Zobrazeno 1 - 10
of 1 296
pro vyhledávání: '"Robert J, Linhardt"'
Autor:
Esam S. Al-Malki, Omar A. Ahmed-Farid, Mahmoud M.A. Moustafa, Shimaa A. Haredy, Omnia A. Badr, Nesreen Nabil Omar, Robert J. Linhardt, Mohamad Warda
Publikováno v:
Scientific African, Vol 26, Iss , Pp e02347- (2024)
Externí odkaz:
https://doaj.org/article/3abc530e3bdd41129d85f2bf262895e8
Autor:
Esam S. Al-Malki, Omar A. Ahmed-Farid, Mahmoud M.A. Moustafa, Shimaa A. Haredy, Omnia A. Badr, Nesreen Nabil Omar, Robert J. Linhardt, Mohamad Warda
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02177- (2024)
Obesity stands as a pervasive and significant global health issue, with a lack of definitive and curative therapeutic solutions currently available. Here we studied the synergetic ameliorating effect of coupled administration of GABA agonist; baclofe
Externí odkaz:
https://doaj.org/article/1411bb3195514a54835824df4b588c47
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1776 (2024)
Hepatitis B virus (HBV) infection remains a major health threat with limited treatment options. One of various new antiviral strategies is based on a fusion of Staphylococcus aureus nuclease (SN) with the capsid-forming HBV core protein (HBc), termed
Externí odkaz:
https://doaj.org/article/8062dc1761924874a3646ad76707d6e8
Autor:
Jiyuan Yang, Yuefan Song, Ke Xia, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
Publikováno v:
Marine Drugs, Vol 22, Iss 5, p 232 (2024)
Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate,
Externí odkaz:
https://doaj.org/article/67ebfea3f0544ab5bdfa9a3a29c24e5e
Autor:
Paul S. Kwon, Shirley Xu, Hanseul Oh, Seok-Joon Kwon, Andre L. Rodrigues, Maisha Feroz, Keith Fraser, Peng He, Fuming Zhang, Jung Joo Hong, Robert J. Linhardt, Jonathan S. Dordick
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on SARS-CoV-2 RBDs with preferential binding for Omicron RBD and inhibition of infection by the Omicron variant in vitro.
Externí odkaz:
https://doaj.org/article/f9c4ce0ff01c4a649d774200f246e2fd
Autor:
Jiyuan Yang, Yuefan Song, Weihua Jin, Ke Xia, Grace C. Burnett, Wanjin Qiao, John T. Bates, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
Publikováno v:
Viruses, Vol 16, Iss 2, p 237 (2024)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively char
Externí odkaz:
https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77
Autor:
Jiahui Lu, Anqiang Zhang, Fuming Zhang, Robert J. Linhardt, Zhihui Zhu, Yanzi Yang, Tinghuang Zhang, Zhibin Lin, Su Zhang, Huajun Zhao, Peilong Sun
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114947- (2023)
Ganoderenic acid D (GAD), extracted from the Chinese herb Ganoderma lucidum, was loaded onto a graphene oxide-polyethylene glycol-anti-epidermal growth factor receptor (GO-PEG-EGFR) carrier to develop a targeting antitumor nanocomposite (GO-PEG@GAD).
Externí odkaz:
https://doaj.org/article/c6f80d28c99d4847a3fbe85563a8500f
Autor:
Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Pham, Jian Liu, Fuming Zhang, Andrew Almond, Robert J. Linhardt, Paul L. DeAngelis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccha
Externí odkaz:
https://doaj.org/article/ef461400591343048c9e59e0041eaaf1
Autor:
Deling Shi, Peng He, Yuefan Song, Robert J. Linhardt, Jonathan S. Dordick, Lianli Chi, Fuming Zhang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: The unexpected surge of respiratory syncytial virus (RSV) cases following pandemic phase of COVID-19 has drawn much public attention. Drawing on the latest antiviral research, revisiting this heightened annual outbreak of respiratory di
Externí odkaz:
https://doaj.org/article/5c07cb5c2fdd485d8d24e10316bafc3d
Autor:
Lauren A. Gandy, Ashley J. Canning, Huan Lou, Ke Xia, Peng He, Guowei Su, Tina Cairns, Jian Liu, Fuming Zhang, Robert J. Linhardt, Gary Cohen, Chunyu Wang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Literature has well-established the importance of 3-O-sulfation of neuronal cell surface glycan heparan sulfate (HS) to its interaction with herpes simplex virus type 1 glycoprotein D (gD). Previous investigations of gD to its viral receptors HVEM an
Externí odkaz:
https://doaj.org/article/de28aa88bd2e478586a416aa5437de78