Výsledky vyhledávání - "Robert J Doll"

Akademický článek

Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study

Autor: Ahnjili Zhuparris, Ghobad Maleki, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Wessel Kraaij, Adam Cohen, Emilie van Brummelen, Joris H De Maeyer, Geert Jan Groeneveld

Publikováno v: JMIR Formative Research, Vol 7, p e41178 (2023)

BackgroundFacioscapulohumeral muscular dystrophy (FSHD) is a progressive neuromuscular disease. Its slow and variable progression makes the development of new treatments highly dependent on validated biomarkers that can quantify disease progression a

Externí odkaz: https://doaj.org/article/c5a6cd27a6b845faade9571d311e4f24

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Akademický článek

Objective Monitoring of Facioscapulohumeral Dystrophy During Clinical Trials Using a Smartphone App and Wearables: Observational Study

Autor: Ghobad Maleki, Ahnjili Zhuparris, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Adam Cohen, Emilie van Brummelen, Geert Jan Groeneveld, Joris De Maeyer

Publikováno v: JMIR Formative Research, Vol 6, Iss 9, p e31775 (2022)

BackgroundFacioscapulohumeral dystrophy (FSHD) is a progressive muscle dystrophy disorder leading to significant disability. Currently, FSHD symptom severity is assessed by clinical assessments such as the FSHD clinical score and the Timed Up-and-Go

Externí odkaz: https://doaj.org/article/83e300e279f542c8b92fe47103e5e823

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Akademický článek

Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial

Autor: Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll

Publikováno v: JMIR Formative Research, Vol 5, Iss 12, p e31890 (2021)

BackgroundAlthough electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for inex

Externí odkaz: https://doaj.org/article/fe94b180e6264e17bc5369110d805b11

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Akademický článek

Touchscreen-based finger tapping: Repeatability and configuration effects on tapping performance.

Autor: Soma Makai-Bölöni, Eva Thijssen, Emilie M J van Brummelen, Geert J Groeneveld, Robert J Doll

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0260783 (2021)

Parkinson's disease (PD) is a progressive neurodegenerative disease that affects almost 2% of the population above the age of 65. To better quantify the effects of new medications, fast and objective methods are needed. Touchscreen-based tapping task

Externí odkaz: https://doaj.org/article/0fbfa01961614b828a9a1392cfc69319

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Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study (Preprint)

Autor: Ahnjili Zhuparris, Ghobad Maleki, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Wessel Kraaij, Adam Cohen, Emilie van Brummelen, Joris H De Maeyer, Geert Jan Groeneveld

BACKGROUND Facioscapulohumeral muscular dystrophy (FSHD) is a progressive neuromuscular disease. Its slow and variable progression makes the development of new treatments highly dependent on validated biomarkers that can quantify disease progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4872f0b15bc76146b60b114614ac792
https://doi.org/10.2196/preprints.41178

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Transcranial magnetic stimulation as biomarker of excitability in drug development: a randomized, double-blind, placebo-controlled, cross-over study

Autor: Titia Q. Ruijs, Jules A. A. C. Heuberger, Annika A. de Goede, Dimitrios Ziagkos, Marije E. Otto, Robert J. Doll, Michel J. A. M. van Putten, Geert Jan Groeneveld

Publikováno v: British Journal of Clinical Pharmacology, 88(6), 2926-2937. WILEY
British journal of clinical pharmacology, 88(6), 2926-2937. Wiley-Blackwell

Aims The purpose of this study was to investigate pharmacodynamic effects of drugs targeting cortical excitability using transcranial magnetic stimulation (TMS) combined with electromyography (EMG) and electroencephalography (EEG) in healthy subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9e0d067eecc8cbbe57969c46f9c6e9
http://hdl.handle.net/1887/3572093

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Simultaneous measurement of intra-epidermal electric detection thresholds and evoked potentials for observation of nociceptive processing following sleep deprivation

Autor: Boudewijn van den Berg, Hemme J. Hijma, Ingrid Koopmans, Robert J. Doll, Rob G. J. A. Zuiker, Geert Jan Groeneveld, Jan R. Buitenweg

Publikováno v: Experimental Brain Research
Experimental brain research, 240(2), 631-649. Springer
Experimental Brain Research, 240(2), 631-649. SPRINGER

Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds in healthy subjects. In chronic pain patients, sleep impairment often worsens the perceived pain intensity. This increased pain perception is the result of alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc09f1fc444e30751a19f70ab4bdfc
https://pubmed.ncbi.nlm.nih.gov/34993590

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Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial (Preprint)

Autor: Willem O Elzinga, Samantha Prins, Laura G J M Borghans, Pim Gal, Gabriel A Vargas, Geert J Groeneveld, Robert J Doll

BACKGROUND Although electrocardiography is the gold standard for heart rate (HR) recording in clinical trials, the increasing availability of smartwatch-based HR monitors opens up possibilities for drug development studies. Smartwatches allow for ine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bc0c714f2c260eef10d1f8ca0f4cb05
https://doi.org/10.2196/preprints.31890

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