Development of an AT2-deficient proximal tubule cell line for transport studies

Autor: Tadashi Inagami, Robert J. Kolb, Philip G. Woost, Ulrich Hopfer, Margaret Finesilver, Chung-Ho Chang

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 43:352-360

Angiotensin II is a major regulatory peptide for proximal tubule Na(+) reabsorption acting through two distinct receptor subtypes: AT(1) and AT(2). Physiological or pathological roles of AT(2) have been difficult to unravel because angiotensin II can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffd903b444c1c65a98df10185b54a41
https://doi.org/10.1007/s11626-007-9061-1

α-Actinin-4 Is Required for Normal Podocyte Adhesion

Autor: Robert J. Kolb, Raghu Kalluri, Martin R. Pollak, Savita V. Dandapani, Sumita Sinha, Benjamin D. Matthews, Robert E. Gerszten, Jing Zhou, Hikaru Sugimoto, Donald E. Ingber

Publikováno v: Journal of Biological Chemistry. 282:467-477

Mutations in the alpha-actinin-4 gene ACTN4 cause an autosomal dominant human kidney disease. Mice deficient in alpha-actinin-4 develop a recessive phenotype characterized by kidney failure, proteinuria, glomerulosclerosis, and retraction of glomerul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb0e4342260f284bd958e2f17f69506
https://doi.org/10.1074/jbc.m605024200

Global cytoskeletal control of mechanotransduction in kidney epithelial cells

Autor: Surya M. Nauli, Francis J. Alenghat, Donald E. Ingber, Jing Zhou, Robert J. Kolb

Publikováno v: Experimental Cell Research. 301:23-30

Studies of mechanotransduction mediated by stress-sensitive ion channels generally focus on the site of force application to the cell. Here we show that global, cell-wide changes in cytoskeletal structure and mechanics can regulate mechanotransductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fba1eab2ec1e43469313d71790f3fa
https://doi.org/10.1016/j.yexcr.2004.08.003

Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors

Autor: Robert J. Kolb, Monika Gooz, Jennifer Guare, Takamitsu Saigusa, P. Darwin Bell, Robert A. Fenton, Ryan J. Reichert, Brian J. Siroky, Stacy L. Steele

Publikováno v: Saigusa, T, Reichert, R, Guare, J, Siroky, B J, Gooz, M, Steele, S, Fenton, R A, Bell, P D & Kolb, R J 2012, ' Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors ', A J P: Renal Physiology (Online), vol. 302, no. 7, pp. F801-8 . https://doi.org/10.1152/ajprenal.00253.2011

Polycystic kidney disease (PKD) is a ciliopathy characterized by renal cysts and hypertension. These changes are presumably due to altered fluid and electrolyte transport in the collecting duct (CD). This is the site where vasopressin (AVP) stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9d240361391ca82a80094ea4725909
https://pubmed.ncbi.nlm.nih.gov/22205228

Microarray profile of gene expression during osteoclast differentiation in modelled microgravity

Autor: Jeremy J. Blanchard, Giffin Daughtridge, Ted A. Bateman, Sakamuri V. Reddy, Yuvaraj Sambandam, Robert J. Kolb, Srinivasan Shanmugarajan, Subramanya Pandruvada

Publikováno v: Journal of cellular biochemistry. 111(5)

Microgravity (µXg) leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast (OCL) is the multinucleated bone-resorbing cell. In this study, we used the NASA developed ground-based rotating wall vessel bioreactor (RWV), rotar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8184d967795d16ceaf24d8f7b0da74
https://pubmed.ncbi.nlm.nih.gov/20717918