature that predicts cli
Autor:
Francois Collin, Mylan Pho, Kunbin Qu, RR Mena, Ranjana Ambannavar, Robert J. Pelham, MC Liu, Aaron Scott, Joffre B. Baker, J Esteban, J-H Jeong, Dominick Sinicropi, James C. Stephans, John Morlan, Michael Crager
Publikováno v:
Cancer Research. 71:PD03-09
Background: RNA biomarkers discovered by RT-PCR-based gene expression profiling of archival formalin-fixed paraffin-embedded (FFPE) tissue are the basis for very precise and sensitive clinical diagnostic tests, such as the 21 gene Oncotype DX® breas
Autor:
Shibao Feng, Xuguang Hu, Philippe Moreau, Jonathan J Keats, Hang Quach, Meletios A. Dimopoulos, Tibor Kovacsovics, Robert J. Pelham, Albert Oriol, Amy S. Kimball
Publikováno v:
Blood. 130:839-839
Background: In the phase 3 ENDEAVOR trial, treatment with carfilzomib administered at 56 mg/m2 twice weekly in combination with dexamethasone (Kd56) significantly improved progression-free survival (PFS) compared to treatment with bortezomib and dexa
Autor:
David Mu, Linda Rodgers, Scott Powers, David Botstein, Nicholas Navin, Michael Wigler, Ken C. Q. Nguyen, Ira M. Hall, Robert Lucito, Robert J. Pelham, James W. Hicks
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19848-19853
The interactions between cancer cells and the surrounding host stromal tissue play a critical role in tumor progression and metastasis, but the molecular nature of this relationship remains largely uncharacterized. Furthermore, although genetic chang