Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Robert J Lipinski"'
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256299 (2021)
Tamoxifen is an estrogen receptor (ER) ligand with widespread use in clinical and basic research settings. Beyond its application in treating ER-positive cancer, tamoxifen has been co-opted into a powerful approach for temporal-specific genetic alter
Externí odkaz:
https://doaj.org/article/8b17ba8695694a41b57d7cab74fb038c
Autor:
Galen W Heyne, Cal G Melberg, Padydeh Doroodchi, Kia F Parins, Henry W Kietzman, Joshua L Everson, Lydia J Ansen-Wilson, Robert J Lipinski
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120517 (2015)
The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosence
Externí odkaz:
https://doaj.org/article/0d35fea9865541e895abcebe1dd8023e
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89448 (2014)
Disruption of the Hedgehog signaling pathway has been implicated as an important molecular mechanism in the pathogenesis of fetal alcohol syndrome. In severe cases, the abnormalities of the face and brain that result from prenatal ethanol exposure fa
Externí odkaz:
https://doaj.org/article/ff9afc57459e433593597f62db921006
Autor:
Robert J Lipinski, Hunter T Holloway, Shonagh K O'Leary-Moore, Jacob J Ament, Stephen J Pecevich, Gary P Cofer, Francois Budin, Joshua L Everson, G Allan Johnson, Kathleen K Sulik
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102603 (2014)
Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have been limited to adolescent
Externí odkaz:
https://doaj.org/article/a44a4af0733e44ef83077693ea2498fc
Autor:
Alyssa E. Jenkins, Cameron O. Scarlett, Tyler G. Beames, Kenneth S. Rivera-González, Alexander A. Martin, Miranda R. Sun, Paul R. Hutson, Robert J. Lipinski
Publikováno v:
Toxicology Reports, Vol 11, Iss , Pp 310-317 (2023)
Piperonyl butoxide (PBO) is a popular insecticide synergist present in thousands of commercial, agricultural, and household products. PBO inhibits cytochrome P450 activity, impairing the ability of insects to detoxify insecticides. PBO was recently d
Externí odkaz:
https://doaj.org/article/d969be1796154876ab493f0125a82c11
Autor:
Robert J Lipinski, Peter Hammond, Shonagh K O'Leary-Moore, Jacob J Ament, Stephen J Pecevich, Yi Jiang, Francois Budin, Scott E Parnell, Michael Suttie, Elizabeth A Godin, Joshua L Everson, Deborah B Dehart, Ipek Oguz, Hunter T Holloway, Martin A Styner, G Allan Johnson, Kathleen K Sulik
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43067 (2012)
Prenatal ethanol exposure is the leading preventable cause of congenital mental disability. Whereas a diagnosis of fetal alcohol syndrome (FAS) requires identification of a specific pattern of craniofacial dysmorphology, most individuals with behavio
Externí odkaz:
https://doaj.org/article/f002b2c989d34d4bb0b782c406b0b246
Autor:
Kelsey Robinson, Trenell J. Mosley, Kenneth S. Rivera-González, Christopher R. Jabbarpour, Sarah W. Curtis, Wasiu Lanre Adeyemo, Terri H. Beaty, Azeez Butali, Carmen J. Buxó, David J. Cutler, Michael P. Epstein, Lord J.J. Gowans, Jacqueline T. Hecht, Jeffrey C. Murray, Gary M. Shaw, Lina Moreno Uribe, Seth M. Weinberg, Harrison Brand, Mary L. Marazita, Robert J. Lipinski, Elizabeth J. Leslie
Publikováno v:
HGG Advances, Vol 4, Iss 4, Pp 100234- (2023)
Summary: Cleft palate (CP) is one of the most common craniofacial birth defects; however, there are relatively few established genetic risk factors associated with its occurrence despite high heritability. Historically, CP has been studied as a singl
Externí odkaz:
https://doaj.org/article/d701a794d6d64abda81ebac6e8be9898
Autor:
Brian P. Johnson, Ross A. Vitek, Molly M. Morgan, Dustin M. Fink, Tyler G. Beames, Peter G. Geiger, David J. Beebe, Robert J. Lipinski
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Paracrine signaling in the tissue microenvironment is a central mediator of morphogenesis, and modeling this dynamic intercellular activity in vitro is critical to understanding normal and abnormal development. For example, Sonic Hedgehog (Shh) signa
Externí odkaz:
https://doaj.org/article/d8b3b36fea6a41af81b6b68e4013d24d
Autor:
Matthew T. McLaughlin, Miranda R. Sun, Tyler G. Beames, Austin C. Steward, Joshua W. M. Theisen, Hannah M. Chung, Joshua L. Everson, Ivan P. Moskowitz, Michael D. Sheets, Robert J. Lipinski
Publikováno v:
Developmental Dynamics. 252:483-494
Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development.During midfacial morphogenesis in mice, we observed Frem1 expression in the embry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9f221212df12422809ee1e27ec2746
https://doi.org/10.1002/dvdy.555
https://doi.org/10.1002/dvdy.555
Autor:
Robert J. Lipinski, Robert S. Krauss
Publikováno v:
Current Topics in Developmental Biology ISBN: 9780128201572
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81ec7ee0f9f49e06d4b7b10a92df487d
https://doi.org/10.1016/s0070-2153(23)00028-5
https://doi.org/10.1016/s0070-2153(23)00028-5
