Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Robert J, Klein"'
Autor:
Srilakshmi Srinivasan, Thomas Kryza, Nathalie Bock, Brian W. C. Tse, Kamil A. Sokolowski, Panchadsaram Janaththani, Achala Fernando, Leire Moya, Carson Stephens, Ying Dong, Joan Röhl, Saeid Alinezhad, Ian Vela, Joanna L. Perry-Keene, Katie Buzacott, Robert Nica, The IMPACT Study, Manuela Gago-Dominguez, The PROFILE Study Steering Committee, Johanna Schleutker, Christiane Maier, Kenneth Muir, Catherine M. Tangen, Henrik Gronberg, Nora Pashayan, Demetrius Albanes, Alicja Wolk, Janet L. Stanford, Sonja I. Berndt, Lorelei A. Mucci, Stella Koutros, Olivier Cussenot, Karina Dalsgaard Sorensen, Eli Marie Grindedal, Ruth C. Travis, Christopher A. Haiman, Robert J. MacInnis, Ana Vega, Fredrik Wiklund, David E. Neal, Manolis Kogevinas, Kathryn L. Penney, Børge G. Nordestgaard, Hermann Brenner, Esther M. John, Marija Gamulin, Frank Claessens, Olle Melander, Anders Dahlin, Pär Stattin, Göran Hallmans, Christel Häggström, Robert Johansson, Elin Thysell, Ann-Charlotte Rönn, Weiqiang Li, Nigel Brown, Goce Dimeski, Benjamin Shepherd, Tokhir Dadaev, Mark N. Brook, Amanda B. Spurdle, Ulf-Håkan Stenman, Hannu Koistinen, Zsofia Kote-Jarai, Robert J. Klein, Hans Lilja, Rupert C. Ecker, Rosalind Eeles, The Practical Consortium, The Australian Prostate Cancer BioResource, Judith Clements, Jyotsna Batra
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced
Externí odkaz:
https://doaj.org/article/8eafcf751cfb463fb1624d18ac08892c
Autor:
Kevin A. Mazurek, Linhao Li, Robert J. Klein, Shengliang Rong, Aidan F. Mullan, David T. Jones, Erik K. St. Louis, Gregory A. Worrell, Christina Y. Chen
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background The worldwide number of adults aged 60 years and older is expected to double from 1 billion in 2019 to 2.1 billion by 2050. As the population lives longer, the rising incidence of chronic diseases, cognitive disorders, and behavio
Externí odkaz:
https://doaj.org/article/f465bba4d8684e43aa836c648260b565
Autor:
Laurel A. Habel, Stacey E. Alexeeff, Ninah Achacoso, Vignesh A. Arasu, Aimilia Gastounioti, Lawrence Gerstley, Robert J. Klein, Rhea Y. Liang, Jafi A. Lipson, Walter Mankowski, Laurie R. Margolies, Joseph H. Rothstein, Daniel L. Rubin, Li Shen, Adriana Sistig, Xiaoyu Song, Marvella A. Villaseñor, Mark Westley, Alice S. Whittemore, Martin J. Yaffe, Pei Wang, Despina Kontos, Weiva Sieh
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-9 (2023)
Abstract Background Breast density is strongly associated with breast cancer risk. Fully automated quantitative density assessment methods have recently been developed that could facilitate large-scale studies, although data on associations with long
Externí odkaz:
https://doaj.org/article/c80b8409fd6744bfba5b869ab41e08e7
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Recent studies show that rare, deleterious variants (RDVs) in certain genes are critical determinants of heritable cancer risk. To more comprehensively understand RDVs, we performed the largest-to-date germline variant calling analysis in a
Externí odkaz:
https://doaj.org/article/47e06faee0814247a1d715838f2deb86
Autor:
Xiaoyu Song, Jiayi Ji, Joseph H. Rothstein, Stacey E. Alexeeff, Lori C. Sakoda, Adriana Sistig, Ninah Achacoso, Eric Jorgenson, Alice S. Whittemore, Robert J. Klein, Laurel A. Habel, Pei Wang, Weiva Sieh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genoty
Externí odkaz:
https://doaj.org/article/ceaf0e837c184398af50f0d44046921d
Autor:
Robert J. Klein, Emily Vertosick, Dan Sjoberg, David Ulmert, Ann-Charlotte Rönn, Christel Häggström, Elin Thysell, Göran Hallmans, Anders Dahlin, Pär Stattin, Olle Melander, Andrew Vickers, Hans Lilja
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified screening program to avoid excessive overdiagnosis. Herein, PRS
Externí odkaz:
https://doaj.org/article/5f0a0b867c3d40ad97478098664fd2bd
Autor:
Weiva Sieh, Joseph H. Rothstein, Robert J. Klein, Stacey E. Alexeeff, Lori C. Sakoda, Eric Jorgenson, Russell B. McBride, Rebecca E. Graff, Valerie McGuire, Ninah Achacoso, Luana Acton, Rhea Y. Liang, Jafi A. Lipson, Daniel L. Rubin, Martin J. Yaffe, Douglas F. Easton, Catherine Schaefer, Neil Risch, Alice S. Whittemore, Laurel A. Habel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mammographic density represents one the strongest predictors of breast cancer risk. Here the authors perform genome-wide association study meta-analysis of women screened with full-field digital mammography and identify 31 previously unreported loci
Externí odkaz:
https://doaj.org/article/455a1267540b4504a0c8a2bad60954fb
Autor:
Jing Zhang, Donghoon Lee, Vineet Dhiman, Peng Jiang, Jie Xu, Patrick McGillivray, Hongbo Yang, Jason Liu, William Meyerson, Declan Clarke, Mengting Gu, Shantao Li, Shaoke Lou, Jinrui Xu, Lucas Lochovsky, Matthew Ung, Lijia Ma, Shan Yu, Qin Cao, Arif Harmanci, Koon-Kiu Yan, Anurag Sethi, Gamze Gürsoy, Michael Rutenberg Schoenberg, Joel Rozowsky, Jonathan Warrell, Prashant Emani, Yucheng T. Yang, Timur Galeev, Xiangmeng Kong, Shuang Liu, Xiaotong Li, Jayanth Krishnan, Yanlin Feng, Juan Carlos Rivera-Mulia, Jessica Adrian, James R Broach, Michael Bolt, Jennifer Moran, Dominic Fitzgerald, Vishnu Dileep, Tingting Liu, Shenglin Mei, Takayo Sasaki, Claudia Trevilla-Garcia, Su Wang, Yanli Wang, Chongzhi Zang, Daifeng Wang, Robert J. Klein, Michael Snyder, David M. Gilbert, Kevin Yip, Chao Cheng, Feng Yue, X. Shirley Liu, Kevin P. White, Mark Gerstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.
Externí odkaz:
https://doaj.org/article/d3ef1766b33842a5aa6bd3194efeba4e
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Previous research has demonstrated that adults with comorbid depressive and anxiety disorders are significantly more likely to show pathological use of drugs or alcohol. Few studies, however, have examined associations of this type in children. A bet
Externí odkaz:
https://doaj.org/article/b741c39384664409a7a757b598ccd157
Publikováno v:
Internet Interventions, Vol 25, Iss , Pp 100424- (2021)
Introduction: Online social networking data (SN) is a contextually and temporally rich data stream that has shown promise in the prediction of suicidal thought and behavior. Despite the clear advantages of this digital medium, predictive modeling of
Externí odkaz:
https://doaj.org/article/7a305050cefe4bfba04c7157f749cf65