Zobrazeno 1 - 10
of 1 295
pro vyhledávání: '"Robert J Linhardt"'
Autor:
Gretchen T Clark, Yanlei Yu, Cooper A Urban, Guo Fu, Chunyu Wang, Fuming Zhang, Robert J Linhardt, Jennifer M Hurley
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1009994 (2022)
Alzheimer's Disease (AD) is a neuroinflammatory disease characterized partly by the inability to clear, and subsequent build-up, of amyloid-beta (Aβ). AD has a bi-directional relationship with circadian disruption (CD) with sleep disturbances starti
Externí odkaz:
https://doaj.org/article/f1812de39f4e451d97c846f31d199435
Autor:
Dipanwita Mitra, Mohammad H Hasan, John T Bates, Michael A Bierdeman, Dallas R Ederer, Rinkuben C Parmar, Lauren A Fassero, Quntao Liang, Hong Qiu, Vaibhav Tiwari, Fuming Zhang, Robert J Linhardt, Joshua S Sharp, Lianchun Wang, Ritesh Tandon
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009803 (2021)
Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus
Externí odkaz:
https://doaj.org/article/494ffbd93696441bb2b9787e8edc5fbf
Autor:
Thomas Hart, Ngoc Thien Thu Nguyen, Nancy A Nowak, Fuming Zhang, Robert J Linhardt, Maria Diuk-Wasser, Sanjay Ram, Peter Kraiczy, Yi-Pin Lin
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007106 (2018)
Borrelia burgdorferi sensu lato (Bbsl), the causative agent of Lyme disease, establishes an initial infection in the host's skin following a tick bite, and then disseminates to distant organs, leading to multisystem manifestations. Tick-to-vertebrate
Externí odkaz:
https://doaj.org/article/6efc2501d2174b3dacfa6a878429194a
Autor:
Esam S. Al-Malki, Omar A. Ahmed-Farid, Mahmoud M.A. Moustafa, Shimaa A. Haredy, Omnia A. Badr, Nesreen Nabil Omar, Robert J. Linhardt, Mohamad Warda
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02177- (2024)
Obesity stands as a pervasive and significant global health issue, with a lack of definitive and curative therapeutic solutions currently available. Here we studied the synergetic ameliorating effect of coupled administration of GABA agonist; baclofe
Externí odkaz:
https://doaj.org/article/1411bb3195514a54835824df4b588c47
Autor:
Xiaohua Wang, Xinyue Liu, Lingyun Li, Fuming Zhang, Min Hu, Fuji Ren, Lianli Chi, Robert J Linhardt
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167727 (2016)
Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, and automatic structural a
Externí odkaz:
https://doaj.org/article/43a0b9b350f84c27a9156c8758c050be
Autor:
Kyohei Higashi, Yoshiki Takeuchi, Ann Mukuno, Hideyuki Tomitori, Masaki Miya, Robert J Linhardt, Toshihiko Toida
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120860 (2015)
Shark fin, used as a food, is a rich source of glycosaminoglyans (GAGs), acidic polysaccharides having important biological activities, suggesting their nutraceutical and pharmaceutical application. A comprehensive survey of GAGs derived from the fin
Externí odkaz:
https://doaj.org/article/728f202e1bb04c76a0ccaccb2b0649f2
Autor:
Nicholas J Schaub, Clémentine Le Beux, Jianjun Miao, Robert J Linhardt, Johan G Alauzun, Danielle Laurencin, Ryan J Gilbert
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136780 (2015)
The surface of aligned, electrospun poly-L-lactic acid (PLLA) fibers was chemically modified to determine if surface chemistry and hydrophilicity could improve neurite extension from chick dorsal root ganglia. Specifically, diethylenetriamine (DTA, f
Externí odkaz:
https://doaj.org/article/91e1d00c771d4623b42065cebfcd1a94
Autor:
Jiyuan Yang, Yuefan Song, Ke Xia, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
Publikováno v:
Marine Drugs, Vol 22, Iss 5, p 232 (2024)
Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate,
Externí odkaz:
https://doaj.org/article/67ebfea3f0544ab5bdfa9a3a29c24e5e
Autor:
Paul S. Kwon, Shirley Xu, Hanseul Oh, Seok-Joon Kwon, Andre L. Rodrigues, Maisha Feroz, Keith Fraser, Peng He, Fuming Zhang, Jung Joo Hong, Robert J. Linhardt, Jonathan S. Dordick
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on SARS-CoV-2 RBDs with preferential binding for Omicron RBD and inhibition of infection by the Omicron variant in vitro.
Externí odkaz:
https://doaj.org/article/f9c4ce0ff01c4a649d774200f246e2fd
Autor:
Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Pham, Jian Liu, Fuming Zhang, Andrew Almond, Robert J. Linhardt, Paul L. DeAngelis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccha
Externí odkaz:
https://doaj.org/article/ef461400591343048c9e59e0041eaaf1