Zobrazeno 1 - 10
of 713
pro vyhledávání: '"Robert J, Lefkowitz"'
Autor:
Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, Milton Packer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/1516c52dd4af4fd98dff325b5997c3e9
Autor:
Seungkirl Ahn, Harm Maarsingh, Julia K.L. Walker, Samuel Liu, Akhil Hegde, Hyeje C. Sumajit, Alem W. Kahsai, Robert J. Lefkowitz
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Asthma is a chronic inflammatory disease associated with episodic airway narrowing. Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote — with limited efficacy — bronchodilation in asthma. All β2-agonists are canonical orthos
Externí odkaz:
https://doaj.org/article/7baee4fa0bf4499f85b0ab428028efe2
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283477 (2023)
G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins. [Sarcosine1Ile4Ile8]-angiotensin II (SII), an analog of the endogenous ligand angiotensin
Externí odkaz:
https://doaj.org/article/1626b8ed14aa479c84ac966c7bfe159b
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
Autor:
Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, Robert J. Lefkowitz
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Background β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β2AR stimulation on skeletal muscle is anabolic gr
Externí odkaz:
https://doaj.org/article/23829cd6bf1d4dbe84a5e0112c5c0274
Autor:
Laura J. Stoppel, Benjamin D. Auerbach, Rebecca K. Senter, Anthony R. Preza, Robert J. Lefkowitz, Mark F. Bear
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2807-2814 (2017)
Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability. Neural activity directs loc
Externí odkaz:
https://doaj.org/article/78ddbfd20cf341f5b1e3f6be919e30eb
Autor:
Paula K. Rambarat, Biswaranjan Pani, Robert J. Lefkowitz, Shashank Vege, Seungkirl Ahn, Dean P. Staus, Bruno N. Valan, Tommaso Costa, Alem W. Kahsai, Andrew Liu
Publikováno v:
Molecular Pharmacology. 100:513-525
Among β-blockers that are clinically prescribed for heart failure, carvedilol is a first-choice agent with unique pharmacological properties. Carvedilol is distinct from other β-blockers in its ability to elicit β-arrestin-biased agonism, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7ae1a5d7fc7bdd6a4374179ff46d40
https://doi.org/10.1124/molpharm.121.000363
https://doi.org/10.1124/molpharm.121.000363
Autor:
Seungkirl Ahn, Howard A. Rockman, Haoran Jiang, Ilhan Gokhan, Jialu Wang, Xinyu Xiong, Biswaranjan Pani, Robert J. Lefkowitz, Alem W. Kahsai
Publikováno v:
Mol Pharmacol
β(1) adrenergic receptors (β(1)ARs) are central regulators of cardiac function and a drug target for cardiac disease. As a member of the G protein–coupled receptor family, β(1)ARs activate cellular signaling by primarily coupling to Gs proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899cdde539ac9323e772614fd83c35b4
https://doi.org/10.1124/molpharm.121.000359
https://doi.org/10.1124/molpharm.121.000359
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c6b8ad902d81ecd2b4b8a6869130361
https://doi.org/10.1096/fasebj.2022.36.s1.r2797
https://doi.org/10.1096/fasebj.2022.36.s1.r2797
Autor:
Wayne L. Hubbell, Andrew C. Kruse, Robert J. Lefkowitz, Conor McMahon, Howard A. Rockman, Matthias Elgeti, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Dean P. Staus
Publikováno v:
Proc Natl Acad Sci U S A
There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b35f906b7b9631e5554ad558505ea4
https://doi.org/10.1073/pnas.2009029117
https://doi.org/10.1073/pnas.2009029117
Autor:
Robert J. Lefkowitz, Alissa L. W. Kleinhenz, Meredith A. Skiba, Andrew C. Kruse, Carl-Mikael Suomivuori, Conor McMahon, Dean P. Staus, Ron O. Dror, Naomi R. Latorraca, Laura M. Wingler
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6a468f15f31a04e563eca4ab612dd6
https://doi.org/10.1126/science.aay9813
https://doi.org/10.1126/science.aay9813