Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Robert J De Knegt"'
Autor:
Sylvia M. Brakenhoff, Thymen Theijse, Peter van Wijngaarden, Christian Trautwein, Jonathan F. Brozat, Frank Tacke, Pieter Honkoop, Thomas Vanwolleghem, Dirk Posthouwer, Stefan Zeuzem, Ulrike Mihm, Heiner Wedemeyer, Thomas Berg, Solko W. Schalm, Robert J. de Knegt
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background and Aims Systematic reviews and medical guidelines are widely used in clinical practice. However, these are often not up-to-date and focussed on the average patient. We therefore aimed to evaluate a guideline add-on, TherapySelect
Externí odkaz:
https://doaj.org/article/c576f08441324371baa5a462203e8cd0
Autor:
Jesse Pustjens, Laurens A. van Kleef, Harry L.A. Janssen, Robert J. de Knegt, Willem P. Brouwer
Publikováno v:
JHEP Reports, Vol 6, Iss 12, Pp 101193- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly prevalent in the general population. This study aimed at describing the cardiometabolic burden of the MASLD population and to identify patien
Externí odkaz:
https://doaj.org/article/6c143003c18b4b4dbef143240f31c80b
Autor:
Sylvia M. Brakenhoff, Heng Chi, Pieter Friederich, Michail Doukas, Caroline den Hoed, Hajo J. Flink, Robert J. de Knegt, Robert A. de Man
Publikováno v:
Case Reports in Gastroenterology, Vol 18, Iss 1, Pp 252-259 (2024)
Introduction: Emerging evidence suggests that long-term nucleos(t)ide analogue (NA) therapy can be ceased in a selective group of chronic hepatitis B (CHB). This is being gradually implemented in clinical practice. Case Presentation: A 68-year-old ma
Externí odkaz:
https://doaj.org/article/b5104e93061d4d369b3810d06033a46f
Autor:
Boris J.B. Beudeker, Zgjim Osmani, Gertine W. van Oord, Zwier M.A. Groothuismink, Robert J. de Knegt, Remco M. Hoogenboezem, Eric M.J. Bindels, Harmen J.G. van de Werken, Andre Boonstra
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100980- (2024)
Background & Aims: HBsAg secretion may impact immune responses to chronic HBV infection. Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory effects of high and low levels o
Externí odkaz:
https://doaj.org/article/542efaeae0b24074ae10f0b1e8f00943
Autor:
Nicole S Erler, Robert J de Knegt, Jordan J Feld, Bettina E Hansen, Harry L A Janssen, Adriaan J van der Meer, Christoph Welsch, Stefan Zeuzem, Amy Puenpatom, Thomas Vanwolleghem, Robert A de Man, Lisette A P Krassenburg, Raoel Maan, Stijn van Hees, Orlando Cerrhoci, Johannes Vermehren
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Background and aims Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed to assess liver disease progression according to the non-invasi
Externí odkaz:
https://doaj.org/article/20684bd7459a42a999c55f58c9c6cca6
Autor:
Iulia Minciuna, Caroline den Hoed, Adriaan J. van der Meer, Milan J. Sonneveld, Dave Sprengers, Robert J. de Knegt, Jeroen de Jonge, Raoel Maan, Wojciech G. Polak, Sarwa Darwish Murad
Publikováno v:
Transplant International, Vol 36 (2023)
Early detection of liver transplantation (LT) vascular complications enables timely management. Our aim was to assess if routine Doppler ultrasound (rDUS) improves the detection of hepatic artery thrombosis (HAT), portal vein thrombosis (PVT) and hep
Externí odkaz:
https://doaj.org/article/24c8d60a6593482db720ed2e260cbc22
Autor:
Sylvia M. Brakenhoff, Robert J. de Knegt, Margo J.H. van Campenhout, Annemiek A. van der Eijk, Willem P. Brouwer, Florian van Bömmel, André Boonstra, Bettina E. Hansen, Thomas Berg, Harry L.A. Janssen, Robert A. de Man, Milan J. Sonneveld
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 56, Iss 1, Pp 31-39 (2023)
Background/Purpose(s): Since ALT flares after therapy withdrawal are associated with adverse outcomes, risk stratification is of major importance. We aimed to study whether off-treatment flares are related with virological outcomes, and if serum leve
Externí odkaz:
https://doaj.org/article/f650211b839742969e63754dc2c70f24
Autor:
Manuel Castro Cabezas, Bas M van Dalen, Diederick E Grobbee, Ellen M van der Zwan, Jan A Apers, Robert J de Knegt, Danny A Kanhai, Willy B Theel, Bianca M Boxma-de Klerk, Femme Dirksmeier-Harinck, Elisabeth FC van Rossum, Bojou Neecke, Thomas Hankemeier, Janneke Wiebolt
Publikováno v:
BMJ Open, Vol 13, Iss 7 (2023)
Introduction The prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 25% in the general population to 90% in patients with obesity scheduled for bariatric surgery. NAFLD can progress towards non-alcoholic steatohepatitis (NASH) associ
Externí odkaz:
https://doaj.org/article/8a6f0ce46a8243819540b9c7a23b37cc
Autor:
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Guillem Pera, Céline Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Ginès, for the LiverScreen Consortium investigators
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted tre
Externí odkaz:
https://doaj.org/article/190002eb7b394df3af13c8d603576ee0
Autor:
Wen-Yue Liu, Xiaofang Zhang, Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Rafael S. Rios, Kenneth I. Zheng, Hong-Lei Ma, Xiao-Dong Wang, Qiuwei Pan, Robert J. de Knegt, Luca Valenti, Mohsen Ghanbari, Ming-Hua Zheng
Publikováno v:
Clinical and Molecular Hepatology, Vol 28, Iss 2, Pp 183-195 (2022)
Background/Aims Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL) gene in human, has bee
Externí odkaz:
https://doaj.org/article/304fd94ed6344d8da667b59bde02db3d