Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Robert J DeVita"'
Autor:
Eric S Muise, Yonghua Zhu, Andreas Verras, Bindhu V Karanam, Judith Gorski, Drew Weingarth, Hua V Lin, Joyce Hwa, John R Thompson, Guanghui Hu, Jian Liu, Shuwen He, Robert J DeVita, Dong-Ming Shen, Shirly Pinto
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88908 (2014)
Inhibition of Diacylglycerol O-acyltransferase 1 (DGAT1) has been a mechanism of interest for metabolic disorders. DGAT1 inhibition has been shown to be a key regulator in an array of metabolic pathways; however, based on the DGAT1 KO mouse phenotype
Externí odkaz:
https://doaj.org/article/30e9e8bd71054d76b522294eff1de235
Autor:
Mehdi Yeganeh, Christiane Auray‐Blais, Bruno Maranda, Amanda Sabovic, Robert J. DeVita, Michael B. Lazarus, Sander M. Houten
Publikováno v:
JIMD Reports, Vol 64, Iss 6, Pp 440-445 (2023)
Abstract Hyperlysinemia is a rare autosomal recessive deficiency of 2‐aminoadipic semialdehyde synthase (AASS) affecting the initial step in lysine degradation. It is thought to be a benign biochemical abnormality, but reports on cases remain scarc
Externí odkaz:
https://doaj.org/article/103b38baeae4401682c5bdb0acf2a50e
Autor:
João Leandro, Susmita Khamrui, Chalada Suebsuwong, Peng-Jen Chen, Cody Secor, Tetyana Dodatko, Chunli Yu, Roberto Sanchez, Robert J. DeVita, Sander M. Houten, Michael B. Lazarus
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyses the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both lysine-2-oxoglutarate reductase (LOR) and
Externí odkaz:
https://doaj.org/article/5d1f92da3b604957856043910867cf16
Autor:
Peng Wang, Esra Karakose, Lauryn Choleva, Kunal Kumar, Robert J. DeVita, Adolfo Garcia-Ocaña, Andrew F. Stewart
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a major contributor to all common forms of diabetes. This is the underlying premise for attempts to replace beta cells in people with diabetes by pancreas tr
Externí odkaz:
https://doaj.org/article/afbe04c366a34476897b46b01b7cd797
Autor:
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro
Toxicity of accumulating substrates is a significant problem in several disorders of valine and isoleucine degradation notably short-chain enoyl-CoA hydratase (ECHS1 or crotonase) deficiency, 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency, prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c7ef83a0ddb32aed7b9feba155142
https://doi.org/10.1101/2022.11.22.517273
https://doi.org/10.1101/2022.11.22.517273
Autor:
null João Leandro, null Susmita Khamrui, null Chalada Suebsuwong, null Peng-Jen Chen, null Cody Secor, null Tetyana Dodatko, null Chunli Yu, null Roberto Sanchez, null Robert J. DeVita, null Sander M. Houten, null Michael B. Lazarus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2821e2ece457ef1b68e245110f6536c7
https://doi.org/10.1098/rsob.220179/v3/response1
https://doi.org/10.1098/rsob.220179/v3/response1
Autor:
KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Diabetes results from diminished functional β-cell mass. Small molecule inhibitors of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) markedly increase human β-cell replication in vitro and in vivo. Furthermore, combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0255f87330b1a87dd21556d1ef03f950
https://doi.org/10.2337/db22-822-p
https://doi.org/10.2337/db22-822-p
Autor:
CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
GLP1R agonists such as Exendin-4 (E) together with DYRK1A inhibitors such as Harmine (H) significantly increase human β-cell replication in vitro and in vivo. Importantly, 3-month treatment with H+E combination markedly increases human beta cell mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3409566a6a7e67f5f616972bc15dd62
https://doi.org/10.2337/db22-14-or
https://doi.org/10.2337/db22-14-or
Autor:
GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) results from loss of both immune tolerance and functional β-cells. Administration of harmine (H) plus exendin-4 (E) markedly induces human β-cell expansion. Anti-CD3 antibody treatment reduces C-peptide loss in T1D patients. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c65519c2fa9328c0b26cf64d1e5e271
https://doi.org/10.2337/db22-10-or
https://doi.org/10.2337/db22-10-or
Autor:
Robert J. DeVita, Andrew F. Stewart, Adolfo Garcia-Ocaña, Peng Wang, Kunal Kumar, Chalada Suebsuwong
Publikováno v:
Journal of Medicinal Chemistry. 64:2901-2922
According to the World Health Organization (WHO), 422 million people are suffering from diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose control to prevent long-term diabetes complications. Unfortunately, current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a78d091e1f547ca55906ac1a308cd4f
https://doi.org/10.1021/acs.jmedchem.0c02050
https://doi.org/10.1021/acs.jmedchem.0c02050