Zobrazeno 1 - 10
of 772
pro vyhledávání: '"Robert J Lefkowitz"'
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283477 (2023)
G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins. [Sarcosine1Ile4Ile8]-angiotensin II (SII), an analog of the endogenous ligand angiotensin
Externí odkaz:
https://doaj.org/article/1626b8ed14aa479c84ac966c7bfe159b
Autor:
Elie Simard, Jeffrey J Kovacs, William E Miller, Jihee Kim, Michel Grandbois, Robert J Lefkowitz
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80532 (2013)
Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2. Previous studi
Externí odkaz:
https://doaj.org/article/279ad1828946470991abc1ac94b5680f
Autor:
Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, Milton Packer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/1516c52dd4af4fd98dff325b5997c3e9
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Autor:
Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, Robert J. Lefkowitz
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β2AR stimulation on skeletal muscle is anabolic gr
Externí odkaz:
https://doaj.org/article/23829cd6bf1d4dbe84a5e0112c5c0274
Autor:
Paula K. Rambarat, Biswaranjan Pani, Robert J. Lefkowitz, Shashank Vege, Seungkirl Ahn, Dean P. Staus, Bruno N. Valan, Tommaso Costa, Alem W. Kahsai, Andrew Liu
Publikováno v:
Molecular Pharmacology. 100:513-525
Among β-blockers that are clinically prescribed for heart failure, carvedilol is a first-choice agent with unique pharmacological properties. Carvedilol is distinct from other β-blockers in its ability to elicit β-arrestin-biased agonism, which ha
Autor:
Seungkirl Ahn, Howard A. Rockman, Haoran Jiang, Ilhan Gokhan, Jialu Wang, Xinyu Xiong, Biswaranjan Pani, Robert J. Lefkowitz, Alem W. Kahsai
Publikováno v:
Mol Pharmacol
β(1) adrenergic receptors (β(1)ARs) are central regulators of cardiac function and a drug target for cardiac disease. As a member of the G protein–coupled receptor family, β(1)ARs activate cellular signaling by primarily coupling to Gs proteins
Publikováno v:
The FASEB Journal. 36
Publikováno v:
The Journal of Biological Chemistry
G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor
Autor:
Wayne L. Hubbell, Andrew C. Kruse, Robert J. Lefkowitz, Conor McMahon, Howard A. Rockman, Matthias Elgeti, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Dean P. Staus
Publikováno v:
Proc Natl Acad Sci U S A
There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the che
Autor:
Robert J. Lefkowitz, Alissa L. W. Kleinhenz, Meredith A. Skiba, Andrew C. Kruse, Carl-Mikael Suomivuori, Conor McMahon, Dean P. Staus, Ron O. Dror, Naomi R. Latorraca, Laura M. Wingler
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin