Zobrazeno 1 - 10
of 767
pro vyhledávání: '"Robert J Lee"'
Autor:
Alasdair J Gray, Carl Roobottom, Jason E Smith, Steve Goodacre, Katherine Oatey, Rachel O’Brien, Robert F Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Robert J Lee, Praveen Thokala, Steff C Lewis, David E Newby
Publikováno v:
Health Technology Assessment, Vol 26, Iss 37 (2022)
Background: Acute coronary syndrome is a common medical emergency. The optimal strategy to investigate patients who are at intermediate risk of acute coronary syndrome has not been fully determined. Objective: To investigate the role of early compute
Externí odkaz:
https://doaj.org/article/72ccd923fd1b453694bf1f50d0351923
Autor:
John Norrie, Sarrah Peerbux, Nicky Cullum, Akila Chandrasekar, Richard Lomas, Andrew Bradbury, Karen Dhillon, Sarah Onida, Francine Heatley, Layla Bolton, Tristan Lane, David Epstein, Manjit Gohel, Keith Poskitt, Robert J Lee, A H Davies
Publikováno v:
BMJ Open, Vol 11, Iss 4 (2021)
Introduction Venous leg ulceration (VLU), the most common type of chronic ulcer, can be difficult to heal and is a major cause of morbidity and reduced quality of life. Although compression bandaging is the principal treatment, it is time-consuming a
Externí odkaz:
https://doaj.org/article/7bc3bfdfc4e64e578f946f80b2275db5
Autor:
Benjamin M Hariri, Derek B McMahon, Bei Chen, Nithin D Adappa, James N Palmer, David W Kennedy, Robert J Lee
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185203 (2017)
Flavones are a class of natural plant secondary metabolites that have anti-inflammatory and anti-bacterial effects. Some flavones also activate the T2R14 bitter taste receptor, which is expressed in motile cilia of the sinonasal epithelium and activa
Externí odkaz:
https://doaj.org/article/953da24cd2814b62bed485f933dda7b2
Autor:
Mengqiao Wang, Robert J Lee, Ye Bi, Lianlian Li, Guodong Yan, Jiahui Lu, Qingfan Meng, Lesheng Teng, Jing Xie
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186821 (2017)
A series of 1,2-dihydroquinoline derivatives were synthesized and evaluated for cytotoxicity in HeLa, Hep G2 and 6HEK-293T cell lines. EEDQ2 was identified as a promising anti-cancer agent with low IC50 in HeLa (18.55μg/ml) and Hep G2 (14.53μg/ml)
Externí odkaz:
https://doaj.org/article/92f59d145eae446595518d82d6bca098
Autor:
Zoey A. Miller, Sahil Muthuswami, Arielle Mueller, Ray Z. Ma, Sarah M. Sywanycz, Anusha Naik, Lily Huang, Robert M. Brody, Ahmed Diab, Ryan M. Carey, Robert J. Lee
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Head and neck squamous cell carcinomas (HNSCCs) are cancers that arise in the mucosa of the upper aerodigestive tract. The five-year patient survival rate is ~50%. Treatment includes surgery, radiation, and/or chemotherapy and is associated
Externí odkaz:
https://doaj.org/article/e909d22d50b646d9a54955aa5ffc4686
Autor:
Xuewei Yang, Shuang Yang, Hongyu Chai, Zhaogang Yang, Robert J Lee, Weiwei Liao, Lesheng Teng
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136649 (2015)
We have screened 11 isoquinoline derivatives and α-methylene-γ-butyrolactones using the 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HeLa and HEK-293T cells. Compound 2 was identified as potential antica
Externí odkaz:
https://doaj.org/article/c8833c7d5b6c4d1bac430fbdfc3b33dc
Autor:
Li Zhang, Zhenxing Sun, Pingping Ren, Robert J Lee, Guangya Xiang, Qing Lv, Wei Han, Jing Wang, Shuping Ge, Mingxing Xie
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134629 (2015)
Gene therapy has great potential for human diseases. Development of efficient delivery systems is critical to its clinical translation. Recent studies have shown that microbubbles in combination with ultrasound (US) can be used to facilitate gene del
Externí odkaz:
https://doaj.org/article/929f076ef90c46cd8e051e0305e4364b
Autor:
Yun Wu, Melissa Crawford, Yicheng Mao, Robert J Lee, Ian C Davis, Terry S Elton, L James Lee, Serge P Nana-Sinkam
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
MicroRNA-29b (miR-29b) expression has been shown to be reduced in non-small–cell lung cancer (NSCLC) tissues. Here, we have identified the oncogene cyclin-dependent protein kinase 6 (CDK6) as a direct target of miR-29b in lung cancer. We hypothesiz
Externí odkaz:
https://doaj.org/article/6b9f9ac9debf40c292212de43cecb6ba
Autor:
Yang Liu, Sergio Corrales-Guerrero, Jimmy C. Kuo, Ryan Robb, Gregory Nagy, Tiantian Cui, Robert J. Lee, Terence M. Williams
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 977-987 (2023)
Externí odkaz:
https://doaj.org/article/e10d5d41c2e34d0e947d15747200eea5
Autor:
Tianyao Huo, Rolf F Barth, Weilian Yang, Robin J Nakkula, Rumiana Koynova, Boris Tenchov, Abhik Ray Chaudhury, Lawrence Agius, Teni Boulikas, Helene Elleaume, Robert J Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48752 (2012)
The purpose of this study was to evaluate two novel liposomal formulations of cisplatin as potential therapeutic agents for treatment of the F98 rat glioma. The first was a commercially produced agent, Lipoplatin™, which currently is in a Phase III
Externí odkaz:
https://doaj.org/article/1b6974913ecb4eb8845048e6d64fdfc4