Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Robert J, Wordinger"'
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. Bone morphogenetic proteins (BMPs) regulate TGF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d01682969f0e11f15b24b2e50ed40a7
http://europepmc.org/articles/PMC5295782
http://europepmc.org/articles/PMC5295782
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 30:121-127
Glucocorticoid (GC)-induced ocular hypertension (OHT) is a serious side effect of GC therapy in susceptible individuals. This OHT is due to increased aqueous humor (AH) outflow resistance in the trabecular meshwork (TM) caused by GC-mediated changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b09235798a0c012d9fe54a8e3568750
https://doi.org/10.1089/jop.2013.0239
https://doi.org/10.1089/jop.2013.0239
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 30:154-162
Primary open-angle glaucoma (POAG) is the second leading cause of blindness worldwide. Elevated intraocular pressure (IOP) is a primary risk factor associated with POAG. Increased aqueous humor (AH) outflow resistance through the trabecular meshwork
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346c0d46b7d1d9c4581f69f49a20c441
https://doi.org/10.1089/jop.2013.0220
https://doi.org/10.1089/jop.2013.0220
Publikováno v:
Experimental Eye Research. 116:419-423
TGFβ2 induces extracellular matrix (ECM) remodeling and alters the cytoskeleton by both the canonical Smad and non-canonical signaling pathways. TGFβ2 regulates the expression of ECM proteins in trabecular meshwork (TM) cells, increases intraocular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592f9564ea0a077f8aea030e0e313361
https://doi.org/10.1016/j.exer.2013.10.017
https://doi.org/10.1016/j.exer.2013.10.017
Autor:
Robert J. Wordinger, Yang Liu, Iok-Hou Pang, Sean M. Silverman, Byung Jin Kim, Abbot F. Clark
Publikováno v:
Molecular Neurodegeneration
Background The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat retinal ganglion cell (RGC) death and in mouse retina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e709372ff46b68b251d156bd88595f
https://doi.org/10.1186/s13024-016-0093-4
https://doi.org/10.1186/s13024-016-0093-4
Autor:
Simon W. M. John, Garreth R. Howell, Sean M. Silverman, Robert J. Wordinger, Byung Jin Kim, Joselyn Miller, Abbot F. Clark
Publikováno v:
Molecular Neurodegeneration
Background C1q represents the initiating protein of the classical complement cascade, however recent findings indicate pathway independent roles such as developmental pruning of retinal ganglion cell (RGC) axons. Furthermore, chronic neuroinflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03735c7ec7e71f03fb10437e5802c5b1
https://doi.org/10.1186/s13024-016-0089-0
https://doi.org/10.1186/s13024-016-0089-0
Autor:
Abbot F. Clark, Tomi Luan, Tasneem Putliwala, Iok-Hou Pang, Robert J. Wordinger, Colleen M McDowell, J. Cameron Millar, Simon W. M. John, Zhang Zhang
Publikováno v:
Experimental Eye Research. 100:65-72
Elevated intraocular pressure (IOP) is a causative risk factor for the development and progression of glaucoma. Glaucomatous mutations in myocilin (MYOC) damage the trabecular meshwork and elevate IOP in humans and in mice. Animal models of glaucoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cab8852edaca60b881e955f97f48ba7
https://doi.org/10.1016/j.exer.2012.04.016
https://doi.org/10.1016/j.exer.2012.04.016
Publikováno v:
Glia. 57:755-766
The characteristic cupping of the optic nerve head (ONH) in glaucoma is associated with elevated TGF-beta2 and increased synthesis and deposition of extracellular matrix (ECM) proteins. In addition to TGF-beta2, the human ONH also expresses bone morp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea12d1c24eb50010062db7db5f20529
https://doi.org/10.1002/glia.20803
https://doi.org/10.1002/glia.20803
Publikováno v:
Clinical Anatomy. 17:337-344
The need to increase the efficiency of dissection in the gross anatomy laboratory has been the driving force behind the technologic changes we have recently implemented. With the introduction of an integrated systems-based medical curriculum and a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8c743b038b1475ff58a1b92d1b1849
https://doi.org/10.1002/ca.10245
https://doi.org/10.1002/ca.10245
Autor:
Abbot F. Clark, Robert J. Wordinger
Publikováno v:
Journal of glaucoma. 23(8 Suppl 1)
The mechanical properties of the extracellular matrix (ECM) play an important role in maintaining cellular function and overall tissue homeostasis. Emerging evidence suggests that biomechanical modifications of the ECM may be initiators and/or driver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d82fdcd13813960515d4b1f3d2fe55f
https://pubmed.ncbi.nlm.nih.gov/25275908
https://pubmed.ncbi.nlm.nih.gov/25275908