Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Robert J De Knegt"'
Autor:
Nicole S Erler, Robert J de Knegt, Jordan J Feld, Bettina E Hansen, Harry L A Janssen, Adriaan J van der Meer, Christoph Welsch, Stefan Zeuzem, Amy Puenpatom, Thomas Vanwolleghem, Robert A de Man, Lisette A P Krassenburg, Raoel Maan, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Background and aims Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasi
Externí odkaz:
https://doaj.org/article/20684bd7459a42a999c55f58c9c6cca6
Autor:
Manuel Castro Cabezas, Bas M van Dalen, Diederick E Grobbee, Ellen M van der Zwan, Jan A Apers, Robert J de Knegt, Danny A Kanhai, Willy B Theel, Bianca M Boxma-de Klerk, Femme Dirksmeier-Harinck, Elisabeth FC van Rossum, Bojou Neecke, Thomas Hankemeier, Janneke Wiebolt
Publikováno v:
BMJ Open, Vol 13, Iss 7 (2023)
Introduction The prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 25% in the general population to 90% in patients with obesity scheduled for bariatric surgery. NAFLD can progress towards non-alcoholic steatohepatitis (NASH) associ
Externí odkaz:
https://doaj.org/article/8a6f0ce46a8243819540b9c7a23b37cc
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0287467 (2023)
Accumulating evidence shows that NAFLD might play a role in the etiology and progression of CVD, but little is known on the association of NAFLD and CVD mortality in patients with a history of a myocardial infarction (MI). Therefore, we studied the r
Externí odkaz:
https://doaj.org/article/bf22552792594cbe883092f46eb6a1ed
Autor:
Stephanie Popping, Sebastiaan J Hullegie, Anne Boerekamps, Bart J A Rijnders, Robert J de Knegt, Jürgen K Rockstroh, Annelies Verbon, Charles A B Boucher, Brooke E Nichols, David A M C van de Vijver
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210179 (2019)
BackgroundTreatment of hepatitis C virus infections (HCV) with direct acting antivirals (DAA) can prevent new infections since cured individuals cannot transmit HCV. However, as DAAs are expensive, many countries defer treatment to advances stages of
Externí odkaz:
https://doaj.org/article/9cf3a1db260f4a0d9cfbe1ea5cae48ba
Autor:
Jesse Pustjens, Laurens A. van Kleef, Harry L.A. Janssen, Robert J. de Knegt, Willem P. Brouwer
Publikováno v:
JHEP Reports, Vol 6, Iss 12, Pp 101193- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly prevalent in the general population. This study aimed at describing the cardiometabolic burden of the MASLD population and to identify patien
Externí odkaz:
https://doaj.org/article/6c143003c18b4b4dbef143240f31c80b
Autor:
Michelle Spaan, Sebastiaan J Hullegie, Boris J B Beudeker, Kim Kreefft, Gertine W van Oord, Zwier M A Groothuismink, Marjolein van Tilborg, Bart Rijnders, Robert J de Knegt, Mark A A Claassen, Andre Boonstra
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159243 (2016)
Mucosal-associated invariant T (MAIT) cells comprise a subpopulation of T cells that can be activated by bacterial products and cytokines to produce IFN-γ. Since little is known on MAIT cells during HCV infection, we compared their phenotype and fun
Externí odkaz:
https://doaj.org/article/ceeec7d7dbc8492488ce103792aa7e08
Autor:
Floor A C Berden, Robert J de Knegt, Hans Blokzijl, Sjoerd D Kuiken, Karel J L van Erpecum, Sophie B Willemse, Jan den Hollander, Marit G A van Vonderen, Pieter Friederich, Bart van Hoek, Carin M J van Nieuwkerk, Joost P H Drenth, Wietske Kievit
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161821 (2016)
BACKGROUND:Approval of drugs in chronic hepatitis C is supported by registration trials. These trials might have limited generalizability through use of strict eligibility criteria. We compared effectiveness and safety of real world hepatitis C patie
Externí odkaz:
https://doaj.org/article/df63fcc0640b409ebc0d1424a0973708
Autor:
Raoel Maan, Adriaan J van der Meer, Willem Pieter Brouwer, Elisabeth P C Plompen, Milan J Sonneveld, Robert Roomer, Annemiek A van der Eijk, Zwier M A Groothuismink, Bettina E Hansen, Bart J Veldt, Harry L A Janssen, Andre Boonstra, Robert J de Knegt
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139317 (2015)
BACKGROUND/OBJECTIVE:Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection. The aim of
Externí odkaz:
https://doaj.org/article/90c09a9295144d4bbc02a649ba585bd1
Autor:
Mark A A Claassen, Robert J de Knegt, Duygu Turgut, Zwier M A Groothuismink, Harry L A Janssen, André Boonstra
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49389 (2012)
Specific inhibitory mechanisms suppress the T-cell response against the hepatitis C virus (HCV) in chronically infected patients. However, the relative importance of suppression by IL-10, TGF-β and regulatory T-cells and the impact of pegylated inte
Externí odkaz:
https://doaj.org/article/88b4bb4bf5f74b98b6805b23393e646d
Autor:
Wen-Yue Liu, Xiaofang Zhang, Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Rafael S. Rios, Kenneth I. Zheng, Hong-Lei Ma, Xiao-Dong Wang, Qiuwei Pan, Robert J. de Knegt, Luca Valenti, Mohsen Ghanbari, Ming-Hua Zheng
Publikováno v:
Clinical and Molecular Hepatology, Vol 28, Iss 2, Pp 183-195 (2022)
Background/Aims Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL) gene in human, has bee
Externí odkaz:
https://doaj.org/article/304fd94ed6344d8da667b59bde02db3d