Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert J Guttendorf"'
Autor:
Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky, Harry LeVine, Michael Grundman, Anthony O. Caggiano, John R. Cirrito, Susan M. Catalano, Mary E. Hamby
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/19f084bea18e49d6b821e4355697a8ba
Autor:
Misty Williams, Robert J Guttendorf, John Keating, David W. Trost, Christopher Scull, Pauline E McEwan, Lynn Bailey
Publikováno v:
International journal of toxicology. 37(6)
Regional therapies for metastatic liver disease have garnered interest in recent years due to technological advances in drug delivery. A percutaneous hepatic perfusion (PHP) using a newly developed generation 2 (GEN2) filtration system was designed t
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:689-696
Cefdinir (Omnicef; Abbott Laboratories) is a cephalosporin antibiotic primarily eliminated by the kidney. Nonlinear renal elimination of cefdinir has been previously reported. Cefdinir renal transport mechanisms were studied in the erythrocyte-free i
Autor:
Edward J. Randinitis, Martin A. Shapiro, Robert J. Guttendorf, Joanne I. Brodfuehrer, Gaye H. Humphrey
Publikováno v:
The Journal of Clinical Pharmacology. 39:1143-1150
The pharmacokinetics of R-clinafloxacin and S-clinafloxacin enantiomers of the broad-spectrum fluoroquinolone antibiotic, clinafloxacin, were characterized in selected volunteer subjects and patients after the administration of oral and intravenous d
Autor:
Robert J. Guttendorf, Larry D. Andress
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 698:171-179
CI-1004 and PD 138389 (internal standard, I.S.), were isolated from rat, rabbit, dog, monkey and human plasma by solid-phase extraction with Bond-Elut C18 cartridges. Liquid chromatographic separation was achieved isocratically on a Zorbax Rx-C8 anal
Autor:
John M. Domagala, J. Ronald Rubin, J. V. N. Vara Prasad, Eric L. Reyner, Peter J. Tummino, Donna Ferguson, Robert J. Guttendorf, Elizabeth A. Lunney, Barbra H. Stewart
Publikováno v:
Journal of the American Chemical Society. 117:11070-11074
Autor:
Robert J. Guttendorf, Peter J. Wedlund
Publikováno v:
The Journal of Clinical Pharmacology. 32:107-117
Autor:
Robert A. Blouin, KA Pittman, Peter J. Wedlund, M Britto, T S Foster, Robert J. Guttendorf, W J John
Publikováno v:
British Journal of Clinical Pharmacology. 29:373-380
1. The phenotyping parameters for dextromethorphan and mephenytoin were assessed in 48 normal male volunteers following administration of each metabolic probe drug on separate occasions and together according to a randomized 3-way crossover design. 2
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 709(2)
Achiral and chiral HPLC methods were developed for clinafloxacin, a quinolone antimicrobial agent. For achiral assay, analytes were isolated from plasma by precipitating plasma proteins. Separation was achieved on a C 18 column using an isocratic elu
Autor:
Kimberly Suzanne Para, Elizabeth A. Lunney, Eric L. Reyner, Stephen J. Gracheck, Andrea Heldsinger, Steve Vander Roest, Robert J. Guttendorf, John M. Domagala, Barbra H. Stewart, J. V. N. Vara Prasad, James Saunders, Donna Ferguson, Thomas J. McQuade, Peter J. Tummino
Publikováno v:
Biochemical and biophysical research communications. 221(3)
A systematic study of tethering various groups on 6-phenyl ring of 4-hydroxy-6-phenyl-3-[(2-iso-propylphenyl)thio]pyran-2-one was performed to increase the binding affinity with HIV protease. This tethering approach was aimed to fill S 3 pocket of th