The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling.

Autor: Yi-Shan Chen, Robert J Bastidas, Hector A Saka, Victoria K Carpenter, Kristian L Richards, Gregory V Plano, Raphael H Valdivia

Publikováno v: PLoS Pathogens, Vol 10, Iss 2, p e1003954 (2014)

Chlamydia trachomatis, the causative agent of trachoma and sexually transmitted infections, employs a type III secretion (T3S) system to deliver effector proteins into host epithelial cells to establish a replicative vacuole. Aside from the phosphopr

Externí odkaz: https://doaj.org/article/b2a098f21faf420c86ab2cf2ce755593

The acetylase activity of Cdu1 protects Chlamydia effectors from degradation to regulate bacterial exit from infected cells

Autor: Robert J. Bastidas, Mateusz Kędzior, Lee Dolat, Barbara S. Sixt, Jonathan N. Pruneda, Raphael H. Valdivia

Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Bacterial pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0636a3ffe7ff80f6ccc2e4cc48006bf0
https://doi.org/10.7554/elife.87386

Ptr/CTL0175 Is Required for the Efficient Recovery of Chlamydia trachomatis From Stress Induced by Gamma-Interferon

Autor: Raphael H. Valdivia, María T. Damiani, Agustin Leonardo Lujan, Robert J. Bastidas, Hector Alex Saka, Maria Emilia Panzetta

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)

Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen in humans and a frequent cause of asymptomatic, persistent infections leading to serious complications, particularly in young women. Chlamydia displays a unique obligate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ab5e2d82199f5a27158e99b253b09f
https://doi.org/10.3389/fmicb.2019.00756

The Expanding Molecular Genetics Tool Kit in Chlamydia

Autor: Raphael H. Valdivia, Robert J. Bastidas

Publikováno v: Journal of Bacteriology. 200

As obligate intracellular bacteria, Chlamydia spp. have evolved numerous, likely intricate, mechanisms to create and maintain a privileged intracellular niche. Recent progress in elucidating and characterizing these processes has been bolstered by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92a0fe58a63a51d58533e6e31afd26
https://doi.org/10.1128/jb.00590-18

N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF

Autor: Åsa Gylfe, Olli Salin, C. David Andersson, Raphael H. Valdivia, Patrik Engström, Sergio A. Mojica, Robert J. Bastidas, Mikael Elofsson, Mattias Hedenström, Carlos Núñez-Otero, Naresh Sunduru

Publikováno v: Antimicrobial Agents and Chemotherapy. 61

The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated that Chlamydia is capable of FASII and this pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83af1acbae6e30b0eaaa87f249ec1d
https://doi.org/10.1128/aac.00716-17