Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Robert J Geraghty"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006421 (2018)
Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome. Nucleobas
Externí odkaz:
https://doaj.org/article/d8ead790a6994e6c9c9761aa9d4e5b46
Autor:
Sameera Senaweera, Tiffany C. Edwards, Jayakanth Kankanala, Yan Wang, Rajkumar Lalji Sahani, Jiashu Xie, Robert J. Geraghty, Zhengqiang Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1671-1684 (2022)
Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit
Externí odkaz:
https://doaj.org/article/47991bb3b5b9454b89bc80226a0ef4f1
Autor:
Ryuichi Majima, Tiffany C. Edwards, Christine D. Dreis, Robert J. Geraghty, Laurent F. Bonnac
Publikováno v:
Molecules, Vol 28, Iss 6, p 2616 (2023)
We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues. Th
Externí odkaz:
https://doaj.org/article/df2170f98c8e4a4ebf527765604c7473
Autor:
Zhengqiang Wang, Robert J. Geraghty
Publikováno v:
Viruses, Vol 15, Iss 3, p 740 (2023)
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]
Externí odkaz:
https://doaj.org/article/4d4c2f3c30c043d1b09eaa1b8d857c27
Publikováno v:
Molecules, Vol 27, Iss 18, p 6109 (2022)
To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral acti
Externí odkaz:
https://doaj.org/article/f944d6773a5b4f69b532981979d310bc
Autor:
Ruben Soto-Acosta, Tiffany C. Edwards, Christine D. Dreis, Venkatramana D. Krishna, Maxim C-J. Cheeran, Li Qiu, Jiashu Xie, Laurent F. Bonnac, Robert J. Geraghty
Publikováno v:
Viruses, Vol 13, Iss 12, p 2508 (2021)
Broad-spectrum antiviral therapies hold promise as a first-line defense against emerging viruses by blunting illness severity and spread until vaccines and virus-specific antivirals are developed. The nucleobase favipiravir, often discussed as a broa
Externí odkaz:
https://doaj.org/article/4ed7d485443143e19662aa390f9377fb
Autor:
Tianyu He, Tiffany C. Edwards, Jiashu Xie, Hideki Aihara, Robert J. Geraghty, Zhengqiang Wang
Publikováno v:
J Med Chem
Human cytomegalovirus (HCMV) terminase complex entails a metal-dependent endonuclease at the C-terminus of pUL89 (pUL89-C). We report herein the design, synthesis, and characterization of dihydroxypyrimidine (DHP) acid (14), methyl ester (13), and am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9f3e732f5ad4d0d4f678d6a7d2dc32
https://pubmed.ncbi.nlm.nih.gov/35377638
https://pubmed.ncbi.nlm.nih.gov/35377638
Publikováno v:
Molecules, Vol 26, Iss 13, p 3779 (2021)
Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyr
Externí odkaz:
https://doaj.org/article/4eb03b91a3d74e30a93c520ef7dcb865
Publikováno v:
Viruses, Vol 13, Iss 4, p 667 (2021)
The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of
Externí odkaz:
https://doaj.org/article/2aad3b9579a3437f862d8ed9e6628b9c
Autor:
Rajkumar Lalji Sahani, Yan Wang, Jiashu Xie, Robert J. Geraghty, Sameera Senaweera, Jayakanth Kankanala, Zhengqiang Wang, Tiffany C. Edwards
Publikováno v:
Acta Pharmaceutica Sinica B. 12:1671-1684
Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d95d5675f5627cdee7f9361d51ebdd6
https://doi.org/10.1016/j.apsb.2021.08.019
https://doi.org/10.1016/j.apsb.2021.08.019