Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Robert J Benschop"'
Autor:
Joel Crespo, Yi Ting Koh, Ningjie Hu, Paul A Moore, Ezio Bonvini, Andrew L Glasebrook, Andrea P Martin, Robert J Benschop
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245917 (2021)
Pre-clinical murine models are critical for translating drug candidates from the bench to the bedside. There is interest in better understanding how anti-human CD3 therapy works based on recent longitudinal studies of short-term administration. Altho
Externí odkaz:
https://doaj.org/article/284cea3843ea48808b3b32fa3cdf258b
Autor:
Daniel J Wallace, Michelle A Petri, Thomas Dörner, Stephanie de Bono, Robert J Benschop, Ernst R Dow, Damiano Fantini, Richard E Higgs, Guilherme Rocha, Brenda Crowe, Nicole L Byers, Maria E Silk, Robert W Hoffman
Publikováno v:
Lupus Science and Medicine, Vol 7, Iss 1 (2020)
Objective To characterise the molecular pathways impacted by the pharmacologic effects of the Janus kinase (JAK) 1 and JAK2 inhibitor baricitinib in SLE.Methods In a phase II, 24-week, randomised, placebo-controlled, double-blind study (JAHH), RNA wa
Externí odkaz:
https://doaj.org/article/e5cc766cafc64ce9bf61c760b2589fcd
Autor:
Richard G Conway, Eyassu Chernet, David C De Rosa, Robert J Benschop, Anne B Need, Emily C Collins, James S Bean, J Michael Kalbfleisch, Mark D Rekhter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50349 (2012)
(18)F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive glucose analog in atherosclerotic plaques. FDG-PET is challenging in mouse models due to l
Externí odkaz:
https://doaj.org/article/f41871f555ec4207b4e3c75e279b22fc
Autor:
Angela J. Okragly, Aya Ryuzoji, Isabella Wulur, Montanea Daniels, Robert D. Van Horn, Chetan N. Patel, Robert J. Benschop
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 7, Pp 1535-1547 (2023)
Abstract Introduction IL-13 is the primary upregulated cytokine in atopic dermatitis (AD) skin and is the pathogenic mediator driving AD pathophysiology. Lebrikizumab, tralokinumab and cendakimab are therapeutic monoclonal antibodies (mAb) that targe
Externí odkaz:
https://doaj.org/article/dbd152b9d5754b53906c6ae3157c3648
Autor:
Anna-Mari Schroderus, Josh Poorbaugh, Samantha McElyea, Stephanie Beasley, Lin Zhang, Kirsti Näntö-Salonen, Reeta Rintamäki, Jussi Pihlajamäki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Robert J. Benschop, Tuure Kinnunen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression
Externí odkaz:
https://doaj.org/article/b555d9125ad4498f8dc8f29fb83c028e
Autor:
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 4, Pp 288-299 (2022)
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. We i
Externí odkaz:
https://doaj.org/article/7bf9364f9ed048b68c6e9061d4e747da
Autor:
Gregory Huhn, Josh Poorbaugh, Lin Zhang, Stephanie Beasley, Ajay Nirula, Jennifer Brothers, Sharon Welbel, James Wilson, Sheena Gillani, Kathleen M. Weber, Ralph Morack, Kody Keckler, Robert J. Benschop
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Background The humoral response to SARS-CoV-2 can provide immunity and prevent reinfection. However, less is known about how the diversity, magnitude, and length of the antibody response after a primary infection is associated with symptoms, post-inf
Externí odkaz:
https://doaj.org/article/a5cae4cf70494a3f8c5b1cc1795dd4a5
Autor:
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology. 4:288-299
Objective: \ud Fibroblast-like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd7ebefc1bd0d241c985fc753872791
https://doi.org/10.1002/acr2.11384
https://doi.org/10.1002/acr2.11384
Autor:
Charles Benson, Emmanuel Chigutsa, Amit Saxena, Paul Klekotka, Peter Chen, Gourab Datta, Ariel Kay, Josh Poorbaugh, Mark J. Mulligan, William A. Fischer, Ying Grace Li, Karen L. Price, Patricia Brown-Augsburger, Ajay Nirula, Robert J. Benschop, Nadine Rouphael, Jenny Y. Chien, Jeffrey Fill, Michael Dougan
Publikováno v:
Clinical Pharmacology and Therapeutics
Therapeutics for patients hospitalized with coronavirus disease 2019 (COVID-19) are urgently needed during the pandemic. Bamlanivimab is a potent neutralizing monoclonal antibody that blocks severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fc98bbcb8ce46dfce4862bd9a03be5
http://europepmc.org/articles/PMC8653186
http://europepmc.org/articles/PMC8653186
Autor:
Aaron M Gruver, Salisha Hill, Daniel C. Liebler, Jochen Schmitz, Juraj Bodo, Keith Lai, Robert J. Benschop, Bradley L. Ackermann, David C Gemperline, Ryan D. Morrison, Eric D. Hsi, Matt D Westfall
Publikováno v:
Journal of Clinical Pathology. 75:636-642
Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f40e2adf179798c79c03a186d40329c
https://doi.org/10.1136/jclinpath-2021-207718
https://doi.org/10.1136/jclinpath-2021-207718